Tags

Type your tag names separated by a space and hit enter

Relationship between bisphenol A exposure and attention-deficit/ hyperactivity disorder: A case-control study for primary school children in Guangzhou, China.
Environ Pollut. 2018 Apr; 235:141-149.EP

Abstract

Bisphenol A (BPA) is an endocrine-disrupting chemical. Studies have shown that the exposure to BPA is associated with attention-deficit/hyperactivity disorder (ADHD) during adolescent development. However the direct clinical evidence is limited. To investigate the possible association between environmental BPA exposure and the altered behavior of children, a case-control study was conducted with children aged 6-12 years in Guangzhou, China. Two hundred fifteen children diagnosed with ADHD and 253 healthy children from Guangzhou were recruited as the case and control groups, respectively. Urinary BPA and 8-hydroxy-2'-deoxyguanosine (8-OHdG, a biomarker of oxidative DNA damage) concentrations were determined by high-performance liquid chromatography/tandem spectrometry. The results showed that concentrations of urinary BPA for the case group were significantly higher than those for the control group (3.44 vs 1.70 μg/L; 4.63 vs 1.71 μg/g Crt. p < .001). A stepwise increase in the odds ratios for ADHD was observed with the increasing quartiles of children's urinary BPA (first quartile: reference category; second quartile adjusted OR: 1.79, 95% CI: 0.95-3.37; third quartile adjusted OR: 7.44, 95% CI: 3.91-14.1; fourth quartile adjusted OR: 9.41, 95% CI: 4.91-18.1). When the BPA levels were stratified by gender, the odds of ADHD among boys and girls increased significantly with urinary BPA concentrations (adjusted OR: 4.58, 95% CI: 2.84-7.37; adjusted OR: 2.83, 95% CI: 1.17-6.84). Urinary 8-OHdG concentrations in the ADHD children were significantly higher than those in the control group. Furthermore, the linear regression analysis results indicated that a significant relationship existed between BPA exposure and 8-OHdG levels (R = 0.257, p < .001). Our findings provide direct evidence that childhood BPA exposure may be related to ADHD and 8-OHdG concentrations for children. Moreover, BPA exposure could increase the higher occurrence of ADHD for boy than for girls.

Authors+Show Affiliations

Guangzhou Key Laboratory of Subtropical Biodiversity and Biomonitoring, School of Life Sciences, South China Normal University, Guangzhou, 510631, China.Guangzhou Key Laboratory of Subtropical Biodiversity and Biomonitoring, School of Life Sciences, South China Normal University, Guangzhou, 510631, China.Guangzhou Key Laboratory of Subtropical Biodiversity and Biomonitoring, School of Life Sciences, South China Normal University, Guangzhou, 510631, China.Guangzhou Key Laboratory of Subtropical Biodiversity and Biomonitoring, School of Life Sciences, South China Normal University, Guangzhou, 510631, China. Electronic address: 20001047@m.scnu.edu.cn.Psychology Department, Guangzhou Women and Children's Medical Center, Guangzhou, 510623, China. Electronic address: Chach@sohu.com.Guangzhou Key Laboratory of Subtropical Biodiversity and Biomonitoring, School of Life Sciences, South China Normal University, Guangzhou, 510631, China; State Key Laboratory of Organic Geochemistry and Guangdong Key Laboratory of Environmental Protection and Resources Utilization, Guangzhou Institute of Geochemistry, Chinese Academy of Science, Guangzhou, 510640, China.Guangzhou Key Laboratory of Subtropical Biodiversity and Biomonitoring, School of Life Sciences, South China Normal University, Guangzhou, 510631, China; State Key Laboratory of Organic Geochemistry and Guangdong Key Laboratory of Environmental Protection and Resources Utilization, Guangzhou Institute of Geochemistry, Chinese Academy of Science, Guangzhou, 510640, China.Guangzhou Key Laboratory of Subtropical Biodiversity and Biomonitoring, School of Life Sciences, South China Normal University, Guangzhou, 510631, China; State Key Laboratory of Organic Geochemistry and Guangdong Key Laboratory of Environmental Protection and Resources Utilization, Guangzhou Institute of Geochemistry, Chinese Academy of Science, Guangzhou, 510640, China.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

