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Screen for Inhibitors of Crystal Growth to Identify Desirable Carriers for Amorphous Solid Dispersions Containing Felodipine.
AAPS PharmSciTech. 2018 Apr; 19(3):1231-1242.AP

Abstract

The solvent-shift method was used to identify appropriate polymers that inhibit the growth of felodipine crystals by monitoring particle size in supersaturated drug solutions in the presence of different polymers. We speculated that there would be an intermolecular interaction between the selected polymer (zein) and felodipine by extrapolating the inhibitory effect on crystal growth and then used the selected polymer as a carrier to prepare solid dispersions. The formulations were characterized by crystalline properties, thermodynamics of mixing, dissolution behavior, and physical stability. Powder x-ray diffraction and differential scanning calorimetry experiments indicated that amorphous solid dispersions were formed when the proportion of felodipine was < 30% (w/w). Stability tests showed that a solid dispersion with 20% felodipine remained in an amorphous state and was stable under accelerated storage conditions for 6 months. The dissolution rates of solid dispersions were significantly greater than those of the active pharmaceutical ingredient or physical mixtures. Analysis by Fourier-transform infrared spectroscopy and Raman microspectroscopy indicated the formation of intermolecular interactions between zein and felodipine. The study demonstrates the successful application of the chosen polymer as a carrier in solid dispersions and validates the concept of extrapolating the inhibitory effect on crystal growth to intermolecular interactions.

Authors+Show Affiliations

Laboratory of Pharmaceutical Crystal Engineering & Technology, School of Pharmacy, East China University of Science and Technology, 363#, No. 130, Meilong Rd, Shanghai, 200237, China.Laboratory of Pharmaceutical Crystal Engineering & Technology, School of Pharmacy, East China University of Science and Technology, 363#, No. 130, Meilong Rd, Shanghai, 200237, China.Laboratory of Pharmaceutical Crystal Engineering & Technology, School of Pharmacy, East China University of Science and Technology, 363#, No. 130, Meilong Rd, Shanghai, 200237, China.Laboratory of Pharmaceutical Crystal Engineering & Technology, School of Pharmacy, East China University of Science and Technology, 363#, No. 130, Meilong Rd, Shanghai, 200237, China.Laboratory of Pharmaceutical Crystal Engineering & Technology, School of Pharmacy, East China University of Science and Technology, 363#, No. 130, Meilong Rd, Shanghai, 200237, China.Shanghai Key Lab New Drug Design, School of Pharmacy, East China University of Science and Technology, Shanghai, 200237, China.Laboratory of Pharmaceutical Crystal Engineering & Technology, School of Pharmacy, East China University of Science and Technology, 363#, No. 130, Meilong Rd, Shanghai, 200237, China.Laboratory of Pharmaceutical Crystal Engineering & Technology, School of Pharmacy, East China University of Science and Technology, 363#, No. 130, Meilong Rd, Shanghai, 200237, China. fzren@ecust.edu.cn.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

29302871

Citation

Fu, Jinping, et al. "Screen for Inhibitors of Crystal Growth to Identify Desirable Carriers for Amorphous Solid Dispersions Containing Felodipine." AAPS PharmSciTech, vol. 19, no. 3, 2018, pp. 1231-1242.
Fu J, Cui L, Yang C, et al. Screen for Inhibitors of Crystal Growth to Identify Desirable Carriers for Amorphous Solid Dispersions Containing Felodipine. AAPS PharmSciTech. 2018;19(3):1231-1242.
Fu, J., Cui, L., Yang, C., Xiong, H., Ren, G., Ma, X., Jing, Q., & Ren, F. (2018). Screen for Inhibitors of Crystal Growth to Identify Desirable Carriers for Amorphous Solid Dispersions Containing Felodipine. AAPS PharmSciTech, 19(3), 1231-1242. https://doi.org/10.1208/s12249-017-0942-7
Fu J, et al. Screen for Inhibitors of Crystal Growth to Identify Desirable Carriers for Amorphous Solid Dispersions Containing Felodipine. AAPS PharmSciTech. 2018;19(3):1231-1242. PubMed PMID: 29302871.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Screen for Inhibitors of Crystal Growth to Identify Desirable Carriers for Amorphous Solid Dispersions Containing Felodipine. AU - Fu,Jinping, AU - Cui,Lin, AU - Yang,Congbin, AU - Xiong,Hui, AU - Ren,Guobin, AU - Ma,Xingyuan, AU - Jing,Qiufang, AU - Ren,Fuzheng, Y1 - 2018/01/04/ PY - 2017/05/30/received PY - 2017/12/16/accepted PY - 2018/1/6/pubmed PY - 2018/7/22/medline PY - 2018/1/6/entrez KW - felodipine KW - inhibitory effect on crystal growth KW - intermolecular interactions KW - solid dispersions KW - zein SP - 1231 EP - 1242 JF - AAPS PharmSciTech JO - AAPS PharmSciTech VL - 19 IS - 3 N2 - The solvent-shift method was used to identify appropriate polymers that inhibit the growth of felodipine crystals by monitoring particle size in supersaturated drug solutions in the presence of different polymers. We speculated that there would be an intermolecular interaction between the selected polymer (zein) and felodipine by extrapolating the inhibitory effect on crystal growth and then used the selected polymer as a carrier to prepare solid dispersions. The formulations were characterized by crystalline properties, thermodynamics of mixing, dissolution behavior, and physical stability. Powder x-ray diffraction and differential scanning calorimetry experiments indicated that amorphous solid dispersions were formed when the proportion of felodipine was < 30% (w/w). Stability tests showed that a solid dispersion with 20% felodipine remained in an amorphous state and was stable under accelerated storage conditions for 6 months. The dissolution rates of solid dispersions were significantly greater than those of the active pharmaceutical ingredient or physical mixtures. Analysis by Fourier-transform infrared spectroscopy and Raman microspectroscopy indicated the formation of intermolecular interactions between zein and felodipine. The study demonstrates the successful application of the chosen polymer as a carrier in solid dispersions and validates the concept of extrapolating the inhibitory effect on crystal growth to intermolecular interactions. SN - 1530-9932 UR - https://www.unboundmedicine.com/medline/citation/29302871/Screen_for_Inhibitors_of_Crystal_Growth_to_Identify_Desirable_Carriers_for_Amorphous_Solid_Dispersions_Containing_Felodipine_ L2 - https://dx.doi.org/10.1208/s12249-017-0942-7 DB - PRIME DP - Unbound Medicine ER -