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Superior Biochemical Recurrence and Long-term Quality-of-life Outcomes Are Achievable with Robotic Radical Prostatectomy After a Long Learning Curve-Updated Analysis of a Prospective Single-surgeon Cohort of 2206 Consecutive Cases.
Eur Urol. 2018 05; 73(5):664-671.EU

Abstract

BACKGROUND

Our earlier analysis suggested that robot-assisted radical prostatectomy (RARP) achieved superiority over open radical prostatectomy (ORP) in terms of positive surgical margin (PSM) rates and functional outcomes.

OBJECTIVE

With larger sample size and longer follow-up, the objective of this study update is to assess whether our previous findings are upheld and whether the improved PSM rates for RARP after an initial learning curve compared with ORP-as observed in our earlier analysis-ultimately resulted in improved biochemical control.

DESIGN, SETTING, AND PARTICIPANTS

Prospective observational study comparing two surgical techniques; 2271 consecutive men underwent RARP (1520) or ORP (751) at a single centre from 2006 to 2016.

OUTCOME MEASUREMENTS AND STATISTICAL ANALYSIS

Demographic and clinicopathological data were prospectively collected. The EPIC-QOL questionnaire was administered at baseline and 1.5, 3, 6, 12, and 24 mo. Multivariate linear regression modelled the difference in quality of life (QOL) domains against case number; logistic and Cox regression modelled the differences in PSM and biochemical recurrence (BCR) hazard ratios (HR), respectively.

RESULTS AND LIMITATIONS

A total of 2206 men were included in BCR/PSM analysis and 1045 consented for QOL analysis. Superior pT2 surgical margins, early and late sexual outcomes, and early urinary outcomes were upheld and became more robust (narrowing of 95% confidence intervals [CIs]). The risk of BCR was initially higher for RARP, improved after 191 RARPs, and was 35% lower (hazard ratio [HR] 0.65, 95% CI 0.47-0.90) at final RARP, plateauing after 226 RARPs. Improved late (12-24 mo) urinary bother scores (adjusted mean difference [AMD]=4.7, 95% CI 1.3-8.0) and irritative-obstructive scores (AMD=3.8, 95% CI 0.9-5.6) at final RARP were demonstrated. Limitations include observational single surgeon data, possible residual confounding, and short follow-up.

CONCLUSIONS

The results from this updated analysis demonstrate that RARP can be beneficial for patients of high-volume surgeons, although more randomised studies and studies with survival outcomes are needed.

PATIENT SUMMARY

Robot-assisted radical prostatectomy was able to improve functional and oncological outcomes in this single surgeon's learning curve.

Authors+Show Affiliations

St Vincent's Prostate Cancer Centre, Darlinghurst, NSW, Australia; Garvan Institute of Medical Research & The Kinghorn Cancer Centre, Darlinghurst, NSW, Australia; The University of New South Wales, Kensington, NSW, Australia. Electronic address: drjethompson@gmail.com.Cancer Council NSW, Woolloomooloo, NSW, Australia.Garvan Institute of Medical Research & The Kinghorn Cancer Centre, Darlinghurst, NSW, Australia.St Vincent's Prostate Cancer Centre, Darlinghurst, NSW, Australia; Garvan Institute of Medical Research & The Kinghorn Cancer Centre, Darlinghurst, NSW, Australia.Garvan Institute of Medical Research & The Kinghorn Cancer Centre, Darlinghurst, NSW, Australia.St Vincent's Prostate Cancer Centre, Darlinghurst, NSW, Australia.St Vincent's Prostate Cancer Centre, Darlinghurst, NSW, Australia; Garvan Institute of Medical Research & The Kinghorn Cancer Centre, Darlinghurst, NSW, Australia; Academic Medical Center, Amsterdam, The Netherlands.St Vincent's Prostate Cancer Centre, Darlinghurst, NSW, Australia; Garvan Institute of Medical Research & The Kinghorn Cancer Centre, Darlinghurst, NSW, Australia; The University of New South Wales, Kensington, NSW, Australia.

Pub Type(s)

Comparative Study
Journal Article
Observational Study
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

