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Effect of conjugated linoleic acid on blood inflammatory markers: a systematic review and meta-analysis on randomized controlled trials.
Eur J Clin Nutr. 2018 08; 72(8):1071-1082.EJ

Abstract

BACKGROUND/OBJECTIVES

Conjugated linoleic acid (CLA) is a polyunsaturated fatty acid with attractive biological activities. Numerous studies have been conducted on the inflammation-lowering effects of CLA in in vitro and animal models. However, the effects of CLA treatment on the inflammatory markers in humans are controversial. Therefore, the objective of this study was to perform a systematic review and meta-analysis on controlled clinical trials (RCT) assessing the effects of CLA supplementation on the circulating inflammatory markers, including C-reactive protein (CRP), interleukin-6 (IL-6), and tumor necrosis factor-α (TNF-α).

SUBJECTS/METHODS

The literature search of RCTs was performed using Pubmed/Medline, Scopus, ScienceDirect, Web of science, Cochrane, and Google Scholar databases from inception to March 2017. Weighted mean differences were estimated and the pooled effect size was calculated by a random effects model.

RESULTS

Of the 427 identified studies, eleven RCTs, including 420 subjects were included in the statistical analysis. Findings suggested that CLA supplementation increased blood levels of CRP by 0.89 mg/l (95% CI: 0.11, 1.68; P = 0.025) and TNF-α levels by 0.39 pg/ml (95% CI: 0.23, 0.55; P < 0.0001). However, blood IL-6 levels were marginally decreased by 0.32 pg/ml (95% CI: -0.71, 0.07; P = 0.11) following CLA supplementation. There was a significant heterogeneity for the impact of CLA on CRP and IL-6, but not TNF-α.

CONCLUSIONS

This meta-analysis showed that CLA supplementation may increase inflammatory markers (CRP and TNF-α). There are concerns about using CLA supplementation as an anti-obesity agent among the obese population for at least a short duration.

Authors+Show Affiliations

Food Security Research Center, Isfahan University of Medical Sciences, Isfahan, Iran. Department of Community Nutrition, School of Nutrition and Food Science, Isfahan University of Medical Sciences, Isfahan, Iran.Department of Basic Medical Sciences, Neyshabur University of Medical Sciences, Neyshabur, Iran. fatemeh.nobakht@yahoo.com.

Pub Type(s)

Journal Article
Meta-Analysis
Systematic Review

Language

eng

PubMed ID

29288248

Citation

Haghighatdoost, Fahimeh, and B Fatemeh Nobakht M Gh. "Effect of Conjugated Linoleic Acid On Blood Inflammatory Markers: a Systematic Review and Meta-analysis On Randomized Controlled Trials." European Journal of Clinical Nutrition, vol. 72, no. 8, 2018, pp. 1071-1082.
Haghighatdoost F, Nobakht M Gh BF. Effect of conjugated linoleic acid on blood inflammatory markers: a systematic review and meta-analysis on randomized controlled trials. Eur J Clin Nutr. 2018;72(8):1071-1082.
Haghighatdoost, F., & Nobakht M Gh, B. F. (2018). Effect of conjugated linoleic acid on blood inflammatory markers: a systematic review and meta-analysis on randomized controlled trials. European Journal of Clinical Nutrition, 72(8), 1071-1082. https://doi.org/10.1038/s41430-017-0048-z
Haghighatdoost F, Nobakht M Gh BF. Effect of Conjugated Linoleic Acid On Blood Inflammatory Markers: a Systematic Review and Meta-analysis On Randomized Controlled Trials. Eur J Clin Nutr. 2018;72(8):1071-1082. PubMed PMID: 29288248.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of conjugated linoleic acid on blood inflammatory markers: a systematic review and meta-analysis on randomized controlled trials. AU - Haghighatdoost,Fahimeh, AU - Nobakht M Gh,B Fatemeh, Y1 - 2017/12/29/ PY - 2017/06/14/received PY - 2017/11/06/accepted PY - 2017/10/10/revised PY - 2017/12/31/pubmed PY - 2019/5/14/medline PY - 2017/12/31/entrez SP - 1071 EP - 1082 JF - European journal of clinical nutrition JO - Eur J Clin Nutr VL - 72 IS - 8 N2 - BACKGROUND/OBJECTIVES: Conjugated linoleic acid (CLA) is a polyunsaturated fatty acid with attractive biological activities. Numerous studies have been conducted on the inflammation-lowering effects of CLA in in vitro and animal models. However, the effects of CLA treatment on the inflammatory markers in humans are controversial. Therefore, the objective of this study was to perform a systematic review and meta-analysis on controlled clinical trials (RCT) assessing the effects of CLA supplementation on the circulating inflammatory markers, including C-reactive protein (CRP), interleukin-6 (IL-6), and tumor necrosis factor-α (TNF-α). SUBJECTS/METHODS: The literature search of RCTs was performed using Pubmed/Medline, Scopus, ScienceDirect, Web of science, Cochrane, and Google Scholar databases from inception to March 2017. Weighted mean differences were estimated and the pooled effect size was calculated by a random effects model. RESULTS: Of the 427 identified studies, eleven RCTs, including 420 subjects were included in the statistical analysis. Findings suggested that CLA supplementation increased blood levels of CRP by 0.89 mg/l (95% CI: 0.11, 1.68; P = 0.025) and TNF-α levels by 0.39 pg/ml (95% CI: 0.23, 0.55; P < 0.0001). However, blood IL-6 levels were marginally decreased by 0.32 pg/ml (95% CI: -0.71, 0.07; P = 0.11) following CLA supplementation. There was a significant heterogeneity for the impact of CLA on CRP and IL-6, but not TNF-α. CONCLUSIONS: This meta-analysis showed that CLA supplementation may increase inflammatory markers (CRP and TNF-α). There are concerns about using CLA supplementation as an anti-obesity agent among the obese population for at least a short duration. SN - 1476-5640 UR - https://www.unboundmedicine.com/medline/citation/29288248/Effect_of_conjugated_linoleic_acid_on_blood_inflammatory_markers:_a_systematic_review_and_meta_analysis_on_randomized_controlled_trials_ DB - PRIME DP - Unbound Medicine ER -