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Hematinic deficiencies and anemia statuses in anti-gastric parietal cell antibody-positive or all autoantibodies-negative erosive oral lichen planus patients.
J Formos Med Assoc. 2018 Mar; 117(3):227-234.JF

Abstract

BACKGROUND/PURPOSE

Approximately 27% of erosive oral lichen planus (EOLP) patients have serum anti-gastric parietal cell antibody (GPCA) positivity. This study assessed whether serum GPCA or EOLP itself was a significant factor that caused hematinic deficiencies and anemia statuses in GPCA-positive or autoantibodies-negative EOLP patients (GPCA+/EOLP and Abs-/EOLP patients).

METHODS

The mean corpuscular volume (MCV) and mean blood hemoglobin (Hb), iron, vitamin B12, and folic acid levels were measured and compared between any two of three groups of 41 GPCA+/EOLP patients, 198 Abs-/EOLP patients, and 184 healthy control subjects.

RESULTS

GPCA+/EOLP patients had significantly lower mean Hb, iron (for women only), and vitamin B12 level as well as significantly greater frequencies of Hb, iron, and vitamin B12 deficiencies than healthy control subjects. Moreover, GPCA+/EOLP patients had significantly lower serum vitamin B12 level and significantly higher MCV as well as a significantly greater frequency of vitamin B12 deficiency than Abs-/EOLP patients. Furthermore, Abs-/EOLP patients did have significantly lower mean Hb, MCV, iron (for women only), vitamin B12, and folic acid levels as well as significantly greater frequencies of Hb and iron deficiencies than healthy control subjects.

CONCLUSION

We conclude that serum GPCA is the major factor that causes vitamin B12 deficiency, macrocytosis and pernicious anemia in GPCA+/EOLP patients. Approximately 29-32% GPCA-positive EOLP patients have vitamin B12 deficiency or macrocytosis and about 23-25% vitamin B12 deficiency or macrocytosis EOLP patients have pernicious anemia. ELOP itself does play a significant role in causing anemia and hematinic deficiencies in Abs-/EOLP patients.

Authors+Show Affiliations

Graduate Institute of Clinical Dentistry, School of Dentistry, National Taiwan University, Taipei, Taiwan; Department of Dentistry, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei, Taiwan; Graduate Institute of Oral Biology, School of Dentistry, National Taiwan University, Taipei, Taiwan.Graduate Institute of Clinical Dentistry, School of Dentistry, National Taiwan University, Taipei, Taiwan; Department of Dentistry, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei, Taiwan; Graduate Institute of Oral Biology, School of Dentistry, National Taiwan University, Taipei, Taiwan.Graduate Institute of Clinical Dentistry, School of Dentistry, National Taiwan University, Taipei, Taiwan; Department of Dentistry, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei, Taiwan; Department of Dentistry, Far Eastern Memorial Hospital, New Taipei City, Taiwan.Institute of Epidemiology & Preventive Medicine, Department of Public Health, College of Public Health, National Taiwan University, Taiwan.Department of Dentistry, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei, Taiwan; Institute of Epidemiology & Preventive Medicine, Department of Public Health, College of Public Health, National Taiwan University, Taiwan.Graduate Institute of Clinical Dentistry, School of Dentistry, National Taiwan University, Taipei, Taiwan; Department of Dentistry, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei, Taiwan. Electronic address: andysun7702@yahoo.com.tw.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

