Citation
Arts, Rob J W., et al. "BCG Vaccination Protects Against Experimental Viral Infection in Humans Through the Induction of Cytokines Associated With Trained Immunity." Cell Host & Microbe, vol. 23, no. 1, 2018, pp. 89-100.e5.
Arts RJW, Moorlag SJCFM, Novakovic B, et al. BCG Vaccination Protects against Experimental Viral Infection in Humans through the Induction of Cytokines Associated with Trained Immunity. Cell Host Microbe. 2018;23(1):89-100.e5.
Arts, R. J. W., Moorlag, S. J. C. F. M., Novakovic, B., Li, Y., Wang, S. Y., Oosting, M., Kumar, V., Xavier, R. J., Wijmenga, C., Joosten, L. A. B., Reusken, C. B. E. M., Benn, C. S., Aaby, P., Koopmans, M. P., Stunnenberg, H. G., van Crevel, R., & Netea, M. G. (2018). BCG Vaccination Protects against Experimental Viral Infection in Humans through the Induction of Cytokines Associated with Trained Immunity. Cell Host & Microbe, 23(1), 89-e5. https://doi.org/10.1016/j.chom.2017.12.010
Arts RJW, et al. BCG Vaccination Protects Against Experimental Viral Infection in Humans Through the Induction of Cytokines Associated With Trained Immunity. Cell Host Microbe. 2018 Jan 10;23(1):89-100.e5. PubMed PMID: 29324233.
TY - JOUR
T1 - BCG Vaccination Protects against Experimental Viral Infection in Humans through the Induction of Cytokines Associated with Trained Immunity.
AU - Arts,Rob J W,
AU - Moorlag,Simone J C F M,
AU - Novakovic,Boris,
AU - Li,Yang,
AU - Wang,Shuang-Yin,
AU - Oosting,Marije,
AU - Kumar,Vinod,
AU - Xavier,Ramnik J,
AU - Wijmenga,Cisca,
AU - Joosten,Leo A B,
AU - Reusken,Chantal B E M,
AU - Benn,Christine S,
AU - Aaby,Peter,
AU - Koopmans,Marion P,
AU - Stunnenberg,Hendrik G,
AU - van Crevel,Reinout,
AU - Netea,Mihai G,
PY - 2017/04/18/received
PY - 2017/09/25/revised
PY - 2017/12/19/accepted
PY - 2018/1/12/entrez
PY - 2018/1/13/pubmed
PY - 2018/8/17/medline
KW - BCG
KW - IL-1
KW - epigenetics
KW - innate immune memory
KW - monocytes
KW - non-specific effects of vaccines
KW - trained immunity
KW - yellow fever vaccine
SP - 89
EP - 100.e5
JF - Cell host & microbe
JO - Cell Host Microbe
VL - 23
IS - 1
N2 - The tuberculosis vaccine bacillus Calmette-Guérin (BCG) has heterologous beneficial effects against non-related infections. The basis of these effects has been poorly explored in humans. In a randomized placebo-controlled human challenge study, we found that BCG vaccination induced genome-wide epigenetic reprograming of monocytes and protected against experimental infection with an attenuated yellow fever virus vaccine strain. Epigenetic reprogramming was accompanied by functional changes indicative of trained immunity. Reduction of viremia was highly correlated with the upregulation of IL-1β, a heterologous cytokine associated with the induction of trained immunity, but not with the specific IFNγ response. The importance of IL-1β for the induction of trained immunity was validated through genetic, epigenetic, and immunological studies. In conclusion, BCG induces epigenetic reprogramming in human monocytes in vivo, followed by functional reprogramming and protection against non-related viral infections, with a key role for IL-1β as a mediator of trained immunity responses.
SN - 1934-6069
UR - https://www.unboundmedicine.com/medline/citation/29324233/full_citation
DB - PRIME
DP - Unbound Medicine
ER -