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Plasminogen activator inhibitor-1: a risk factor for deep vein thrombosis after total hip arthroplasty.
J Orthop Surg Res. 2018 Jan 10; 13(1):8.JO

Abstract

BACKGROUND

The onset of deep vein thrombosis (DVT) in patients after total hip arthroplasty (THA) may expand or enlarge and subsequently lead to significant mortality. The objective of this study was to investigate potential risk factors for DVT in patients after THA.

METHODS

Eligible patients with hip joint diseases who were scheduled for unilateral primary THA at our hospital were prospectively included into this study. The demographic and clinical features, preoperative plasma biomarkers were detailed, recorded, and compared. The multiple logistic regression analysis was used to evaluate potential risk factors for DVT.

RESULTS

A total of 214 subjects were enrolled into our study cohort for the final analysis, and 23 of them have suffered DVT with an incidence of 9.5%. The performance of logistic regression analysis showed that preoperative expression of plasminogen activator inhibitor-1 (PAI-1) was an independent risk factor for the onset of DVT in patients after THA (OR 1.18, 95% CI 1.04-1.29; p = 0.011).

CONCLUSIONS

Our study indicated preoperative plasma PAI-1 expression as an independent risk factor for DVT in patients who underwent THA.

Authors+Show Affiliations

Department of Joint Surgery, Taizhou People's Hospital, Medical School of Nantong University, No. 210 Yingchun Road, Taizhou City, Jiangsu Province,, 225300, China.Department of Joint Surgery, Taizhou People's Hospital, Medical School of Nantong University, No. 210 Yingchun Road, Taizhou City, Jiangsu Province,, 225300, China.Department of Joint Surgery, Taizhou People's Hospital, Medical School of Nantong University, No. 210 Yingchun Road, Taizhou City, Jiangsu Province,, 225300, China.Department of Joint Surgery, Taizhou People's Hospital, Medical School of Nantong University, No. 210 Yingchun Road, Taizhou City, Jiangsu Province,, 225300, China. zhangzhenxiangtz@sina.com.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

29321050

Citation

Tang, Ju, et al. "Plasminogen Activator Inhibitor-1: a Risk Factor for Deep Vein Thrombosis After Total Hip Arthroplasty." Journal of Orthopaedic Surgery and Research, vol. 13, no. 1, 2018, p. 8.
Tang J, Zhu W, Mei X, et al. Plasminogen activator inhibitor-1: a risk factor for deep vein thrombosis after total hip arthroplasty. J Orthop Surg Res. 2018;13(1):8.
Tang, J., Zhu, W., Mei, X., & Zhang, Z. (2018). Plasminogen activator inhibitor-1: a risk factor for deep vein thrombosis after total hip arthroplasty. Journal of Orthopaedic Surgery and Research, 13(1), 8. https://doi.org/10.1186/s13018-018-0716-2
Tang J, et al. Plasminogen Activator Inhibitor-1: a Risk Factor for Deep Vein Thrombosis After Total Hip Arthroplasty. J Orthop Surg Res. 2018 Jan 10;13(1):8. PubMed PMID: 29321050.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Plasminogen activator inhibitor-1: a risk factor for deep vein thrombosis after total hip arthroplasty. AU - Tang,Ju, AU - Zhu,Wei, AU - Mei,Xiaoliang, AU - Zhang,Zhenxiang, Y1 - 2018/01/10/ PY - 2017/10/15/received PY - 2018/01/02/accepted PY - 2018/1/12/entrez PY - 2018/1/13/pubmed PY - 2018/8/7/medline KW - Deep vein thrombosis KW - Plasminogen activator inhibitor-1 KW - Risk factor KW - Total hip arthroplasty SP - 8 EP - 8 JF - Journal of orthopaedic surgery and research JO - J Orthop Surg Res VL - 13 IS - 1 N2 - BACKGROUND: The onset of deep vein thrombosis (DVT) in patients after total hip arthroplasty (THA) may expand or enlarge and subsequently lead to significant mortality. The objective of this study was to investigate potential risk factors for DVT in patients after THA. METHODS: Eligible patients with hip joint diseases who were scheduled for unilateral primary THA at our hospital were prospectively included into this study. The demographic and clinical features, preoperative plasma biomarkers were detailed, recorded, and compared. The multiple logistic regression analysis was used to evaluate potential risk factors for DVT. RESULTS: A total of 214 subjects were enrolled into our study cohort for the final analysis, and 23 of them have suffered DVT with an incidence of 9.5%. The performance of logistic regression analysis showed that preoperative expression of plasminogen activator inhibitor-1 (PAI-1) was an independent risk factor for the onset of DVT in patients after THA (OR 1.18, 95% CI 1.04-1.29; p = 0.011). CONCLUSIONS: Our study indicated preoperative plasma PAI-1 expression as an independent risk factor for DVT in patients who underwent THA. SN - 1749-799X UR - https://www.unboundmedicine.com/medline/citation/29321050/Plasminogen_activator_inhibitor_1:_a_risk_factor_for_deep_vein_thrombosis_after_total_hip_arthroplasty_ L2 - https://josr-online.biomedcentral.com/articles/10.1186/s13018-018-0716-2 DB - PRIME DP - Unbound Medicine ER -