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Differences in portal hemodynamics in cirrhosis and idiopathic portal hypertension.
Am J Gastroenterol. 1989 Apr; 84(4):409-12.AJ

Abstract

A comparative study of portal hemodynamics was made in 79 cirrhotics (24 cirrhotics with a large spleen greater than or equal to 500 cm3 in volume, 55 cirrhotics with a spleen less than 500 cm3 in volume), 22 patients with idiopathic portal hypertension, and 63 healthy adults who served as the control for portal and splenic venous flows. Portal and splenic venous flows were significantly increased in the group order of the cirrhosis without splenomegaly group, the cirrhosis with splenomegaly group, and idiopathic portal hypertension group. Intrahepatic shunt index was significantly greater in the cirrhosis with splenomegaly group than in the cirrhosis without splenomegaly group, and it was negligible in the idiopathic portal hypertension group. Portal vein pressure was significantly elevated in the cirrhosis with splenomegaly group than in the cirrhosis without splenomegaly and idiopathic portal hypertension groups. Postsinusoidal resistances were significantly greater in the two groups of cirrhosis than in the idiopathic portal hypertension group, whereas presinusoidal resistance was significantly greater in the idiopathic portal hypertension group than in the two groups with cirrhosis. It is concluded that these differences are inconsistent with the view that cirrhosis with splenomegaly comes from idiopathic portal hypertension.

Authors+Show Affiliations

Ohnishi K
First Department of Medicine, Chiba University School of Medicine, Japan.
Chin N
No affiliation info available
Tanaka H
No affiliation info available
Iida S
No affiliation info available
Sato S
No affiliation info available
Terabayashi H
No affiliation info available
Nomura F
No affiliation info available

MeSH

FemaleHemodynamicsHumansHypertension, PortalLiver CirrhosisMaleMiddle AgedPortal SystemSplenomegaly

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

2929562

Citation

Ohnishi, K, et al. "Differences in Portal Hemodynamics in Cirrhosis and Idiopathic Portal Hypertension." The American Journal of Gastroenterology, vol. 84, no. 4, 1989, pp. 409-12.
Ohnishi K, Chin N, Tanaka H, et al. Differences in portal hemodynamics in cirrhosis and idiopathic portal hypertension. Am J Gastroenterol. 1989;84(4):409-12.
Ohnishi, K., Chin, N., Tanaka, H., Iida, S., Sato, S., Terabayashi, H., & Nomura, F. (1989). Differences in portal hemodynamics in cirrhosis and idiopathic portal hypertension. The American Journal of Gastroenterology, 84(4), 409-12.
Ohnishi K, et al. Differences in Portal Hemodynamics in Cirrhosis and Idiopathic Portal Hypertension. Am J Gastroenterol. 1989;84(4):409-12. PubMed PMID: 2929562.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Differences in portal hemodynamics in cirrhosis and idiopathic portal hypertension. AU - Ohnishi,K, AU - Chin,N, AU - Tanaka,H, AU - Iida,S, AU - Sato,S, AU - Terabayashi,H, AU - Nomura,F, PY - 1989/4/1/pubmed PY - 1989/4/1/medline PY - 1989/4/1/entrez SP - 409 EP - 12 JF - The American journal of gastroenterology JO - Am J Gastroenterol VL - 84 IS - 4 N2 - A comparative study of portal hemodynamics was made in 79 cirrhotics (24 cirrhotics with a large spleen greater than or equal to 500 cm3 in volume, 55 cirrhotics with a spleen less than 500 cm3 in volume), 22 patients with idiopathic portal hypertension, and 63 healthy adults who served as the control for portal and splenic venous flows. Portal and splenic venous flows were significantly increased in the group order of the cirrhosis without splenomegaly group, the cirrhosis with splenomegaly group, and idiopathic portal hypertension group. Intrahepatic shunt index was significantly greater in the cirrhosis with splenomegaly group than in the cirrhosis without splenomegaly group, and it was negligible in the idiopathic portal hypertension group. Portal vein pressure was significantly elevated in the cirrhosis with splenomegaly group than in the cirrhosis without splenomegaly and idiopathic portal hypertension groups. Postsinusoidal resistances were significantly greater in the two groups of cirrhosis than in the idiopathic portal hypertension group, whereas presinusoidal resistance was significantly greater in the idiopathic portal hypertension group than in the two groups with cirrhosis. It is concluded that these differences are inconsistent with the view that cirrhosis with splenomegaly comes from idiopathic portal hypertension. SN - 0002-9270 UR - https://www.unboundmedicine.com/medline/citation/2929562/Differences_in_portal_hemodynamics_in_cirrhosis_and_idiopathic_portal_hypertension_ DB - PRIME DP - Unbound Medicine ER -