Tags

Type your tag names separated by a space and hit enter

Different protein composition of low-calorie diet differently impacts adipokine profile irrespective of weight loss in overweight and obese women.
Nutr Metab Cardiovasc Dis. 2018 02; 28(2):133-142.NM

Abstract

BACKGROUND AND AIMS

High-protein (HP) diets have shown benefits in cardiometabolic markers such as insulin or triglycerides but the responsible mechanisms are not known. We aimed to assess the effect of three energy-restricted diets with different protein contents (20%, 27%, and 35%; ∼80% coming from animal source) on plasma adipokine concentration and its association with changes in cardiometabolic markers.

METHODS

Seventy-six women (BMI 32.8 ± 2.93) were randomized to one of three calorie-reduced diets, with protein, 20%, 27%, or 35%; carbohydrates, 50%, 43%, or 35%; and fat, 30%, for 3 months. Plasma adipokine (leptin, resistin, adiponectin, and retinol-binding protein 4; RBP4) levels were assessed.

RESULTS

After 3 months, leptin concentration decreased in all groups without differences among them, while resistin levels remained unchanged. Adiponectin concentration heterogeneously changed in all groups (P for trend = 0.165) and resistin concentration did not significantly change. RPB4 significantly decreased by -17.5% (-31.7, -3.22) in 35%-protein diet (P for trend = 0.024 among diets). Triglycerides improved in women following the 35%-protein diet regardless of weight loss; RBP4 variation significantly influenced triglyceride concentration change by 24.9% and 25.9% when comparing 27%- and 35%- with 20%-protein diet, respectively.

CONCLUSIONS

A 35%-protein diet induced a decrease in RBP4 regardless of weight loss, which was directly associated with triglyceride concentration improvement. These findings suggest that HP diets improve the cardiometabolic profile, at least in part, through changes in adipokine secretion. Whether this beneficial effect of HP diet is due to improvements in hepatic or adipose tissue functionality should be elucidated.

CLINICAL TRIAL REGISTRATION

The clinical trial has been registered in ClinicalTrials.gov (Identifier: NCT02160496).

Authors+Show Affiliations

Unidad Clínica y de Investigación en Lípidos y Arteriosclerosis, Hospital Universitario Miguel Servet, Instituto de Investigación Sanitaria Aragón (IIS Aragón), Universidad de Zaragoza, CIBERCV, Zaragoza, Spain. Electronic address: mateo@iisaragon.es.Unidad Clínica y de Investigación en Lípidos y Arteriosclerosis, Hospital Universitario Miguel Servet, Instituto de Investigación Sanitaria Aragón (IIS Aragón), Universidad de Zaragoza, CIBERCV, Zaragoza, Spain.Unidad Clínica y de Investigación en Lípidos y Arteriosclerosis, Hospital Universitario Miguel Servet, Instituto de Investigación Sanitaria Aragón (IIS Aragón), Universidad de Zaragoza, CIBERCV, Zaragoza, Spain.Unidad Clínica y de Investigación en Lípidos y Arteriosclerosis, Hospital Universitario Miguel Servet, Instituto de Investigación Sanitaria Aragón (IIS Aragón), Universidad de Zaragoza, CIBERCV, Zaragoza, Spain.Unidad Clínica y de Investigación en Lípidos y Arteriosclerosis, Hospital Universitario Miguel Servet, Instituto de Investigación Sanitaria Aragón (IIS Aragón), Universidad de Zaragoza, CIBERCV, Zaragoza, Spain.Unidad Clínica y de Investigación en Lípidos y Arteriosclerosis, Hospital Universitario Miguel Servet, Instituto de Investigación Sanitaria Aragón (IIS Aragón), Universidad de Zaragoza, CIBERCV, Zaragoza, Spain.Unidad Clínica y de Investigación en Lípidos y Arteriosclerosis, Hospital Universitario Miguel Servet, Instituto de Investigación Sanitaria Aragón (IIS Aragón), Universidad de Zaragoza, CIBERCV, Zaragoza, Spain.Tufts Friedman School of Nutrition Science & Policy, Boston, MA, USA.Unidad Clínica y de Investigación en Lípidos y Arteriosclerosis, Hospital Universitario Miguel Servet, Instituto de Investigación Sanitaria Aragón (IIS Aragón), Universidad de Zaragoza, CIBERCV, Zaragoza, Spain.Unidad Clínica y de Investigación en Lípidos y Arteriosclerosis, Hospital Universitario Miguel Servet, Instituto de Investigación Sanitaria Aragón (IIS Aragón), Universidad de Zaragoza, CIBERCV, Zaragoza, Spain.

Pub Type(s)

Comparative Study
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

29329923

Citation

Mateo-Gallego, R, et al. "Different Protein Composition of Low-calorie Diet Differently Impacts Adipokine Profile Irrespective of Weight Loss in Overweight and Obese Women." Nutrition, Metabolism, and Cardiovascular Diseases : NMCD, vol. 28, no. 2, 2018, pp. 133-142.
Mateo-Gallego R, Lamiquiz-Moneo I, Perez-Calahorra S, et al. Different protein composition of low-calorie diet differently impacts adipokine profile irrespective of weight loss in overweight and obese women. Nutr Metab Cardiovasc Dis. 2018;28(2):133-142.
Mateo-Gallego, R., Lamiquiz-Moneo, I., Perez-Calahorra, S., Marco-Benedí, V., Bea, A. M., Baila-Rueda, L., Laclaustra, M., Peñalvo, J. L., Civeira, F., & Cenarro, A. (2018). Different protein composition of low-calorie diet differently impacts adipokine profile irrespective of weight loss in overweight and obese women. Nutrition, Metabolism, and Cardiovascular Diseases : NMCD, 28(2), 133-142. https://doi.org/10.1016/j.numecd.2017.10.024
Mateo-Gallego R, et al. Different Protein Composition of Low-calorie Diet Differently Impacts Adipokine Profile Irrespective of Weight Loss in Overweight and Obese Women. Nutr Metab Cardiovasc Dis. 2018;28(2):133-142. PubMed PMID: 29329923.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Different protein composition of low-calorie diet differently impacts adipokine profile irrespective of weight loss in overweight and obese women. AU - Mateo-Gallego,R, AU - Lamiquiz-Moneo,I, AU - Perez-Calahorra,S, AU - Marco-Benedí,V, AU - