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Higher dietary total antioxidant capacity is inversely related to prediabetes: A case-control study.
Nutrition. 2018 02; 46:20-25.N

Abstract

OBJECTIVES

Dietary total antioxidant capacity (DTAC) has been proposed as a tool for assessing the intake of antioxidants. The relationship between DTAC and blood glucose levels has been investigated mostly in healthy people. The aim of this study was to evaluate the association between DTAC and prediabetes morbidity in a case-control study.

METHODS

We examined 300 individuals with and without prediabetes (n = 150/group) who attended a Diabetes Screening Center in Shahreza, Iran. The anthropometric measures, physical activity, and blood glucose levels of all participants were measured. Food intake over the previous year was determined using a semiquantitative food frequency questionnaire, and sex-specific, energy-adjusted DTAC was calculated using the U.S. Department of Agriculture's database. Logistic reg/ression was used to model the relationship between DTAC and prediabetes morbidity.

RESULTS

The mean DTAC was significantly lower in individuals with prediabetes than in the control group (P < 0.001). Across increasing DTAC quartiles, the participants had lower fasting blood glucose and 2-h postchallenge plasma glucose (Ptrend < 0.02). After adjustment for body mass index; physical activity; education; dietary intake of fiber, fat, energy, and coffee; participants in the fourth quartile of DTAC were less likely to experience prediabetes compared with those in the first quartile (odds ratio, 0.18; 95% confidence interval, 0.07-0.49).

CONCLUSION

The DTAC score appears useful when assessing the antioxidant capacity of diet and to better understand the relationship between diet and prediabetes morbidity. Future studies are needed to confirm the findings from the present study in other populations.

Authors+Show Affiliations

Department of Community Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran. Electronic address: Gsotodeh@tums.ac.ir.Department of Community Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran.Department of Community Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran.Department of Community Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran.Department of Cellular, Molecular Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran.Department of Community Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

29290350

Citation

Sotoudeh, Gity, et al. "Higher Dietary Total Antioxidant Capacity Is Inversely Related to Prediabetes: a Case-control Study." Nutrition (Burbank, Los Angeles County, Calif.), vol. 46, 2018, pp. 20-25.
Sotoudeh G, Abshirini M, Bagheri F, et al. Higher dietary total antioxidant capacity is inversely related to prediabetes: A case-control study. Nutrition. 2018;46:20-25.
Sotoudeh, G., Abshirini, M., Bagheri, F., Siassi, F., Koohdani, F., & Aslany, Z. (2018). Higher dietary total antioxidant capacity is inversely related to prediabetes: A case-control study. Nutrition (Burbank, Los Angeles County, Calif.), 46, 20-25. https://doi.org/10.1016/j.nut.2017.08.005
Sotoudeh G, et al. Higher Dietary Total Antioxidant Capacity Is Inversely Related to Prediabetes: a Case-control Study. Nutrition. 2018;46:20-25. PubMed PMID: 29290350.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Higher dietary total antioxidant capacity is inversely related to prediabetes: A case-control study. AU - Sotoudeh,Gity, AU - Abshirini,Maryam, AU - Bagheri,Fariba, AU - Siassi,Fereydoun, AU - Koohdani,Fariba, AU - Aslany,Zahra, Y1 - 2017/08/10/ PY - 2017/02/08/received PY - 2017/07/13/revised PY - 2017/08/06/accepted PY - 2018/1/2/entrez PY - 2018/1/2/pubmed PY - 2019/10/8/medline KW - Dietary total antioxidant capacity KW - Fasting blood sugar KW - Oxidative stress KW - Prediabetes SP - 20 EP - 25 JF - Nutrition (Burbank, Los Angeles County, Calif.) JO - Nutrition VL - 46 N2 - OBJECTIVES: Dietary total antioxidant capacity (DTAC) has been proposed as a tool for assessing the intake of antioxidants. The relationship between DTAC and blood glucose levels has been investigated mostly in healthy people. The aim of this study was to evaluate the association between DTAC and prediabetes morbidity in a case-control study. METHODS: We examined 300 individuals with and without prediabetes (n = 150/group) who attended a Diabetes Screening Center in Shahreza, Iran. The anthropometric measures, physical activity, and blood glucose levels of all participants were measured. Food intake over the previous year was determined using a semiquantitative food frequency questionnaire, and sex-specific, energy-adjusted DTAC was calculated using the U.S. Department of Agriculture's database. Logistic reg/ression was used to model the relationship between DTAC and prediabetes morbidity. RESULTS: The mean DTAC was significantly lower in individuals with prediabetes than in the control group (P < 0.001). Across increasing DTAC quartiles, the participants had lower fasting blood glucose and 2-h postchallenge plasma glucose (Ptrend < 0.02). After adjustment for body mass index; physical activity; education; dietary intake of fiber, fat, energy, and coffee; participants in the fourth quartile of DTAC were less likely to experience prediabetes compared with those in the first quartile (odds ratio, 0.18; 95% confidence interval, 0.07-0.49). CONCLUSION: The DTAC score appears useful when assessing the antioxidant capacity of diet and to better understand the relationship between diet and prediabetes morbidity. Future studies are needed to confirm the findings from the present study in other populations. SN - 1873-1244 UR - https://www.unboundmedicine.com/medline/citation/29290350/Higher_dietary_total_antioxidant_capacity_is_inversely_related_to_prediabetes:_A_case_control_study_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0899-9007(17)30172-7 DB - PRIME DP - Unbound Medicine ER -