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Bleeding pattern difference between levonorgestrel intrauterine system and copper intrauterine devices inserted immediately post-abortion: a multicenter, prospective, observational cohort study in Chinese women.
Curr Med Res Opin 2018; 34(5):873-880CM

Abstract

BACKGROUND

To describe the bleeding pattern (primary outcome), side effects, treatment satisfaction and 6 month continuity rates associated with the 52 mg levonorgestrel intrauterine system (LNG-IUS) and the copper intrauterine device (Cu-IUD) inserted immediately after abortion.

METHODS

This multicenter, prospective, observational cohort study enrolled healthy women (aged ≥18 years) inserted with LNG-IUS or Cu-IUD immediately after first-trimester surgical abortion and followed up to 6 months. Bleeding pattern was obtained through daily patient bleeding diaries.

RESULTS

From 2013 to 2014, we enrolled 512 women (LNG-IUS = 312 [median age: 32.0 years] and Cu-IUD = 200 [median age: 30.0 years]) from nine Chinese centers. LNG-IUS resulted in a significantly lower number of bleeding/spotting days in the second 90 day reference period compared with Cu-IUD (median 14.5 vs. 18.0 days, p < .0001). Amenorrhea rate (no bleeding/spotting day in the second 90 day reference period) and no menstrual bleeding rate (absence of bleeding days in the second 90 day reference period) were significantly higher in LNG-IUS compared to Cu-IUD (13.9% vs. 0% and 39.5% vs. 0%; p < .001 for all). No dysmenorrhea was higher at the last follow-up in LNG-IUS users than Cu-IUD users (81.2% vs. 76%; p = .0047). Both treatments had a high satisfaction rate among women at both the follow-up visits, and the majority of them continued with the treatment. The rates of adverse events (e.g. oligomenorrhea, amenorrhea) in the LNG-IUS and Cu-IUD groups were 77.2% and 44.5% (p < .0001), respectively.

CONCLUSION

LNG-IUS post-abortion shows better bleeding patterns, and reduced dysmenorrhea and bleeding amount, but with a similar safety profile compared with Cu-IUD. ClinicalTrials.gov identifier: NCT01958684.

Authors+Show Affiliations

a Family Planning Department , Jiangxi Maternal and Child Health hospital , Nanchang , China.b Obstetrics & Gynecology Department , Liuzhou Maternal and Child Health-Care Hospital , Liuzhou , China.c Obstetrics & Gynecology Department , Peking University Third Hospital , Beijing , China.d Family Planning Department , China International Peace Maternity and Child Health Hospital , Shanghai , China.e Obstetrics & Gynecology Department , Tongde Hospital of Zhejiang Province , Hangzhou , China.f Obstetrics & Gynecology Department , The Second Hospital of Hebei Medical University , Shijiazhuang , China.g Obstetrics & Gynecology Department , The Fourth Hospital of Shijiazhuang , Shijiazhuang , China.h Obstetrics & Gynecology Department , Chengdu Women's & Children's Central Hospital , Chengdu , China.i Family Planning Department , Beijing Obstetrics and Gynecology Hospital, Capital Medical University , Beijing , China.

Pub Type(s)

Comparative Study
Journal Article
Multicenter Study
Observational Study
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

