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Gasotransmitters: Physiological Role and Involvement in the Pathogenesis of the Diseases.
Usp Fiziol Nauk. 2016 Jul-Sep; 47(3):30-58.UF

Abstract

In recent decades, it has been found the existence of a new class of biologically active substances - gaseous mediators (gasotransmitters), performing in the cells the signaling function and with high specificity involved in the intercellular and intracellular communication. This review characterizes the main gasotransmitters: nitric oxide, carbon monoxide, hydrogen sulfide, sulfur dioxide and polysulfides. Their physiological role and involvement in the pathogenesis of diseases is described. Basic information about main gasotransmitters is generalized in the original table. Nitrate-Nitrite background, which is a chemical background of the existence of modern man, affects the intra- and intercellular signaling system, alters the ultrastructure of neurons, neuron-neuron and neuron-glia interaction, eliminates the effects of endogenous gasotransmitters and affects the average life expectancy. In accordance with the principle of cyclicity is proposed and substantiated the hypothesis of the existence of “hydrogen sulfide cycle”, combining three sulfur-containing gasotransmitters. It is suggested that the cyclic organization of gasotransmitters in the cells and the whole body can be due to the existence of a global principle of cyclicity, which can spread its influence on almost all the structural and functional levels in the animate and inanimate nature.

Authors

No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Review

Language

rus

PubMed ID

29283229

Citation

Sukmansky, O I., and V P. Reutov. "Gasotransmitters: Physiological Role and Involvement in the Pathogenesis of the Diseases." Uspekhi Fiziologicheskikh Nauk, vol. 47, no. 3, 2016, pp. 30-58.
Sukmansky OI, Reutov VP. Gasotransmitters: Physiological Role and Involvement in the Pathogenesis of the Diseases. Usp Fiziol Nauk. 2016;47(3):30-58.
Sukmansky, O. I., & Reutov, V. P. (2016). Gasotransmitters: Physiological Role and Involvement in the Pathogenesis of the Diseases. Uspekhi Fiziologicheskikh Nauk, 47(3), 30-58.
Sukmansky OI, Reutov VP. Gasotransmitters: Physiological Role and Involvement in the Pathogenesis of the Diseases. Usp Fiziol Nauk. 2016 Jul-Sep;47(3):30-58. PubMed PMID: 29283229.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Gasotransmitters: Physiological Role and Involvement in the Pathogenesis of the Diseases. AU - Sukmansky,O I, AU - Reutov,V P, PY - 2017/12/29/entrez PY - 2016/7/1/pubmed PY - 2018/1/18/medline SP - 30 EP - 58 JF - Uspekhi fiziologicheskikh nauk JO - Usp Fiziol Nauk VL - 47 IS - 3 N2 - In recent decades, it has been found the existence of a new class of biologically active substances - gaseous mediators (gasotransmitters), performing in the cells the signaling function and with high specificity involved in the intercellular and intracellular communication. This review characterizes the main gasotransmitters: nitric oxide, carbon monoxide, hydrogen sulfide, sulfur dioxide and polysulfides. Their physiological role and involvement in the pathogenesis of diseases is described. Basic information about main gasotransmitters is generalized in the original table. Nitrate-Nitrite background, which is a chemical background of the existence of modern man, affects the intra- and intercellular signaling system, alters the ultrastructure of neurons, neuron-neuron and neuron-glia interaction, eliminates the effects of endogenous gasotransmitters and affects the average life expectancy. In accordance with the principle of cyclicity is proposed and substantiated the hypothesis of the existence of “hydrogen sulfide cycle”, combining three sulfur-containing gasotransmitters. It is suggested that the cyclic organization of gasotransmitters in the cells and the whole body can be due to the existence of a global principle of cyclicity, which can spread its influence on almost all the structural and functional levels in the animate and inanimate nature. SN - 0301-1798 UR - https://www.unboundmedicine.com/medline/citation/29283229/Gasotransmitters:_Physiological_Role_and_Involvement_in_the_Pathogenesis_of_the_Diseases_ DB - PRIME DP - Unbound Medicine ER -