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CV2/CRMP5-antibody-related Paraneoplastic Optic Neuropathy Associated with Small-cell Lung Cancer.
Intern Med. 2018 Jun 01; 57(11):1645-1649.IM

Abstract

A 61-year-old woman who had smoked for 41 years developed subacute dizziness, ataxic gait, opsoclonus, and right visual impairment. She had right optic disc swelling and optic nerve gadolinium enhancement on magnetic resonance imaging. She had small-cell lung cancer (SCLC), with CV2/collapsin response mediator protein (CRMP) 5 and HuD antibodies in her serum and cerebrospinal fluid. She was diagnosed with paraneoplastic optic neuropathy (PON) accompanied by paraneoplastic opsoclonus-ataxia syndrome. Her symptoms improved after removing the SCLC. Classical PON is rare in Japan. We recommend assaying for CV2/CRMP5 antibodies and searching for cancer in elderly patients with subacute painless visual impairment.

Authors+Show Affiliations

Department of Neurology, Faculty of Medicine, Kyorin University, Japan.Department of Neurology, Faculty of Medicine, Kyorin University, Japan.Department of Neurology, Faculty of Medicine, Kyorin University, Japan.Department of Neurology, Faculty of Medicine, Kyorin University, Japan.Department of Neurology, Faculty of Medicine, Kyorin University, Japan.Department of Neurology, Tohoku University Graduate School of Medicine, Japan.Department of Neurology, National Hospital Organization, Yonezawa Hospital, Japan.Department of Neurology, Tohoku Medical and Pharmaceutical University, Japan.Department of Neurology and Strokology, Nagasaki University Hospital, Japan.Medical Engineering Course, Department of Engineering, Faculty of Engineering, Nagasaki Institute of Applied Science, Japan.Department of Neurology, Faculty of Medicine, Kyorin University, Japan.

Pub Type(s)

Case Reports
Journal Article

Language

eng

PubMed ID

29321433

Citation

Nakajima, Masanori, et al. "CV2/CRMP5-antibody-related Paraneoplastic Optic Neuropathy Associated With Small-cell Lung Cancer." Internal Medicine (Tokyo, Japan), vol. 57, no. 11, 2018, pp. 1645-1649.
Nakajima M, Uchibori A, Ogawa Y, et al. CV2/CRMP5-antibody-related Paraneoplastic Optic Neuropathy Associated with Small-cell Lung Cancer. Intern Med. 2018;57(11):1645-1649.
Nakajima, M., Uchibori, A., Ogawa, Y., Miyazaki, T., Ichikawa, Y., Kaneko, K., Takahashi, T., Nakashima, I., Shiraishi, H., Motomura, M., & Chiba, A. (2018). CV2/CRMP5-antibody-related Paraneoplastic Optic Neuropathy Associated with Small-cell Lung Cancer. Internal Medicine (Tokyo, Japan), 57(11), 1645-1649. https://doi.org/10.2169/internalmedicine.9736-17
Nakajima M, et al. CV2/CRMP5-antibody-related Paraneoplastic Optic Neuropathy Associated With Small-cell Lung Cancer. Intern Med. 2018 Jun 1;57(11):1645-1649. PubMed PMID: 29321433.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - CV2/CRMP5-antibody-related Paraneoplastic Optic Neuropathy Associated with Small-cell Lung Cancer. AU - Nakajima,Masanori, AU - Uchibori,Ayumi, AU - Ogawa,Yuki, AU - Miyazaki,Tai, AU - Ichikawa,Yaeko, AU - Kaneko,Kimihiko, AU - Takahashi,Toshiyuki, AU - Nakashima,Ichiro, AU - Shiraishi,Hirokazu, AU - Motomura,Masakatsu, AU - Chiba,Atsuro, Y1 - 2018/01/11/ PY - 2018/1/13/pubmed PY - 2018/10/18/medline PY - 2018/1/12/entrez KW - CV2/CRMP5 antibodies KW - HuD antibodies KW - paraneoplastic opsoclonus-ataxia syndrome KW - paraneoplastic optic neuropathy KW - small-cell lung cancer SP - 1645 EP - 1649 JF - Internal medicine (Tokyo, Japan) JO - Intern. Med. VL - 57 IS - 11 N2 - A 61-year-old woman who had smoked for 41 years developed subacute dizziness, ataxic gait, opsoclonus, and right visual impairment. She had right optic disc swelling and optic nerve gadolinium enhancement on magnetic resonance imaging. She had small-cell lung cancer (SCLC), with CV2/collapsin response mediator protein (CRMP) 5 and HuD antibodies in her serum and cerebrospinal fluid. She was diagnosed with paraneoplastic optic neuropathy (PON) accompanied by paraneoplastic opsoclonus-ataxia syndrome. Her symptoms improved after removing the SCLC. Classical PON is rare in Japan. We recommend assaying for CV2/CRMP5 antibodies and searching for cancer in elderly patients with subacute painless visual impairment. SN - 1349-7235 UR - https://www.unboundmedicine.com/medline/citation/29321433/CV2/CRMP5_antibody_related_Paraneoplastic_Optic_Neuropathy_Associated_with_Small_cell_Lung_Cancer_ L2 - https://dx.doi.org/10.2169/internalmedicine.9736-17 DB - PRIME DP - Unbound Medicine ER -