29298525

Citation

Chen, Xiaoning, et al. "Bleeding Pattern Difference Between Levonorgestrel Intrauterine System and Copper Intrauterine Devices Inserted Immediately Post-abortion: a Multicenter, Prospective, Observational Cohort Study in Chinese Women." Current Medical Research and Opinion, vol. 34, no. 5, 2018, pp. 873-880.
Chen X, Li Q, Wang X, et al. Bleeding pattern difference between levonorgestrel intrauterine system and copper intrauterine devices inserted immediately post-abortion: a multicenter, prospective, observational cohort study in Chinese women. Curr Med Res Opin. 2018;34(5):873-880.
Chen, X., Li, Q., Wang, X., Chen, J., Lv, W., Shi, B., ... Li, J. (2018). Bleeding pattern difference between levonorgestrel intrauterine system and copper intrauterine devices inserted immediately post-abortion: a multicenter, prospective, observational cohort study in Chinese women. Current Medical Research and Opinion, 34(5), pp. 873-880. doi:10.1080/03007995.2017.1421919.
Chen X, et al. Bleeding Pattern Difference Between Levonorgestrel Intrauterine System and Copper Intrauterine Devices Inserted Immediately Post-abortion: a Multicenter, Prospective, Observational Cohort Study in Chinese Women. Curr Med Res Opin. 2018;34(5):873-880. PubMed PMID: 29298525.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Bleeding pattern difference between levonorgestrel intrauterine system and copper intrauterine devices inserted immediately post-abortion: a multicenter, prospective, observational cohort study in Chinese women. AU - Chen,Xiaoning, AU - Li,Qianxi, AU - Wang,Xiaoye, AU - Chen,Jing, AU - Lv,Wen, AU - Shi,Bin, AU - Wang,Hong, AU - Luo,Jianru, AU - Li,Jian, Y1 - 2018/02/07/ PY - 2018/1/5/pubmed PY - 2019/9/11/medline PY - 2018/1/5/entrez KW - Levonorgestrel-releasing intrauterine system KW - bleeding patterns KW - dysmenorrhea severity KW - satisfaction SP - 873 EP - 880 JF - Current medical research and opinion JO - Curr Med Res Opin VL - 34 IS - 5 N2 - BACKGROUND: To describe the bleeding pattern (primary outcome), side effects, treatment satisfaction and 6 month continuity rates associated with the 52 mg levonorgestrel intrauterine system (LNG-IUS) and the copper intrauterine device (Cu-IUD) inserted immediately after abortion. METHODS: This multicenter, prospective, observational cohort study enrolled healthy women (aged ≥18 years) inserted with LNG-IUS or Cu-IUD immediately after first-trimester surgical abortion and followed up to 6 months. Bleeding pattern was obtained through daily patient bleeding diaries. RESULTS: From 2013 to 2014, we enrolled 512 women (LNG-IUS = 312 [median age: 32.0 years] and Cu-IUD = 200 [median age: 30.0 years]) from nine Chinese centers. LNG-IUS resulted in a significantly lower number of bleeding/spotting days in the second 90 day reference period compared with Cu-IUD (median 14.5 vs. 18.0 days, p < .0001). Amenorrhea rate (no bleeding/spotting day in the second 90 day reference period) and no menstrual bleeding rate (absence of bleeding days in the second 90 day reference period) were significantly higher in LNG-IUS compared to Cu-IUD (13.9% vs. 0% and 39.5% vs. 0%; p < .001 for all). No dysmenorrhea was higher at the last follow-up in LNG-IUS users than Cu-IUD users (81.2% vs. 76%; p = .0047). Both treatments had a high satisfaction rate among women at both the follow-up visits, and the majority of them continued with the treatment. The rates of adverse events (e.g. oligomenorrhea, amenorrhea) in the LNG-IUS and Cu-IUD groups were 77.2% and 44.5% (p < .0001), respectively. CONCLUSION: LNG-IUS post-abortion shows better bleeding patterns, and reduced dysmenorrhea and bleeding amount, but with a similar safety profile compared with Cu-IUD. ClinicalTrials.gov identifier: NCT01958684. SN - 1473-4877 UR - https://www.unboundmedicine.com/medline/citation/29298525/Bleeding_pattern_difference_between_levonorgestrel_intrauterine_system_and_copper_intrauterine_devices_inserted_immediately_post_abortion:_a_multicenter_prospective_observational_cohort_study_in_Chinese_women_ L2 - http://www.tandfonline.com/doi/full/10.1080/03007995.2017.1421919 DB - PRIME DP - Unbound Medicine ER -