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Management of Statin Intolerance in 2018: Still More Questions Than Answers.
Am J Cardiovasc Drugs. 2018 Jun; 18(3):157-173.AJ

Abstract

Statin therapy is generally well tolerated and very effective in the prevention and treatment of cardiovascular disease, regardless of cholesterol levels; however, it can be associated with various adverse events (myalgia, myopathy, rhabdomyolysis, and diabetes mellitus, among others). Patients frequently discontinue statin therapy without medical advice because of perceived side effects and consequently increase their risk for cardiovascular events. In patients with statin intolerance, it may be advisable to change the dose, switch to a different statin, or try an alternate-day regimen. If intolerance is associated with all statins-even at the lowest dose-non-statin drugs and certain nutraceuticals can be considered. This review focuses on the definition of statin intolerance and on the development of clinical and therapeutic strategies for its management, including emerging alternative therapies.

Authors+Show Affiliations

CGH Medical Center, Sterling, IL, USA. Ciccarone Center for the Prevention of Cardiovascular Disease, Johns Hopkins University School of Medicine, Baltimore, MD, USA.Biomedical Department of Internal Medicine and Medical Specialties, University of Palermo, Palermo, Italy.Biomedical Department of Internal Medicine and Medical Specialties, University of Palermo, Palermo, Italy.Biomedical Department of Internal Medicine and Medical Specialties, University of Palermo, Palermo, Italy.Biomedical Department of Internal Medicine and Medical Specialties, University of Palermo, Palermo, Italy.Biomedical Department of Internal Medicine and Medical Specialties, University of Palermo, Palermo, Italy.Chair of Nephrology and Hypertension, Department of Hypertension, WAM University Hospital in Lodz, Medical University of Lodz, Zeromskiego 113, 90-549, Lodz, Poland. maciejbanach77@gmail.com. Polish Mother's Memorial Hospital Research Institute, Lodz, Poland. maciejbanach77@gmail.com. Cardiovascular Research Centre, University of Zielona Gora, Zielona Gora, Poland. maciejbanach77@gmail.com.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

29318532

Citation

Toth, Peter P., et al. "Management of Statin Intolerance in 2018: Still More Questions Than Answers." American Journal of Cardiovascular Drugs : Drugs, Devices, and Other Interventions, vol. 18, no. 3, 2018, pp. 157-173.
Toth PP, Patti AM, Giglio RV, et al. Management of Statin Intolerance in 2018: Still More Questions Than Answers. Am J Cardiovasc Drugs. 2018;18(3):157-173.
Toth, P. P., Patti, A. M., Giglio, R. V., Nikolic, D., Castellino, G., Rizzo, M., & Banach, M. (2018). Management of Statin Intolerance in 2018: Still More Questions Than Answers. American Journal of Cardiovascular Drugs : Drugs, Devices, and Other Interventions, 18(3), 157-173. https://doi.org/10.1007/s40256-017-0259-7
Toth PP, et al. Management of Statin Intolerance in 2018: Still More Questions Than Answers. Am J Cardiovasc Drugs. 2018;18(3):157-173. PubMed PMID: 29318532.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Management of Statin Intolerance in 2018: Still More Questions Than Answers. AU - Toth,Peter P, AU - Patti,Angelo Maria, AU - Giglio,Rosaria Vincenza, AU - Nikolic,Dragana, AU - Castellino,Giuseppa, AU - Rizzo,Manfredi, AU - Banach,Maciej, PY - 2018/1/11/pubmed PY - 2018/9/27/medline PY - 2018/1/11/entrez SP - 157 EP - 173 JF - American journal of cardiovascular drugs : drugs, devices, and other interventions JO - Am J Cardiovasc Drugs VL - 18 IS - 3 N2 - Statin therapy is generally well tolerated and very effective in the prevention and treatment of cardiovascular disease, regardless of cholesterol levels; however, it can be associated with various adverse events (myalgia, myopathy, rhabdomyolysis, and diabetes mellitus, among others). Patients frequently discontinue statin therapy without medical advice because of perceived side effects and consequently increase their risk for cardiovascular events. In patients with statin intolerance, it may be advisable to change the dose, switch to a different statin, or try an alternate-day regimen. If intolerance is associated with all statins-even at the lowest dose-non-statin drugs and certain nutraceuticals can be considered. This review focuses on the definition of statin intolerance and on the development of clinical and therapeutic strategies for its management, including emerging alternative therapies. SN - 1179-187X UR - https://www.unboundmedicine.com/medline/citation/29318532/Management_of_Statin_Intolerance_in_2018:_Still_More_Questions_Than_Answers_ L2 - https://dx.doi.org/10.1007/s40256-017-0259-7 DB - PRIME DP - Unbound Medicine ER -