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Migraine and subsequent chronic kidney disease risk: a nationwide population-based cohort study.
BMJ Open 2017; 7(12):e018483BO

Abstract

OBJECTIVE

We compared the incidence and risk of chronic kidney disease (CKD) between subjects with new-onset migraine and matched controls without migraine in this large-scale retrospective cohort study.

DESIGN

Population-based cohort study.

SETTING

8880 subjects with migraine and 503 070 subjects without migraine were enrolled between January 1, 2000 and December 31, 2013, all diagnosed to be without kidney disease. All the participants were registered in the National Health Insurance Research Database.

PARTICIPANTS

Finally, data from 7156 subjects with migraine and 7156 propensity-score-matched control subjects were analysed.

PRIMARY OUTCOME MEASURE

We used Cox proportional hazards regression to estimate adjusted HRs for incident CKD; subgroup analyses were performed to assess the interactive effects of migraine with demographics, comorbidities and long-term medications.

RESULTS

The incidence of CKD was higher in the migraine group than in the control group. The risk of developing CKD was significantly higher in subjects with migraine than without migraine (P=0.031). Subjects with migraine aged <65 years (age 40-64 (adjusted HR (aHR) 1.35; 95% CI 1.05 to 1.73); age <40 (aHR 1.55; 95% CI 1.02 to 2.36)), with ≥1 comorbid diseases (1-2 diseases (aHR 1.30; 95% CI 1.01 to 1.68); ≥3 diseases (aHR 1.45; 95% CI 1.01 to 2.07)), and not receiving anti-migraine agents (aHR 1.26; 95% CI 1.04 to 1.54) were at a higher risk of developing CKD compared with the control subjects. The interaction between migraine and comorbidities was not significant; age, male gender and long-term use of non-steroidal anti-inflammatory drugs (NSAIDs) were independent risk factors for CKD in subjects with migraine.

CONCLUSION

Migraine may be an independent risk factor for CKD. Young subjects with migraine, and those with comorbid conditions or without medical control, are likely to be at higher risk for CKD. Ageing, male sex and NSAIDs tend to have an association with CKD in subjects with migraine.

Authors+Show Affiliations

Institute of Clinical Medicine, National Yang-Ming University, Taipei, Taiwan. Department of Internal Medicine, Center for Geriatrics and Gerontology, Division of Nephrology, Taichung Veterans General Hospital, Taichung, Taiwan.Institute of Clinical Medicine, National Yang-Ming University, Taipei, Taiwan. Department of Internal Medicine, Division of Nephrology, Changhua Christian Hospital, Changhua, Taiwan. School of Medicine, Chung-Shan Medical University, Taichung, Taiwan. Internal Medicine Research Center, Changhua Christian Hospital, Changhua, Taiwan.Internal Medicine Research Center, Changhua Christian Hospital, Changhua, Taiwan.Department of Internal Medicine, Division of Nephrology, Changhua Christian Hospital, Changhua, Taiwan. School of Medicine, Chung-Shan Medical University, Taichung, Taiwan. Internal Medicine Research Center, Changhua Christian Hospital, Changhua, Taiwan.Institute of Clinical Medicine, National Yang-Ming University, Taipei, Taiwan. Department of Internal Medicine, Center for Geriatrics and Gerontology, Division of Nephrology, Taichung Veterans General Hospital, Taichung, Taiwan. School of Medicine, Chung-Shan Medical University, Taichung, Taiwan.Department of Internal Medicine, Division of Nephrology, Changhua Christian Hospital, Changhua, Taiwan. School of Medicine, Chung-Shan Medical University, Taichung, Taiwan. Internal Medicine Research Center, Changhua Christian Hospital, Changhua, Taiwan.Institute of Clinical Medicine, National Yang-Ming University, Taipei, Taiwan. Department and Institute of Physiology, National Yang-Ming University, Taipei, Taiwan. Department of Medicine, Division of Nephrology, Taipei Veterans General Hospital, Taipei, Taiwan.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

