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The Pivotal Role of Copper in Neurodegeneration: A New Strategy for the Therapy of Neurodegenerative Disorders.
Mol Pharm. 2018 03 05; 15(3):808-820.MP

Abstract

Copper is an essential trace element for the human body since it is a cofactor of several enzymes and proteins and plays a pivotal role in several biological functions (e.g., respiration, protection from oxidative damage, iron metabolism, etc.), also including the central nervous system development and functioning (e.g., synthesis of neurotransmitters, myelination, activation of neuropeptides, etc.). Therefore, copper dysmetabolism is associated with different toxic effects, mainly represented by oxidative stress, and it has been reported in many neurodegenerative disorders, such as Wilson's disease, Menkes disease, Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis. This paper shows a detailed report of how copper is involved in the pathophysiology of these diseases. Moreover, a hint on novel therapeutic approaches based on restoring copper homeostasis through metal chelators will be pointed out.

Authors+Show Affiliations

Dipartimento di Farmacia-Scienze del Farmaco , Università degli Studi di Bari Aldo Moro , Via Orabona 4 , 70125 , Bari , Italy.Dipartimento di Farmacia-Scienze del Farmaco , Università degli Studi di Bari Aldo Moro , Via Orabona 4 , 70125 , Bari , Italy.Dipartimento di Farmacia-Scienze del Farmaco , Università degli Studi di Bari Aldo Moro , Via Orabona 4 , 70125 , Bari , Italy.Dipartimento di Farmacia-Scienze del Farmaco , Università degli Studi di Bari Aldo Moro , Via Orabona 4 , 70125 , Bari , Italy. Biofordrug srl, Dipartimento di Farmacia-Scienze del Farmaco , Università degli Studi di Bari Aldo Moro , Via Orabona 4 , 70125 , Bari , Italy.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

29323501

Citation

Giampietro, Roberta, et al. "The Pivotal Role of Copper in Neurodegeneration: a New Strategy for the Therapy of Neurodegenerative Disorders." Molecular Pharmaceutics, vol. 15, no. 3, 2018, pp. 808-820.
Giampietro R, Spinelli F, Contino M, et al. The Pivotal Role of Copper in Neurodegeneration: A New Strategy for the Therapy of Neurodegenerative Disorders. Mol Pharm. 2018;15(3):808-820.
Giampietro, R., Spinelli, F., Contino, M., & Colabufo, N. A. (2018). The Pivotal Role of Copper in Neurodegeneration: A New Strategy for the Therapy of Neurodegenerative Disorders. Molecular Pharmaceutics, 15(3), 808-820. https://doi.org/10.1021/acs.molpharmaceut.7b00841
Giampietro R, et al. The Pivotal Role of Copper in Neurodegeneration: a New Strategy for the Therapy of Neurodegenerative Disorders. Mol Pharm. 2018 03 5;15(3):808-820. PubMed PMID: 29323501.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The Pivotal Role of Copper in Neurodegeneration: A New Strategy for the Therapy of Neurodegenerative Disorders. AU - Giampietro,Roberta, AU - Spinelli,Francesco, AU - Contino,Marialessandra, AU - Colabufo,Nicola Antonio, Y1 - 2018/02/02/ PY - 2018/1/13/pubmed PY - 2019/4/6/medline PY - 2018/1/12/entrez KW - copper KW - metal chelators KW - natural compounds KW - neurodegenerative diseases KW - oxidative stress SP - 808 EP - 820 JF - Molecular pharmaceutics JO - Mol. Pharm. VL - 15 IS - 3 N2 - Copper is an essential trace element for the human body since it is a cofactor of several enzymes and proteins and plays a pivotal role in several biological functions (e.g., respiration, protection from oxidative damage, iron metabolism, etc.), also including the central nervous system development and functioning (e.g., synthesis of neurotransmitters, myelination, activation of neuropeptides, etc.). Therefore, copper dysmetabolism is associated with different toxic effects, mainly represented by oxidative stress, and it has been reported in many neurodegenerative disorders, such as Wilson's disease, Menkes disease, Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis. This paper shows a detailed report of how copper is involved in the pathophysiology of these diseases. Moreover, a hint on novel therapeutic approaches based on restoring copper homeostasis through metal chelators will be pointed out. SN - 1543-8392 UR - https://www.unboundmedicine.com/medline/citation/29323501/The_Pivotal_Role_of_Copper_in_Neurodegeneration:_A_New_Strategy_for_the_Therapy_of_Neurodegenerative_Disorders_ L2 - https://dx.doi.org/10.1021/acs.molpharmaceut.7b00841 DB - PRIME DP - Unbound Medicine ER -