Tags

Type your tag names separated by a space and hit enter

[Determination of Methcathinone in Urine by GC-MS].
Fa Yi Xue Za Zhi. 2017 Oct; 33(5):506-508.FY

Abstract

OBJECTIVES

To establish a method for the analysis of methcathinone in urine by gas chromatography-mass spectrometry (GC-MS).

METHODS

Proadifen hydrochloride (internal standard) and buffer solution (pH=9) were added into the urine samples, and methcathinone was extracted by ethyl acetate. The extract was volatilized in 50 ℃ nitrogen gas flow and the remnant was dissolved by methanol and analysed by GC-MS.

RESULTS

The methcathinone in urine showed a good linear relationship in the mass concentration range of 0.02-2.00 μg/mL. The linear equation was y=0.301 9 x+0.018 9 (r=0.999 2), and the detection limit was 0.01 μg/mL. The recoveries of methcathinone in urine was 96.4%-99.2%, with the intra-day precision of 5.8%-7.6% and the inter-day precision of 6.0%-8.1%.

CONCLUSIONS

The method is convenient and sensitive, which can be applied to the forensic identification of methcathinone in urine.

Authors+Show Affiliations

Department of Criminal Science and Technology, Hunan Police Academy, Changsha 410138, China.Department of Criminal Science and Technology, Hunan Police Academy, Changsha 410138, China.

Pub Type(s)

Journal Article

Language

chi

PubMed ID

29275556

Citation

Liu, D X., and M M. Zhao. "[Determination of Methcathinone in Urine By GC-MS]." Fa Yi Xue Za Zhi, vol. 33, no. 5, 2017, pp. 506-508.
Liu DX, Zhao MM. [Determination of Methcathinone in Urine by GC-MS]. Fa Yi Xue Za Zhi. 2017;33(5):506-508.
Liu, D. X., & Zhao, M. M. (2017). [Determination of Methcathinone in Urine by GC-MS]. Fa Yi Xue Za Zhi, 33(5), 506-508. https://doi.org/10.3969/j.issn.1004-5619.2017.05.012
Liu DX, Zhao MM. [Determination of Methcathinone in Urine By GC-MS]. Fa Yi Xue Za Zhi. 2017;33(5):506-508. PubMed PMID: 29275556.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Determination of Methcathinone in Urine by GC-MS]. AU - Liu,D X, AU - Zhao,M M, Y1 - 2017/10/25/ PY - 2017/03/15/received PY - 2017/12/25/entrez PY - 2017/12/25/pubmed PY - 2018/4/24/medline KW - forensic toxicology KW - gas chromatography-mass spectrometry KW - methcathinone KW - urine SP - 506 EP - 508 JF - Fa yi xue za zhi JO - Fa Yi Xue Za Zhi VL - 33 IS - 5 N2 - OBJECTIVES: To establish a method for the analysis of methcathinone in urine by gas chromatography-mass spectrometry (GC-MS). METHODS: Proadifen hydrochloride (internal standard) and buffer solution (pH=9) were added into the urine samples, and methcathinone was extracted by ethyl acetate. The extract was volatilized in 50 ℃ nitrogen gas flow and the remnant was dissolved by methanol and analysed by GC-MS. RESULTS: The methcathinone in urine showed a good linear relationship in the mass concentration range of 0.02-2.00 μg/mL. The linear equation was y=0.301 9 x+0.018 9 (r=0.999 2), and the detection limit was 0.01 μg/mL. The recoveries of methcathinone in urine was 96.4%-99.2%, with the intra-day precision of 5.8%-7.6% and the inter-day precision of 6.0%-8.1%. CONCLUSIONS: The method is convenient and sensitive, which can be applied to the forensic identification of methcathinone in urine. SN - 1004-5619 UR - https://www.unboundmedicine.com/medline/citation/29275556/[Determination_of_Methcathinone_in_Urine_by_GC_MS]_ L2 - https://doi.org/10.3969/j.issn.1004-5619.2017.05.012 DB - PRIME DP - Unbound Medicine ER -
Try the Free App:
Prime PubMed app for iOS iPhone iPad
Prime PubMed app for Android
Prime PubMed is provided
free to individuals by:
Unbound Medicine.