29273404

Citation

Thompson, James E., et al. "Superior Biochemical Recurrence and Long-term Quality-of-life Outcomes Are Achievable With Robotic Radical Prostatectomy After a Long Learning Curve-Updated Analysis of a Prospective Single-surgeon Cohort of 2206 Consecutive Cases." European Urology, vol. 73, no. 5, 2018, pp. 664-671.
Thompson JE, Egger S, Böhm M, et al. Superior Biochemical Recurrence and Long-term Quality-of-life Outcomes Are Achievable with Robotic Radical Prostatectomy After a Long Learning Curve-Updated Analysis of a Prospective Single-surgeon Cohort of 2206 Consecutive Cases. Eur Urol. 2018;73(5):664-671.
Thompson, J. E., Egger, S., Böhm, M., Siriwardana, A. R., Haynes, A. M., Matthews, J., Scheltema, M. J., & Stricker, P. D. (2018). Superior Biochemical Recurrence and Long-term Quality-of-life Outcomes Are Achievable with Robotic Radical Prostatectomy After a Long Learning Curve-Updated Analysis of a Prospective Single-surgeon Cohort of 2206 Consecutive Cases. European Urology, 73(5), 664-671. https://doi.org/10.1016/j.eururo.2017.11.035
Thompson JE, et al. Superior Biochemical Recurrence and Long-term Quality-of-life Outcomes Are Achievable With Robotic Radical Prostatectomy After a Long Learning Curve-Updated Analysis of a Prospective Single-surgeon Cohort of 2206 Consecutive Cases. Eur Urol. 2018;73(5):664-671. PubMed PMID: 29273404.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Superior Biochemical Recurrence and Long-term Quality-of-life Outcomes Are Achievable with Robotic Radical Prostatectomy After a Long Learning Curve-Updated Analysis of a Prospective Single-surgeon Cohort of 2206 Consecutive Cases. AU - Thompson,James E, AU - Egger,Sam, AU - Böhm,Maret, AU - Siriwardana,Amila R, AU - Haynes,Anne-Maree, AU - Matthews,Jayne, AU - Scheltema,Matthijs J, AU - Stricker,Phillip D, Y1 - 2017/12/19/ PY - 2017/08/05/received PY - 2017/11/28/accepted PY - 2017/12/24/pubmed PY - 2019/2/15/medline PY - 2017/12/24/entrez KW - Biochemical recurrence KW - Comparative study KW - Learning curve KW - Oncological outcomes KW - Positive surgical margin KW - Prospective KW - Quality of life KW - Radical prostatectomy KW - Retropubic KW - Robotic SP - 664 EP - 671 JF - European urology JO - Eur. Urol. VL - 73 IS - 5 N2 - BACKGROUND: Our earlier analysis suggested that robot-assisted radical prostatectomy (RARP) achieved superiority over open radical prostatectomy (ORP) in terms of positive surgical margin (PSM) rates and functional outcomes. OBJECTIVE: With larger sample size and longer follow-up, the objective of this study update is to assess whether our previous findings are upheld and whether the improved PSM rates for RARP after an initial learning curve compared with ORP-as observed in our earlier analysis-ultimately resulted in improved biochemical control. DESIGN, SETTING, AND PARTICIPANTS: Prospective observational study comparing two surgical techniques; 2271 consecutive men underwent RARP (1520) or ORP (751) at a single centre from 2006 to 2016. OUTCOME MEASUREMENTS AND STATISTICAL ANALYSIS: Demographic and clinicopathological data were prospectively collected. The EPIC-QOL questionnaire was administered at baseline and 1.5, 3, 6, 12, and 24 mo. Multivariate linear regression modelled the difference in quality of life (QOL) domains against case number; logistic and Cox regression modelled the differences in PSM and biochemical recurrence (BCR) hazard ratios (HR), respectively. RESULTS AND LIMITATIONS: A total of 2206 men were included in BCR/PSM analysis and 1045 consented for QOL analysis. Superior pT2 surgical margins, early and late sexual outcomes, and early urinary outcomes were upheld and became more robust (narrowing of 95% confidence intervals [CIs]). The risk of BCR was initially higher for RARP, improved after 191 RARPs, and was 35% lower (hazard ratio [HR] 0.65, 95% CI 0.47-0.90) at final RARP, plateauing after 226 RARPs. Improved late (12-24 mo) urinary bother scores (adjusted mean difference [AMD]=4.7, 95% CI 1.3-8.0) and irritative-obstructive scores (AMD=3.8, 95% CI 0.9-5.6) at final RARP were demonstrated. Limitations include observational single surgeon data, possible residual confounding, and short follow-up. CONCLUSIONS: The results from this updated analysis demonstrate that RARP can be beneficial for patients of high-volume surgeons, although more randomised studies and studies with survival outcomes are needed. PATIENT SUMMARY: Robot-assisted radical prostatectomy was able to improve functional and oncological outcomes in this single surgeon's learning curve. SN - 1873-7560 UR - https://www.unboundmedicine.com/medline/citation/29273404/Superior_Biochemical_Recurrence_and_Long_term_Quality_of_life_Outcomes_Are_Achievable_with_Robotic_Radical_Prostatectomy_After_a_Long_Learning_Curve_Updated_Analysis_of_a_Prospective_Single_surgeon_Cohort_of_2206_Consecutive_Cases_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0302-2838(17)31027-8 DB - PRIME DP - Unbound Medicine ER -