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Red and processed meat consumption and breast cancer: UK Biobank cohort study and meta-analysis.
Eur J Cancer 2018; 90:73-82EJ

Abstract

AIM

Red and processed meat may be risk factors for breast cancer due to their iron content, administration of oestrogens to cattle or mutagens created during cooking. We studied the associations in UK Biobank and then included the results in a meta-analysis of published cohort studies.

METHODS

UK Biobank, a general population cohort study, recruited participants aged 40-69 years. Incident breast cancer was ascertained via linkage to routine hospital admission, cancer registry and death certificate data. Univariate and multivariable Cox proportional hazard models were used to explore the associations between red and processed meat consumption and breast cancer. Previously published cohort studies were identified from a systematic review using PubMed and Ovid and a meta-analysis conducted using a random effects model.

RESULTS

Over a median of 7 years follow-up, 4819 of the 262,195 women developed breast cancer. The risk was increased in the highest tertile (>9 g/day) of processed meat consumption (adjusted hazard ratio [HR] 1.21, 95% confidence interval [CI] 1.08-1.35, p = 0.001). Collation with 10 previous cohort studies provided data on 40,257 incident breast cancers in 1.65 million women. On meta-analysis, processed meat consumption was associated with overall (relative risk [RR] 1.06, 95% CI 1.01-1.11) and post-menopausal (RR 1.09, 95% CI 1.03-1.15), but not pre-menopausal (RR 0.99, 95% CI 0.88-1.10), breast cancer. In UK Biobank and the meta-analysis, red meat consumption was not associated with breast cancer (adjusted HR 0.99 95% CI 0.88-1.12 and RR 1.03, 95% CI 0.99-1.08, respectively).

CONCLUSIONS

Consumption of processed meat, but not red meat, may increase the risk of breast cancer.

Authors+Show Affiliations

Institute of Health and Wellbeing, University of Glasgow, 1 Lilybank Gardens, Glasgow, UK.Institute of Health and Wellbeing, University of Glasgow, 1 Lilybank Gardens, Glasgow, UK.Institute of Health and Wellbeing, University of Glasgow, 1 Lilybank Gardens, Glasgow, UK.Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, UK.Institute of Health and Wellbeing, University of Glasgow, 1 Lilybank Gardens, Glasgow, UK.Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, UK.Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, UK.Institute of Health and Wellbeing, University of Glasgow, 1 Lilybank Gardens, Glasgow, UK. Electronic address: jill.pell@glasgow.ac.uk.

Pub Type(s)

Journal Article
Meta-Analysis
Research Support, Non-U.S. Gov't
Systematic Review

Language

eng

PubMed ID

29274927

Citation

Anderson, Jana J., et al. "Red and Processed Meat Consumption and Breast Cancer: UK Biobank Cohort Study and Meta-analysis." European Journal of Cancer (Oxford, England : 1990), vol. 90, 2018, pp. 73-82.
Anderson JJ, Darwis NDM, Mackay DF, et al. Red and processed meat consumption and breast cancer: UK Biobank cohort study and meta-analysis. Eur J Cancer. 2018;90:73-82.
Anderson, J. J., Darwis, N. D. M., Mackay, D. F., Celis-Morales, C. A., Lyall, D. M., Sattar, N., ... Pell, J. P. (2018). Red and processed meat consumption and breast cancer: UK Biobank cohort study and meta-analysis. European Journal of Cancer (Oxford, England : 1990), 90, pp. 73-82. doi:10.1016/j.ejca.2017.11.022.
Anderson JJ, et al. Red and Processed Meat Consumption and Breast Cancer: UK Biobank Cohort Study and Meta-analysis. Eur J Cancer. 2018;90:73-82. PubMed PMID: 29274927.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Red and processed meat consumption and breast cancer: UK Biobank cohort study and meta-analysis. AU - Anderson,Jana J, AU - Darwis,Narisa D M, AU - Mackay,Daniel F, AU - Celis-Morales,Carlos A, AU - Lyall,Donald M, AU - Sattar,Naveed, AU - Gill,Jason M R, AU - Pell,Jill P, Y1 - 2017/12/21/ PY - 2017/08/22/received PY - 2017/10/25/revised PY - 2017/11/22/accepted PY - 2017/12/25/pubmed PY - 2018/9/22/medline PY - 2017/12/25/entrez KW - Breast cancer KW - Diet KW - Post-menopausal KW - Pre-menopausal KW - Processed meat KW - Red meat KW - UK Biobank SP - 73 EP - 82 JF - European journal of cancer (Oxford, England : 1990) JO - Eur. J. Cancer VL - 90 N2 - AIM: Red and processed meat may be risk factors for breast cancer due to their iron content, administration of oestrogens to cattle or mutagens created during cooking. We studied the associations in UK Biobank and then included the results in a meta-analysis of published cohort studies. METHODS: UK Biobank, a general population cohort study, recruited participants aged 40-69 years. Incident breast cancer was ascertained via linkage to routine hospital admission, cancer registry and death certificate data. Univariate and multivariable Cox proportional hazard models were used to explore the associations between red and processed meat consumption and breast cancer. Previously published cohort studies were identified from a systematic review using PubMed and Ovid and a meta-analysis conducted using a random effects model. RESULTS: Over a median of 7 years follow-up, 4819 of the 262,195 women developed breast cancer. The risk was increased in the highest tertile (>9 g/day) of processed meat consumption (adjusted hazard ratio [HR] 1.21, 95% confidence interval [CI] 1.08-1.35, p = 0.001). Collation with 10 previous cohort studies provided data on 40,257 incident breast cancers in 1.65 million women. On meta-analysis, processed meat consumption was associated with overall (relative risk [RR] 1.06, 95% CI 1.01-1.11) and post-menopausal (RR 1.09, 95% CI 1.03-1.15), but not pre-menopausal (RR 0.99, 95% CI 0.88-1.10), breast cancer. In UK Biobank and the meta-analysis, red meat consumption was not associated with breast cancer (adjusted HR 0.99 95% CI 0.88-1.12 and RR 1.03, 95% CI 0.99-1.08, respectively). CONCLUSIONS: Consumption of processed meat, but not red meat, may increase the risk of breast cancer. SN - 1879-0852 UR - https://www.unboundmedicine.com/medline/citation/29274927/Red_and_processed_meat_consumption_and_breast_cancer:_UK_Biobank_cohort_study_and_meta_analysis_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0959-8049(17)31430-2 DB - PRIME DP - Unbound Medicine ER -