Tags

Type your tag names separated by a space and hit enter

Effects of short-term DHEA intake on hormonal responses in young recreationally trained athletes: modulation by gender.
Endocrine. 2018 03; 59(3):538-546.E

Abstract

BACKGROUND

Dehydroepiandrosterone (DHEA) figures on the World Anti-Doping Agency list of prohibited substances in sport because it is assumed that athletes expect a significant increase in testosterone through DHEA administration. The literature on the hormonal effects of DHEA intake nevertheless appears to be very scant in healthy young subjects, especially women.

PURPOSE

We examined the effects of DHEA on adrenal and gonadal hormones, IGF1 and free T3 in healthy young male and female recreationally trained volunteers.

METHODS

The study followed a double-blind, randomized-order crossover design. Lean healthy young men (n = 10) and women (n = 11), with all women using oral contraceptives, were treated daily with 100 mg of DHEA and placebo for 4 weeks. DHEA, DHEA-sulfate (DHEA-S), androstenedione, total testosterone (Tes), dihydrotestosterone (DHT), SHBG, estrone, cortisol, IGF1, and free T3 were measured before, in the middle and at the end of each treatment, as were blood glucose, liver transaminases and lipid status.

RESULTS

We observed a significant increase in DHEA, DHEA-S, androstenedione, Tes, DHT, and estrone in both men and women in the middle and at the end of DHEA treatment, but the increase in Tes was more marked in women (p < 0.001) than men (p < 0.05). No changes were found in the other parameters, irrespective of gender.

CONCLUSION

In young athletes, DHEA administration induces significant blood hormonal changes, some modulated by gender, which can be used as biomarkers of doping.

Authors+Show Affiliations

CIAMS, Univ. Paris-Sud, Université Paris-Saclay, Orsay, France. katia.collomp@univ-orleans.fr. CIAMS, Université Orléans, Orléans, France. katia.collomp@univ-orleans.fr. Département des Analyses, AFLD, Chatenay-Malabry, France. katia.collomp@univ-orleans.fr.Département des Analyses, AFLD, Chatenay-Malabry, France.CIAMS, Univ. Paris-Sud, Université Paris-Saclay, Orsay, France. CIAMS, Université Orléans, Orléans, France.Service de Médecine Préventive, Univ. Paris-Sud, Université Paris-Saclay, Orsay, France.CIAMS, Univ. Paris-Sud, Université Paris-Saclay, Orsay, France. CIAMS, Université Orléans, Orléans, France.CIAMS, Univ. Paris-Sud, Université Paris-Saclay, Orsay, France. CIAMS, Université Orléans, Orléans, France.CIAMS, Univ. Paris-Sud, Université Paris-Saclay, Orsay, France. CIAMS, Université Orléans, Orléans, France.Laboratoire de Développement Analytique, AGEPS, Paris, France.CIAMS, Univ. Paris-Sud, Université Paris-Saclay, Orsay, France. CIAMS, Université Orléans, Orléans, France.Département des Analyses, AFLD, Chatenay-Malabry, France.

Pub Type(s)

Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

29322301

Citation

Collomp, Katia, et al. "Effects of Short-term DHEA Intake On Hormonal Responses in Young Recreationally Trained Athletes: Modulation By Gender." Endocrine, vol. 59, no. 3, 2018, pp. 538-546.
Collomp K, Buisson C, Gravisse N, et al. Effects of short-term DHEA intake on hormonal responses in young recreationally trained athletes: modulation by gender. Endocrine. 2018;59(3):538-546.
Collomp, K., Buisson, C., Gravisse, N., Belgherbi, S., Labsy, Z., Do, M. C., Gagey, O., Dufay, S., Vibarel-Rebot, N., & Audran, M. (2018). Effects of short-term DHEA intake on hormonal responses in young recreationally trained athletes: modulation by gender. Endocrine, 59(3), 538-546. https://doi.org/10.1007/s12020-017-1514-z
Collomp K, et al. Effects of Short-term DHEA Intake On Hormonal Responses in Young Recreationally Trained Athletes: Modulation By Gender. Endocrine. 2018;59(3):538-546. PubMed PMID: 29322301.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of short-term DHEA intake on hormonal responses in young recreationally trained athletes: modulation by gender. AU - Collomp,Katia, AU - Buisson,Corinne, AU - Gravisse,Nicolas, AU - Belgherbi,Soraya, AU - Labsy,Zakaria, AU - Do,Manh-Cuong, AU - Gagey,Olivier, AU - Dufay,Sophie, AU - Vibarel-Rebot,Nancy, AU - Audran,Michel, Y1 - 2018/01/10/ PY - 2017/10/04/received PY - 2017/12/26/accepted PY - 2018/1/13/pubmed PY - 2018/10/27/medline PY - 2018/1/12/entrez KW - Androstenedione KW - DHEA administration KW - DHT KW - Testosterone KW - Young females KW - Young males SP - 538 EP - 546 JF - Endocrine JO - Endocrine VL - 59 IS - 3 N2 - BACKGROUND: Dehydroepiandrosterone (DHEA) figures on the World Anti-Doping Agency list of prohibited substances in sport because it is assumed that athletes expect a significant increase in testosterone through DHEA administration. The literature on the hormonal effects of DHEA intake nevertheless appears to be very scant in healthy young subjects, especially women. PURPOSE: We examined the effects of DHEA on adrenal and gonadal hormones, IGF1 and free T3 in healthy young male and female recreationally trained volunteers. METHODS: The study followed a double-blind, randomized-order crossover design. Lean healthy young men (n = 10) and women (n = 11), with all women using oral contraceptives, were treated daily with 100 mg of DHEA and placebo for 4 weeks. DHEA, DHEA-sulfate (DHEA-S), androstenedione, total testosterone (Tes), dihydrotestosterone (DHT), SHBG, estrone, cortisol, IGF1, and free T3 were measured before, in the middle and at the end of each treatment, as were blood glucose, liver transaminases and lipid status. RESULTS: We observed a significant increase in DHEA, DHEA-S, androstenedione, Tes, DHT, and estrone in both men and women in the middle and at the end of DHEA treatment, but the increase in Tes was more marked in women (p < 0.001) than men (p < 0.05). No changes were found in the other parameters, irrespective of gender. CONCLUSION: In young athletes, DHEA administration induces significant blood hormonal changes, some modulated by gender, which can be used as biomarkers of doping. SN - 1559-0100 UR - https://www.unboundmedicine.com/medline/citation/29322301/Effects_of_short_term_DHEA_intake_on_hormonal_responses_in_young_recreationally_trained_athletes:_modulation_by_gender_ L2 - https://dx.doi.org/10.1007/s12020-017-1514-z DB - PRIME DP - Unbound Medicine ER -