29284721

Citation

Weng, Shuo-Chun, et al. "Migraine and Subsequent Chronic Kidney Disease Risk: a Nationwide Population-based Cohort Study." BMJ Open, vol. 7, no. 12, 2017, pp. e018483.
Weng SC, Wu CL, Kor CT, et al. Migraine and subsequent chronic kidney disease risk: a nationwide population-based cohort study. BMJ Open. 2017;7(12):e018483.
Weng, S. C., Wu, C. L., Kor, C. T., Chiu, P. F., Wu, M. J., Chang, C. C., & Tarng, D. C. (2017). Migraine and subsequent chronic kidney disease risk: a nationwide population-based cohort study. BMJ Open, 7(12), pp. e018483. doi:10.1136/bmjopen-2017-018483.
Weng SC, et al. Migraine and Subsequent Chronic Kidney Disease Risk: a Nationwide Population-based Cohort Study. BMJ Open. 2017 12 27;7(12):e018483. PubMed PMID: 29284721.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Migraine and subsequent chronic kidney disease risk: a nationwide population-based cohort study. AU - Weng,Shuo-Chun, AU - Wu,Chia-Lin, AU - Kor,Chew-Teng, AU - Chiu,Ping-Fang, AU - Wu,Ming-Ju, AU - Chang,Chia-Chu, AU - Tarng,Der-Cherng, Y1 - 2017/12/27/ PY - 2017/12/30/entrez PY - 2017/12/30/pubmed PY - 2018/8/14/medline KW - anti-migraine agents KW - chronic kidney disease KW - migraine KW - national health insurance research database KW - propensity score SP - e018483 EP - e018483 JF - BMJ open JO - BMJ Open VL - 7 IS - 12 N2 - OBJECTIVE: We compared the incidence and risk of chronic kidney disease (CKD) between subjects with new-onset migraine and matched controls without migraine in this large-scale retrospective cohort study. DESIGN: Population-based cohort study. SETTING: 8880 subjects with migraine and 503 070 subjects without migraine were enrolled between January 1, 2000 and December 31, 2013, all diagnosed to be without kidney disease. All the participants were registered in the National Health Insurance Research Database. PARTICIPANTS: Finally, data from 7156 subjects with migraine and 7156 propensity-score-matched control subjects were analysed. PRIMARY OUTCOME MEASURE: We used Cox proportional hazards regression to estimate adjusted HRs for incident CKD; subgroup analyses were performed to assess the interactive effects of migraine with demographics, comorbidities and long-term medications. RESULTS: The incidence of CKD was higher in the migraine group than in the control group. The risk of developing CKD was significantly higher in subjects with migraine than without migraine (P=0.031). Subjects with migraine aged <65 years (age 40-64 (adjusted HR (aHR) 1.35; 95% CI 1.05 to 1.73); age <40 (aHR 1.55; 95% CI 1.02 to 2.36)), with ≥1 comorbid diseases (1-2 diseases (aHR 1.30; 95% CI 1.01 to 1.68); ≥3 diseases (aHR 1.45; 95% CI 1.01 to 2.07)), and not receiving anti-migraine agents (aHR 1.26; 95% CI 1.04 to 1.54) were at a higher risk of developing CKD compared with the control subjects. The interaction between migraine and comorbidities was not significant; age, male gender and long-term use of non-steroidal anti-inflammatory drugs (NSAIDs) were independent risk factors for CKD in subjects with migraine. CONCLUSION: Migraine may be an independent risk factor for CKD. Young subjects with migraine, and those with comorbid conditions or without medical control, are likely to be at higher risk for CKD. Ageing, male sex and NSAIDs tend to have an association with CKD in subjects with migraine. SN - 2044-6055 UR - https://www.unboundmedicine.com/medline/citation/29284721/Migraine_and_subsequent_chronic_kidney_disease_risk:_a_nationwide_population_based_cohort_study_ L2 - http://bmjopen.bmj.com/cgi/pmidlookup?view=long&amp;pmid=29284721 DB - PRIME DP - Unbound Medicine ER -