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Evaluation of the impact of glycemic status on the progression of coronary artery calcification in asymptomatic individuals.
Cardiovasc Diabetol. 2018 01 04; 17(1):4.CD

Abstract

BACKGROUND

Data on the influence of glycemic status on the progression of coronary calcification, an important marker for future adverse cardiovascular events, are limited.

METHODS

Data from the Korea Initiatives on Coronary Artery Calcification (KOICA) registry on 12,441 asymptomatic Korean adults (52 ± 9 years, 84.2% males) without previous history of coronary artery disease and stroke, who underwent serial coronary artery calcification (CAC) screening examinations, were included in this study. The median inter-scan period was 3.0 (2.0-4.8) years. All participants were categorized into three groups based on their glycemic status: normal (n = 6578), pre-diabetes (n = 4146), and diabetes (n = 1717). CAC progression was defined as a difference ≥ 2.5 between the square roots (√) of the baseline and follow-up CAC scores.

RESULTS

The incidence of CAC progression was significantly different between the three groups (normal, 26.3%; pre-diabetes, 30.9%; and diabetes, 46.9%; p < 0.001). In the univariate logistic analysis, the risk of CAC progression was higher in the pre-diabetes (odds ratio [OR] 1.253; 95% confidential interval [CI] 1.150-1.366) and diabetes (OR 2.471; 95% CI 2.215-2.758) groups than in the normal group (p < 0.001, both). In the multivariate logistic analysis, the risk of CAC progression was not significantly different between the normal and pre-diabetes groups but was significantly higher in the diabetes group than in the normal group.

CONCLUSIONS

In asymptomatic subjects, diabetes had an incremental impact on CAC progression; however, pre-diabetes did not increase the risk of CAC progression after adjusting for confounding factors.

Authors+Show Affiliations

Division of Cardiology, Ulsan University Hospital, University of Ulsan College of Medicine, Ulsan, South Korea. Division of Cardiology, Yonsei Cardiovascular Center, Yonsei University Health System, Seoul, South Korea.Division of Cardiology, Yonsei Cardiovascular Center, Yonsei University Health System, Seoul, South Korea.Division of Cardiology, Yonsei Cardiovascular Center, Yonsei University Health System, Seoul, South Korea.Division of Cardiology, Yonsei Cardiovascular Center, Yonsei University Health System, Seoul, South Korea.Division of Cardiology, Yonsei Cardiovascular Center, Yonsei University Health System, Seoul, South Korea.Division of Cardiology, Healthcare System Gangnam Center, Seoul National University Hospital, Seoul, South Korea.Division of Radiology, Seoul National University Bundang Hospital, Seongnam, South Korea.Division of Radiology, Gangnam Heartscan Clinic, Seoul, South Korea.Department of Internal Medicine, Gangnam Heartscan Clinic, Seoul, South Korea.Division of Cardiology, Heart Stroke & Vascular Institute, Samsung Medical Center, Seoul, South Korea.Division of Cardiology, Department of Internal Medicine, College of Medicine, Seoul St. Mary's Hospital, The Catholic University of Korea, Seoul, South Korea.Division of Cardiology, Yonsei Cardiovascular Center, Yonsei University Health System, Seoul, South Korea. hjchang@yuhs.ac. Division of Cardiology, Severance Cardiovascular Hospital, Yonsei University College of Medicine, Yonsei University Health System, 50-1 Yonsei-ro, Seodaemun-gu, Seoul, 03722, South Korea. hjchang@yuhs.ac.

Pub Type(s)

Journal Article
Multicenter Study
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

29301531

Citation

Won, Ki-Bum, et al. "Evaluation of the Impact of Glycemic Status On the Progression of Coronary Artery Calcification in Asymptomatic Individuals." Cardiovascular Diabetology, vol. 17, no. 1, 2018, p. 4.
Won KB, Han D, Lee JH, et al. Evaluation of the impact of glycemic status on the progression of coronary artery calcification in asymptomatic individuals. Cardiovasc Diabetol. 2018;17(1):4.
Won, K. B., Han, D., Lee, J. H., Lee, S. E., Sung, J. M., Choi, S. Y., Chun, E. J., Park, S. H., Han, H. W., Sung, J., Jung, H. O., & Chang, H. J. (2018). Evaluation of the impact of glycemic status on the progression of coronary artery calcification in asymptomatic individuals. Cardiovascular Diabetology, 17(1), 4. https://doi.org/10.1186/s12933-017-0653-0
Won KB, et al. Evaluation of the Impact of Glycemic Status On the Progression of Coronary Artery Calcification in Asymptomatic Individuals. Cardiovasc Diabetol. 2018 01 4;17(1):4. PubMed PMID: 29301531.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Evaluation of the impact of glycemic status on the progression of coronary artery calcification in asymptomatic individuals. AU - Won,Ki-Bum, AU - Han,Donghee, AU - Lee,Ji Hyun, AU - Lee,Sang-Eun, AU - Sung,Ji Min, AU - Choi,Su-Yeon, AU - Chun,Eun Ju, AU - Park,Sung Hak, AU - Han,Hae-Won, AU - Sung,Jidong, AU - Jung,Hae Ok, AU - Chang,Hyuk-Jae, Y1 - 2018/01/04/ PY - 2017/09/25/received PY - 2017/12/23/accepted PY - 2018/1/6/entrez PY - 2018/1/6/pubmed PY - 2019/1/29/medline KW - Coronary artery calcification KW - Diabetes KW - Pre-diabetes SP - 4 EP - 4 JF - Cardiovascular diabetology JO - Cardiovasc Diabetol VL - 17 IS - 1 N2 - BACKGROUND: Data on the influence of glycemic status on the progression of coronary calcification, an important marker for future adverse cardiovascular events, are limited. METHODS: Data from the Korea Initiatives on Coronary Artery Calcification (KOICA) registry on 12,441 asymptomatic Korean adults (52 ± 9 years, 84.2% males) without previous history of coronary artery disease and stroke, who underwent serial coronary artery calcification (CAC) screening examinations, were included in this study. The median inter-scan period was 3.0 (2.0-4.8) years. All participants were categorized into three groups based on their glycemic status: normal (n = 6578), pre-diabetes (n = 4146), and diabetes (n = 1717). CAC progression was defined as a difference ≥ 2.5 between the square roots (√) of the baseline and follow-up CAC scores. RESULTS: The incidence of CAC progression was significantly different between the three groups (normal, 26.3%; pre-diabetes, 30.9%; and diabetes, 46.9%; p < 0.001). In the univariate logistic analysis, the risk of CAC progression was higher in the pre-diabetes (odds ratio [OR] 1.253; 95% confidential interval [CI] 1.150-1.366) and diabetes (OR 2.471; 95% CI 2.215-2.758) groups than in the normal group (p < 0.001, both). In the multivariate logistic analysis, the risk of CAC progression was not significantly different between the normal and pre-diabetes groups but was significantly higher in the diabetes group than in the normal group. CONCLUSIONS: In asymptomatic subjects, diabetes had an incremental impact on CAC progression; however, pre-diabetes did not increase the risk of CAC progression after adjusting for confounding factors. SN - 1475-2840 UR - https://www.unboundmedicine.com/medline/citation/29301531/Evaluation_of_the_impact_of_glycemic_status_on_the_progression_of_coronary_artery_calcification_in_asymptomatic_individuals_ L2 - https://cardiab.biomedcentral.com/articles/10.1186/s12933-017-0653-0 DB - PRIME DP - Unbound Medicine ER -