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A Perfect sTORm: The Role of the Mammalian Target of Rapamycin (mTOR) in Cerebrovascular Dysfunction of Alzheimer's Disease: A Mini-Review.
Gerontology 2018; 64(3):205-211G

Abstract

Cerebrovascular dysfunction is detected prior to the onset of cognitive and histopathological changes in Alzheimer's disease (AD). Increasing evidence indicates a critical role of cerebrovascular dysfunction in the initiation and progression of AD. Recent studies identified the mechanistic/mammalian target of rapamycin (mTOR) as a critical effector of cerebrovascular dysfunction in AD. mTOR has a key role in the regulation of metabolism, but some mTOR-dependent mechanisms are uniquely specific to the regulation of cerebrovascular function. These include the regulation of cerebral blood flow, blood-brain barrier integrity and maintenance, neurovascular coupling, and cerebrovascular reactivity. This article examines the available evidence for a role of mTOR-driven cerebrovascular dysfunction in the pathogenesis of AD and of vascular cognitive impairment and dementia (VCID) and highlights the therapeutic potential of targeting mTOR and/or specific downstream effectors for vasculoprotection in AD, VCID, and other age-associated neurological diseases with cerebrovascular etiology.

Authors+Show Affiliations

Department of Cellular and Integrative Physiology and The Barshop Institute for Longevity and Aging Studies, University of Texas Health San Antonio, San Antonio, TX, USA.No affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Review

Language

eng

PubMed ID

29320772

Citation

Van Skike, Candice E., and Veronica Galvan. "A Perfect sTORm: the Role of the Mammalian Target of Rapamycin (mTOR) in Cerebrovascular Dysfunction of Alzheimer's Disease: a Mini-Review." Gerontology, vol. 64, no. 3, 2018, pp. 205-211.
Van Skike CE, Galvan V. A Perfect sTORm: The Role of the Mammalian Target of Rapamycin (mTOR) in Cerebrovascular Dysfunction of Alzheimer's Disease: A Mini-Review. Gerontology. 2018;64(3):205-211.
Van Skike, C. E., & Galvan, V. (2018). A Perfect sTORm: The Role of the Mammalian Target of Rapamycin (mTOR) in Cerebrovascular Dysfunction of Alzheimer's Disease: A Mini-Review. Gerontology, 64(3), pp. 205-211. doi:10.1159/000485381.
Van Skike CE, Galvan V. A Perfect sTORm: the Role of the Mammalian Target of Rapamycin (mTOR) in Cerebrovascular Dysfunction of Alzheimer's Disease: a Mini-Review. Gerontology. 2018;64(3):205-211. PubMed PMID: 29320772.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A Perfect sTORm: The Role of the Mammalian Target of Rapamycin (mTOR) in Cerebrovascular Dysfunction of Alzheimer's Disease: A Mini-Review. AU - Van Skike,Candice E, AU - Galvan,Veronica, Y1 - 2018/01/11/ PY - 2017/09/06/received PY - 2017/11/16/accepted PY - 2018/1/11/pubmed PY - 2018/11/27/medline PY - 2018/1/11/entrez KW - Alzheimer’s disease KW - Blood-brain barrier KW - Cerebral blood flow KW - Neurovascular coupling KW - Rapamycin KW - Vascular density KW - mTOR SP - 205 EP - 211 JF - Gerontology JO - Gerontology VL - 64 IS - 3 N2 - Cerebrovascular dysfunction is detected prior to the onset of cognitive and histopathological changes in Alzheimer's disease (AD). Increasing evidence indicates a critical role of cerebrovascular dysfunction in the initiation and progression of AD. Recent studies identified the mechanistic/mammalian target of rapamycin (mTOR) as a critical effector of cerebrovascular dysfunction in AD. mTOR has a key role in the regulation of metabolism, but some mTOR-dependent mechanisms are uniquely specific to the regulation of cerebrovascular function. These include the regulation of cerebral blood flow, blood-brain barrier integrity and maintenance, neurovascular coupling, and cerebrovascular reactivity. This article examines the available evidence for a role of mTOR-driven cerebrovascular dysfunction in the pathogenesis of AD and of vascular cognitive impairment and dementia (VCID) and highlights the therapeutic potential of targeting mTOR and/or specific downstream effectors for vasculoprotection in AD, VCID, and other age-associated neurological diseases with cerebrovascular etiology. SN - 1423-0003 UR - https://www.unboundmedicine.com/medline/citation/29320772/A_Perfect_sTORm:_The_Role_of_the_Mammalian_Target_of_Rapamycin__mTOR__in_Cerebrovascular_Dysfunction_of_Alzheimer's_Disease:_A_Mini_Review_ L2 - https://www.karger.com?DOI=10.1159/000485381 DB - PRIME DP - Unbound Medicine ER -