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The effects of interleukin 2 and rAd-p53 as a treatment for glioblastoma.

Abstract

Interleukin 2 (IL-2) is an anti-cancer cytokine that stimulates T cell propagation, triggering innate and adaptive immunity. IL-2 has been used for cancer therapy and has achieved curative effects. Recombinant adenovirus p53 injection (rAd‑p53) is a gene therapeutic agent that may improve the prognosis of patients with glioblastoma (GBM). In the present study, the effect of combined IL‑2 and rAd‑p53 treatment was studied. The ability of IL‑2 to stimulate immunoregulation and the ability of p53 to induce apoptosis for GBM was researched in the GBM tumor model. In addition, the activity of IL‑2 was analyzed. The antitumor potential of IL‑2 and rAd‑p53 was studied using xenograph mice carrying GBM cells. Tumor‑specific CD4+ and CD8+ T cells were also analyzed in the GBM‑bearing models. The results demonstrated that IL‑2 and rAd‑p53 not only stimulated tumor‑specific cytotoxic T‑lymphocyte responses and increased regulatory CD4+ and cytotoxic CD8+ T cell proliferation, however additionally increased expression of apoptosis‑associated genes. The treatment with IL‑2 and rAd‑p53 resulted in tumor regression and prolonged the survival of glioma‑bearing mice. Taken together, a combination of IL‑2 and rAd‑p53 treatment combines the effects of immunotherapy and oncolytic therapy and may be a comprehensive therapeutic schedule for clinical application in future cancer therapies.

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  • Authors+Show Affiliations

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    Department of Neurosurgery, Tianjin Nankai Hospital, Tianjin 300100, P.R. China.

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    Department of Neurosurgery, Tianjin Nankai Hospital, Tianjin 300100, P.R. China.

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    Department of Neurosurgery, Tianjin Nankai Hospital, Tianjin 300100, P.R. China.

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    Department of Neurosurgery, Tianjin Nankai Hospital, Tianjin 300100, P.R. China.

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    Department of Neurosurgery, Tianjin Nankai Hospital, Tianjin 300100, P.R. China.

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    Department of Neurosurgery, Tianjin Nankai Hospital, Tianjin 300100, P.R. China.

    Department of Neurosurgery, Tianjin Nankai Hospital, Tianjin 300100, P.R. China.

    Source

    Molecular medicine reports 17:3 2018 Mar pg 4853-4859

    Pub Type(s)

    Journal Article

    Language

    eng

    PubMed ID

    29328445