29276960

Citation

Li, Yanru, et al. "Relationship Between Bisphenol a Exposure and Attention-deficit/ Hyperactivity Disorder: a Case-control Study for Primary School Children in Guangzhou, China." Environmental Pollution (Barking, Essex : 1987), vol. 235, 2018, pp. 141-149.
Li Y, Zhang H, Kuang H, et al. Relationship between bisphenol A exposure and attention-deficit/ hyperactivity disorder: A case-control study for primary school children in Guangzhou, China. Environ Pollut. 2018;235:141-149.
Li, Y., Zhang, H., Kuang, H., Fan, R., Cha, C., Li, G., Luo, Z., & Pang, Q. (2018). Relationship between bisphenol A exposure and attention-deficit/ hyperactivity disorder: A case-control study for primary school children in Guangzhou, China. Environmental Pollution (Barking, Essex : 1987), 235, 141-149. https://doi.org/10.1016/j.envpol.2017.12.056
Li Y, et al. Relationship Between Bisphenol a Exposure and Attention-deficit/ Hyperactivity Disorder: a Case-control Study for Primary School Children in Guangzhou, China. Environ Pollut. 2018;235:141-149. PubMed PMID: 29276960.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Relationship between bisphenol A exposure and attention-deficit/ hyperactivity disorder: A case-control study for primary school children in Guangzhou, China. AU - Li,Yanru, AU - Zhang,Haibin, AU - Kuang,Hongxuan, AU - Fan,Ruifang, AU - Cha,Caihui, AU - Li,Guanyong, AU - Luo,Zhiwei, AU - Pang,Qihua, Y1 - 2017/12/23/ PY - 2017/07/05/received PY - 2017/12/12/revised PY - 2017/12/15/accepted PY - 2017/12/26/pubmed PY - 2018/5/25/medline PY - 2017/12/26/entrez KW - 8-Hydroxy-2′- deoxyguanosine KW - Attention-deficit/hyperactivity disorder KW - Bisphenol A KW - Exposure KW - Urine SP - 141 EP - 149 JF - Environmental pollution (Barking, Essex : 1987) JO - Environ. Pollut. VL - 235 N2 - Bisphenol A (BPA) is an endocrine-disrupting chemical. Studies have shown that the exposure to BPA is associated with attention-deficit/hyperactivity disorder (ADHD) during adolescent development. However the direct clinical evidence is limited. To investigate the possible association between environmental BPA exposure and the altered behavior of children, a case-control study was conducted with children aged 6-12 years in Guangzhou, China. Two hundred fifteen children diagnosed with ADHD and 253 healthy children from Guangzhou were recruited as the case and control groups, respectively. Urinary BPA and 8-hydroxy-2'-deoxyguanosine (8-OHdG, a biomarker of oxidative DNA damage) concentrations were determined by high-performance liquid chromatography/tandem spectrometry. The results showed that concentrations of urinary BPA for the case group were significantly higher than those for the control group (3.44 vs 1.70 μg/L; 4.63 vs 1.71 μg/g Crt. p < .001). A stepwise increase in the odds ratios for ADHD was observed with the increasing quartiles of children's urinary BPA (first quartile: reference category; second quartile adjusted OR: 1.79, 95% CI: 0.95-3.37; third quartile adjusted OR: 7.44, 95% CI: 3.91-14.1; fourth quartile adjusted OR: 9.41, 95% CI: 4.91-18.1). When the BPA levels were stratified by gender, the odds of ADHD among boys and girls increased significantly with urinary BPA concentrations (adjusted OR: 4.58, 95% CI: 2.84-7.37; adjusted OR: 2.83, 95% CI: 1.17-6.84). Urinary 8-OHdG concentrations in the ADHD children were significantly higher than those in the control group. Furthermore, the linear regression analysis results indicated that a significant relationship existed between BPA exposure and 8-OHdG levels (R = 0.257, p < .001). Our findings provide direct evidence that childhood BPA exposure may be related to ADHD and 8-OHdG concentrations for children. Moreover, BPA exposure could increase the higher occurrence of ADHD for boy than for girls. SN - 1873-6424 UR - https://www.unboundmedicine.com/medline/citation/29276960/Relationship_between_bisphenol_A_exposure_and_attention_deficit/_hyperactivity_disorder:_A_case_control_study_for_primary_school_children_in_Guangzhou_China_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0269-7491(17)32788-4 DB - PRIME DP - Unbound Medicine ER -