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Laparoscopic ovarian drilling reduces serum homocysteine levels in women with Polycystic Ovary Syndrome.
Eur J Obstet Gynecol Reprod Biol. 2018 Feb; 221:135-138.EJ

Abstract

OBJECTIVE

To investigate the effect of laparoscopic ovarian drilling (LOD) on homocysteine levels and clinical outcomes in women with Polycystic Ovary Syndrome (PCOS).

STUDY DESIGN

The study was conducted in JIPMER, Puducherry. Fifty PCOS subjects who were admitted for LOD were enrolled in the study. Serum homocysteine levels were estimated in all the subjects before and after LOD. Paired t-test was used to compare the homocysteine levels before and after LOD.

RESULTS

LOD reduces homocysteine levels (p < .001), improves the rate of ovulation (38/50) and clinical pregnancy (21/50) in PCOS. When subgroup analysis was done, LOD significantly reduced homocysteine levels in ovulatory and conceived groups. Between the conceived and non conceived groups, the reduction was more significant (p = 0.001) in conceived group, when compared with non conceived group.

CONCLUSIONS

LOD reduces homocysteine levels and improves clinical outcome in PCOS.

Authors+Show Affiliations

Department of Obstetrics and Gynecology and Biochemistry, Jawaharlal Institute of Postgraduate Medical Education and Research, Puducherry, 605006, India. Electronic address: drchitra@yahoo.com.Department of Obstetrics and Gynecology and Biochemistry, Jawaharlal Institute of Postgraduate Medical Education and Research, Puducherry, 605006, India.Department of Obstetrics and Gynecology and Biochemistry, Jawaharlal Institute of Postgraduate Medical Education and Research, Puducherry, 605006, India.Department of Obstetrics and Gynecology and Biochemistry, Jawaharlal Institute of Postgraduate Medical Education and Research, Puducherry, 605006, India.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

29291589

Citation

Chitra, T, et al. "Laparoscopic Ovarian Drilling Reduces Serum Homocysteine Levels in Women With Polycystic Ovary Syndrome." European Journal of Obstetrics, Gynecology, and Reproductive Biology, vol. 221, 2018, pp. 135-138.
Chitra T, Papa D, Sinha P, et al. Laparoscopic ovarian drilling reduces serum homocysteine levels in women with Polycystic Ovary Syndrome. Eur J Obstet Gynecol Reprod Biol. 2018;221:135-138.
Chitra, T., Papa, D., Sinha, P., & Nandeesha, H. (2018). Laparoscopic ovarian drilling reduces serum homocysteine levels in women with Polycystic Ovary Syndrome. European Journal of Obstetrics, Gynecology, and Reproductive Biology, 221, 135-138. https://doi.org/10.1016/j.ejogrb.2017.12.048
Chitra T, et al. Laparoscopic Ovarian Drilling Reduces Serum Homocysteine Levels in Women With Polycystic Ovary Syndrome. Eur J Obstet Gynecol Reprod Biol. 2018;221:135-138. PubMed PMID: 29291589.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Laparoscopic ovarian drilling reduces serum homocysteine levels in women with Polycystic Ovary Syndrome. AU - Chitra,T, AU - Papa,Dasari, AU - Sinha,Priyanka, AU - Nandeesha,H, Y1 - 2017/12/27/ PY - 2017/03/25/received PY - 2017/12/26/revised PY - 2017/12/26/accepted PY - 2018/1/2/pubmed PY - 2018/9/8/medline PY - 2018/1/2/entrez KW - Homocysteine KW - Laparoscopic ovarian drilling KW - Ovulation KW - Polycystic ovary syndrome SP - 135 EP - 138 JF - European journal of obstetrics, gynecology, and reproductive biology JO - Eur. J. Obstet. Gynecol. Reprod. Biol. VL - 221 N2 - OBJECTIVE: To investigate the effect of laparoscopic ovarian drilling (LOD) on homocysteine levels and clinical outcomes in women with Polycystic Ovary Syndrome (PCOS). STUDY DESIGN: The study was conducted in JIPMER, Puducherry. Fifty PCOS subjects who were admitted for LOD were enrolled in the study. Serum homocysteine levels were estimated in all the subjects before and after LOD. Paired t-test was used to compare the homocysteine levels before and after LOD. RESULTS: LOD reduces homocysteine levels (p < .001), improves the rate of ovulation (38/50) and clinical pregnancy (21/50) in PCOS. When subgroup analysis was done, LOD significantly reduced homocysteine levels in ovulatory and conceived groups. Between the conceived and non conceived groups, the reduction was more significant (p = 0.001) in conceived group, when compared with non conceived group. CONCLUSIONS: LOD reduces homocysteine levels and improves clinical outcome in PCOS. SN - 1872-7654 UR - https://www.unboundmedicine.com/medline/citation/29291589/Laparoscopic_ovarian_drilling_reduces_serum_homocysteine_levels_in_women_with_Polycystic_Ovary_Syndrome L2 - https://linkinghub.elsevier.com/retrieve/pii/S0301-2115(17)30600-0 DB - PRIME DP - Unbound Medicine ER -