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Upregulation of peroxisome proliferator activated receptor alpha by fenofibrate in induced testicular ischemia reperfusion.
Biomed Pharmacother. 2018 Feb; 98:507-515.BP

Abstract

Torsion of the spermatic cord is a common urological emergency among infants and adolescents that can lead to testicular necrosis and infertility. We investigated the effect of fenofibrate (FEN) on induced testicular ischemia reperfusion (testicular (I-R). FEN (100, 300 mg/kg/day) was administered orally in presence or absence of testicular (I-R). We measured testicular weight changes and serum testosterone level. In addition; Testicular tissue reduced glutathione (GSH), malondialdehyde (MDA), total nitrites (NOx) and superoxide dismutase (SOD) activity were measured. Moreover; tumor necrosis factor alpha (TNF-α), nuclear factor kappa B (NF-κB) immunoexpressions and histopathology were evaluated. Testicular (I-R) induced group showed significant decrease in serum testosterone level and testicular weight with increase in testicular tissue MDA and NOx levels. Testicular (I-R) induced group showed the histopathological changes of marked testicular damage according to Johnsen's score. In addition, there was significant reduction in GSH and SOD testicular tissue levels but significant increase in TNF-α and NF-κB immunoexpressions. FEN was able to markedly improve testicular (I-R) induced changes through its action on peroxisome proliferator activated receptor alpha (PPARα), anti-oxidant, anti-inflammatory and anti-apoptotic effects.

Authors+Show Affiliations

Department of Pharmacology, Faculty of Medicine, Minia University, 61511, Minia, Egypt. Electronic address: marwamonier@yahoo.com.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

29287198

Citation

Refaie, Marwa M M.. "Upregulation of Peroxisome Proliferator Activated Receptor Alpha By Fenofibrate in Induced Testicular Ischemia Reperfusion." Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie, vol. 98, 2018, pp. 507-515.
Refaie MMM. Upregulation of peroxisome proliferator activated receptor alpha by fenofibrate in induced testicular ischemia reperfusion. Biomed Pharmacother. 2018;98:507-515.
Refaie, M. M. M. (2018). Upregulation of peroxisome proliferator activated receptor alpha by fenofibrate in induced testicular ischemia reperfusion. Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie, 98, 507-515. https://doi.org/10.1016/j.biopha.2017.12.093
Refaie MMM. Upregulation of Peroxisome Proliferator Activated Receptor Alpha By Fenofibrate in Induced Testicular Ischemia Reperfusion. Biomed Pharmacother. 2018;98:507-515. PubMed PMID: 29287198.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Upregulation of peroxisome proliferator activated receptor alpha by fenofibrate in induced testicular ischemia reperfusion. A1 - Refaie,Marwa M M, Y1 - 2017/12/27/ PY - 2017/09/09/received PY - 2017/12/15/revised PY - 2017/12/19/accepted PY - 2017/12/30/pubmed PY - 2018/8/14/medline PY - 2017/12/30/entrez KW - Fenofibrate KW - Peroxisome proliferator activated receptor alpha KW - Testicular ischemia reperfusion KW - Testosterone SP - 507 EP - 515 JF - Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie JO - Biomed Pharmacother VL - 98 N2 - Torsion of the spermatic cord is a common urological emergency among infants and adolescents that can lead to testicular necrosis and infertility. We investigated the effect of fenofibrate (FEN) on induced testicular ischemia reperfusion (testicular (I-R). FEN (100, 300 mg/kg/day) was administered orally in presence or absence of testicular (I-R). We measured testicular weight changes and serum testosterone level. In addition; Testicular tissue reduced glutathione (GSH), malondialdehyde (MDA), total nitrites (NOx) and superoxide dismutase (SOD) activity were measured. Moreover; tumor necrosis factor alpha (TNF-α), nuclear factor kappa B (NF-κB) immunoexpressions and histopathology were evaluated. Testicular (I-R) induced group showed significant decrease in serum testosterone level and testicular weight with increase in testicular tissue MDA and NOx levels. Testicular (I-R) induced group showed the histopathological changes of marked testicular damage according to Johnsen's score. In addition, there was significant reduction in GSH and SOD testicular tissue levels but significant increase in TNF-α and NF-κB immunoexpressions. FEN was able to markedly improve testicular (I-R) induced changes through its action on peroxisome proliferator activated receptor alpha (PPARα), anti-oxidant, anti-inflammatory and anti-apoptotic effects. SN - 1950-6007 UR - https://www.unboundmedicine.com/medline/citation/29287198/Upregulation_of_peroxisome_proliferator_activated_receptor_alpha_by_fenofibrate_in_induced_testicular_ischemia_reperfusion_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0753-3322(17)34671-1 DB - PRIME DP - Unbound Medicine ER -