The role of irreversibly sickled cells in reducing the osmotic fragility of red cells in sickle cell anemia.
Acta Physiol Pharmacol Latinoam. 1985; 35(1):49-56.AP

Abstract

The measurement of the osmotic fragility of red blood cells of 7 patients with sickle cell anemia and 5 controls was carried out for the unfractionated blood and for cells of the top and bottom layers after centrifugation. The erythrocytes from all patients with sickle cell anemia were more resistant to the osmotic lysis than normal erythrocytes, and the resistance of the bottom layer cells was greater than that of the top layer cells for all cases of sickle cell anemia. In addition, in the cases of sickle cell anemia, the bottom layer contained an elevated percentage (5.0% - 23.7%) of irreversible sickled cells, as compared to 1.3% - 3.6% in the top layer. The decreased osmotic fragility of the erythrocytes in sickle cell anemia probably results from the cell damage which accompanies repeated sickle-unsickle cycles and which reaches its maximum in the irreversibly sickled cells.

Authors

Figueiredo MS

No affiliation info available

Zago MA

No affiliation info available

MeSH

Anemia, Sickle CellErythrocytes, AbnormalHumansOsmotic Fragility

Pub Type(s)

Journal Article

Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

2932889

Citation

Figueiredo, M S., and M A. Zago. "The Role of Irreversibly Sickled Cells in Reducing the Osmotic Fragility of Red Cells in Sickle Cell Anemia." Acta Physiologica Et Pharmacologica Latinoamericana : Organo De La Asociacion Latinoamericana De Ciencias Fisiologicas Y De La Asociacion Latinoamericana De Farmacologia, vol. 35, no. 1, 1985, pp. 49-56.

Figueiredo MS, Zago MA. The role of irreversibly sickled cells in reducing the osmotic fragility of red cells in sickle cell anemia. Acta Physiol Pharmacol Latinoam. 1985;35(1):49-56.

Figueiredo, M. S., & Zago, M. A. (1985). The role of irreversibly sickled cells in reducing the osmotic fragility of red cells in sickle cell anemia. Acta Physiologica Et Pharmacologica Latinoamericana : Organo De La Asociacion Latinoamericana De Ciencias Fisiologicas Y De La Asociacion Latinoamericana De Farmacologia, 35(1), 49-56.

Figueiredo MS, Zago MA. The Role of Irreversibly Sickled Cells in Reducing the Osmotic Fragility of Red Cells in Sickle Cell Anemia. Acta Physiol Pharmacol Latinoam. 1985;35(1):49-56. PubMed PMID: 2932889.

* Article titles in AMA citation format should be in sentence-case

TY - JOUR T1 - The role of irreversibly sickled cells in reducing the osmotic fragility of red cells in sickle cell anemia. AU - Figueiredo,M S, AU - Zago,M A, PY - 1985/1/1/pubmed PY - 1985/1/1/medline PY - 1985/1/1/entrez SP - 49 EP - 56 JF - Acta physiologica et pharmacologica latinoamericana : organo de la Asociacion Latinoamericana de Ciencias Fisiologicas y de la Asociacion Latinoamericana de Farmacologia JO - Acta Physiol Pharmacol Latinoam VL - 35 IS - 1 N2 - The measurement of the osmotic fragility of red blood cells of 7 patients with sickle cell anemia and 5 controls was carried out for the unfractionated blood and for cells of the top and bottom layers after centrifugation. The erythrocytes from all patients with sickle cell anemia were more resistant to the osmotic lysis than normal erythrocytes, and the resistance of the bottom layer cells was greater than that of the top layer cells for all cases of sickle cell anemia. In addition, in the cases of sickle cell anemia, the bottom layer contained an elevated percentage (5.0% - 23.7%) of irreversible sickled cells, as compared to 1.3% - 3.6% in the top layer. The decreased osmotic fragility of the erythrocytes in sickle cell anemia probably results from the cell damage which accompanies repeated sickle-unsickle cycles and which reaches its maximum in the irreversibly sickled cells. SN - 0326-6656 UR - https://www.unboundmedicine.com/medline/citation/2932889/The_role_of_irreversibly_sickled_cells_in_reducing_the_osmotic_fragility_of_red_cells_in_sickle_cell_anemia_ DB - PRIME DP - Unbound Medicine ER -

Tags

The role of irreversibly sickled cells in reducing the osmotic fragility of red cells in sickle cell anemia.Acta Physiol Pharmacol Latinoam. 1985; 35(1):49-56.AP