29292055

Citation

Chang, Julia Yu-Fong, et al. "Hematinic Deficiencies and Anemia Statuses in Anti-gastric Parietal Cell Antibody-positive or All Autoantibodies-negative Erosive Oral Lichen Planus Patients." Journal of the Formosan Medical Association = Taiwan Yi Zhi, vol. 117, no. 3, 2018, pp. 227-234.
Chang JY, Wang YP, Wu YH, et al. Hematinic deficiencies and anemia statuses in anti-gastric parietal cell antibody-positive or all autoantibodies-negative erosive oral lichen planus patients. J Formos Med Assoc. 2018;117(3):227-234.
Chang, J. Y., Wang, Y. P., Wu, Y. H., Su, Y. X., Tu, Y. K., & Sun, A. (2018). Hematinic deficiencies and anemia statuses in anti-gastric parietal cell antibody-positive or all autoantibodies-negative erosive oral lichen planus patients. Journal of the Formosan Medical Association = Taiwan Yi Zhi, 117(3), 227-234. https://doi.org/10.1016/j.jfma.2017.12.009
Chang JY, et al. Hematinic Deficiencies and Anemia Statuses in Anti-gastric Parietal Cell Antibody-positive or All Autoantibodies-negative Erosive Oral Lichen Planus Patients. J Formos Med Assoc. 2018;117(3):227-234. PubMed PMID: 29292055.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Hematinic deficiencies and anemia statuses in anti-gastric parietal cell antibody-positive or all autoantibodies-negative erosive oral lichen planus patients. AU - Chang,Julia Yu-Fong, AU - Wang,Yi-Ping, AU - Wu,Yu-Hsueh, AU - Su,Yu-Xuan, AU - Tu,Yu-Kang, AU - Sun,Andy, Y1 - 2017/12/30/ PY - 2017/11/28/received PY - 2017/12/05/revised PY - 2017/12/13/accepted PY - 2018/1/3/pubmed PY - 2018/9/6/medline PY - 2018/1/3/entrez KW - Anti-gastric parietal cell antibody KW - Iron KW - Macrocytosis KW - Oral lichen planus KW - Pernicious anemia KW - Vitamin B12 deficiency SP - 227 EP - 234 JF - Journal of the Formosan Medical Association = Taiwan yi zhi JO - J Formos Med Assoc VL - 117 IS - 3 N2 - BACKGROUND/PURPOSE: Approximately 27% of erosive oral lichen planus (EOLP) patients have serum anti-gastric parietal cell antibody (GPCA) positivity. This study assessed whether serum GPCA or EOLP itself was a significant factor that caused hematinic deficiencies and anemia statuses in GPCA-positive or autoantibodies-negative EOLP patients (GPCA+/EOLP and Abs-/EOLP patients). METHODS: The mean corpuscular volume (MCV) and mean blood hemoglobin (Hb), iron, vitamin B12, and folic acid levels were measured and compared between any two of three groups of 41 GPCA+/EOLP patients, 198 Abs-/EOLP patients, and 184 healthy control subjects. RESULTS: GPCA+/EOLP patients had significantly lower mean Hb, iron (for women only), and vitamin B12 level as well as significantly greater frequencies of Hb, iron, and vitamin B12 deficiencies than healthy control subjects. Moreover, GPCA+/EOLP patients had significantly lower serum vitamin B12 level and significantly higher MCV as well as a significantly greater frequency of vitamin B12 deficiency than Abs-/EOLP patients. Furthermore, Abs-/EOLP patients did have significantly lower mean Hb, MCV, iron (for women only), vitamin B12, and folic acid levels as well as significantly greater frequencies of Hb and iron deficiencies than healthy control subjects. CONCLUSION: We conclude that serum GPCA is the major factor that causes vitamin B12 deficiency, macrocytosis and pernicious anemia in GPCA+/EOLP patients. Approximately 29-32% GPCA-positive EOLP patients have vitamin B12 deficiency or macrocytosis and about 23-25% vitamin B12 deficiency or macrocytosis EOLP patients have pernicious anemia. ELOP itself does play a significant role in causing anemia and hematinic deficiencies in Abs-/EOLP patients. SN - 0929-6646 UR - https://www.unboundmedicine.com/medline/citation/29292055/Hematinic_deficiencies_and_anemia_statuses_in_anti_gastric_parietal_cell_antibody_positive_or_all_autoantibodies_negative_erosive_oral_lichen_planus_patients_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0929-6646(17)30866-5 DB - PRIME DP - Unbound Medicine ER -