Tags

Type your tag names separated by a space and hit enter

Steroid hormone levels in serum and skin receptor concentrations in hirsutism.
Endocrinol Exp. 1985 Sep; 19(3):147-55.EE

Abstract

In 36 women androgen (AR), estrogen (ER) and progesterone (PgR) receptor were determined by dextran coated charcoal assay and subsequent Scatchard plot analysis in skin slices obtained from hirsute areas under local anesthesia. The biopsies were performed between day 18-21 of the menstrual cycle. Concomitantly venous blood was sampled in these and additional 14 patients for radioimmunoassay estimation of serum levels of testosterone (T), dehydroepiandrosterone sulfate (DHEA-S), androstenedione (A), estradiol (E2) and prolactin (PRL). However, it should be noted that all receptors and hormones were not examined in all patients. The incidence of ER-positive patients was smaller (i.e. 17%) than previous findings in acne and normal skin, while 26% of the examined patients were AR-positive. This result was similar to findings in acne, whereas the receptor levels are three times higher than in acne lesions. This suggests a greater androgen sensitivity of hirsute areas compared to acne lesions. Two out of 10 examined patients were PgR-positive. T was elevated in 63%, DHEA-S in 50% and A in 37% of examined patients. Lack of correlation between hormone serum levels and corresponding receptors concentration indicates a direct involvement of hormone action at the cellular level. The data combine to suggest that greater target organ sensitivity was responsible for hirsutism in those patients with normal androgen serum levels, while the absence of receptors in skin samples may characterize patients with idiopathic hirsutism.

Authors

No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

2931274

Citation

Schmidt, J B., et al. "Steroid Hormone Levels in Serum and Skin Receptor Concentrations in Hirsutism." Endocrinologia Experimentalis, vol. 19, no. 3, 1985, pp. 147-55.
Schmidt JB, Huber J, Spona J. Steroid hormone levels in serum and skin receptor concentrations in hirsutism. Endocrinol Exp. 1985;19(3):147-55.
Schmidt, J. B., Huber, J., & Spona, J. (1985). Steroid hormone levels in serum and skin receptor concentrations in hirsutism. Endocrinologia Experimentalis, 19(3), 147-55.
Schmidt JB, Huber J, Spona J. Steroid Hormone Levels in Serum and Skin Receptor Concentrations in Hirsutism. Endocrinol Exp. 1985;19(3):147-55. PubMed PMID: 2931274.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Steroid hormone levels in serum and skin receptor concentrations in hirsutism. AU - Schmidt,J B, AU - Huber,J, AU - Spona,J, PY - 1985/9/1/pubmed PY - 1985/9/1/medline PY - 1985/9/1/entrez SP - 147 EP - 55 JF - Endocrinologia experimentalis JO - Endocrinol. Exp. VL - 19 IS - 3 N2 - In 36 women androgen (AR), estrogen (ER) and progesterone (PgR) receptor were determined by dextran coated charcoal assay and subsequent Scatchard plot analysis in skin slices obtained from hirsute areas under local anesthesia. The biopsies were performed between day 18-21 of the menstrual cycle. Concomitantly venous blood was sampled in these and additional 14 patients for radioimmunoassay estimation of serum levels of testosterone (T), dehydroepiandrosterone sulfate (DHEA-S), androstenedione (A), estradiol (E2) and prolactin (PRL). However, it should be noted that all receptors and hormones were not examined in all patients. The incidence of ER-positive patients was smaller (i.e. 17%) than previous findings in acne and normal skin, while 26% of the examined patients were AR-positive. This result was similar to findings in acne, whereas the receptor levels are three times higher than in acne lesions. This suggests a greater androgen sensitivity of hirsute areas compared to acne lesions. Two out of 10 examined patients were PgR-positive. T was elevated in 63%, DHEA-S in 50% and A in 37% of examined patients. Lack of correlation between hormone serum levels and corresponding receptors concentration indicates a direct involvement of hormone action at the cellular level. The data combine to suggest that greater target organ sensitivity was responsible for hirsutism in those patients with normal androgen serum levels, while the absence of receptors in skin samples may characterize patients with idiopathic hirsutism. SN - 0013-7200 UR - https://www.unboundmedicine.com/medline/citation/2931274/Steroid_hormone_levels_in_serum_and_skin_receptor_concentrations_in_hirsutism_ DB - PRIME DP - Unbound Medicine ER -