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Dietary Carotenoid Intakes and Prostate Cancer Risk: A Case-Control Study from Vietnam.

Abstract

The incidence of prostate cancer has increased in Vietnam, but there have been few studies of the risk factors associated with this change. This retrospective case-control study investigated the relation of the intake of carotenoids and their food sources to prostate cancer risk. A sample of 652 participants (244 incident prostate cancer patients, aged 64-75 years, and 408 age frequency-matched controls) were recruited in Ho Chi Minh City during 2013-2015. The habitual diet was ascertained with a validated food-frequency questionnaire, and other factors including demographic and lifestyle characteristics were assessed via face-to-face interviews by trained nurses. Multivariate-adjusted odds ratios (OR) and 95% confidence intervals (CI) were estimated using unconditional logistic regression models. The risk of prostate cancer decreased with increasing intakes of lycopene, tomatoes, and carrots; the respective ORs (95% CIs) were 0.46 (0.27, 0.77), 0.39 (0.23, 0.66), and 0.35 (0.21, 0.58), when comparing the highest with the lowest tertile of intake (p for trend < 0.01). No statistically significant associations were found for the intake of α-carotene, β-carotene, β-cryptoxanthin, lutein, zeaxanthin, and major food sources of carotenoids. In conclusion, Vietnamese men with a higher intake of lycopene, tomatoes, and carrots may have a lower risk of prostate cancer. However, large prospective studies are needed in this population to confirm this finding.

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  • Authors+Show Affiliations

    ,

    National Institute of Hygiene and Epidemiology, Hanoi 100000, Vietnam. hdongyk97@gmail.com.

    ,

    School of Public Health, Curtin University, Perth, WA 6102, Australia. minh.pn@tnu.edu.vn. Thai Nguyen University of Medicine and Pharmacy, Thai Nguyen 250000, Vietnam. minh.pn@tnu.edu.vn.

    ,

    School of Public Health, Curtin University, Perth, WA 6102, Australia. andy.lee@curtin.edu.au.

    ,

    National Institute of Hygiene and Epidemiology, Hanoi 100000, Vietnam. trannhuduong@gmail.com.

    School of Public Health, Curtin University, Perth, WA 6102, Australia. c.binns@curtin.edu.au.

    Source

    Nutrients 10:1 2018 Jan 11 pg

    MeSH

    Aged
    Anticarcinogenic Agents
    Carotenoids
    Chi-Square Distribution
    Cross-Sectional Studies
    Diet
    Diet Surveys
    Humans
    Incidence
    Logistic Models
    Male
    Middle Aged
    Multivariate Analysis
    Odds Ratio
    Prostatic Neoplasms
    Protective Factors
    Recommended Dietary Allowances
    Retrospective Studies
    Risk Factors
    Risk Reduction Behavior
    Time Factors
    Vietnam

    Pub Type(s)

    Journal Article

    Language

    eng

    PubMed ID

    29324670

    Citation

    Van Hoang, Dong, et al. "Dietary Carotenoid Intakes and Prostate Cancer Risk: a Case-Control Study From Vietnam." Nutrients, vol. 10, no. 1, 2018.
    Van Hoang D, Pham NM, Lee AH, et al. Dietary Carotenoid Intakes and Prostate Cancer Risk: A Case-Control Study from Vietnam. Nutrients. 2018;10(1).
    Van Hoang, D., Pham, N. M., Lee, A. H., Tran, D. N., & Binns, C. W. (2018). Dietary Carotenoid Intakes and Prostate Cancer Risk: A Case-Control Study from Vietnam. Nutrients, 10(1), doi:10.3390/nu10010070.
    Van Hoang D, et al. Dietary Carotenoid Intakes and Prostate Cancer Risk: a Case-Control Study From Vietnam. Nutrients. 2018 Jan 11;10(1) PubMed PMID: 29324670.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Dietary Carotenoid Intakes and Prostate Cancer Risk: A Case-Control Study from Vietnam. AU - Van Hoang,Dong, AU - Pham,Ngoc Minh, AU - Lee,Andy H, AU - Tran,Duong Nhu, AU - Binns,Colin W, Y1 - 2018/01/11/ PY - 2017/11/28/received PY - 2018/01/09/revised PY - 2018/01/09/accepted PY - 2018/1/12/entrez PY - 2018/1/13/pubmed PY - 2018/8/7/medline KW - Vietnam KW - carotenoids KW - case-control study KW - epidemiology KW - prostate cancer JF - Nutrients JO - Nutrients VL - 10 IS - 1 N2 - The incidence of prostate cancer has increased in Vietnam, but there have been few studies of the risk factors associated with this change. This retrospective case-control study investigated the relation of the intake of carotenoids and their food sources to prostate cancer risk. A sample of 652 participants (244 incident prostate cancer patients, aged 64-75 years, and 408 age frequency-matched controls) were recruited in Ho Chi Minh City during 2013-2015. The habitual diet was ascertained with a validated food-frequency questionnaire, and other factors including demographic and lifestyle characteristics were assessed via face-to-face interviews by trained nurses. Multivariate-adjusted odds ratios (OR) and 95% confidence intervals (CI) were estimated using unconditional logistic regression models. The risk of prostate cancer decreased with increasing intakes of lycopene, tomatoes, and carrots; the respective ORs (95% CIs) were 0.46 (0.27, 0.77), 0.39 (0.23, 0.66), and 0.35 (0.21, 0.58), when comparing the highest with the lowest tertile of intake (p for trend < 0.01). No statistically significant associations were found for the intake of α-carotene, β-carotene, β-cryptoxanthin, lutein, zeaxanthin, and major food sources of carotenoids. In conclusion, Vietnamese men with a higher intake of lycopene, tomatoes, and carrots may have a lower risk of prostate cancer. However, large prospective studies are needed in this population to confirm this finding. SN - 2072-6643 UR - https://www.unboundmedicine.com/medline/citation/29324670/Dietary_Carotenoid_Intakes_and_Prostate_Cancer_Risk:_A_Case_Control_Study_from_Vietnam_ L2 - http://www.mdpi.com/resolver?pii=nu10010070 DB - PRIME DP - Unbound Medicine ER -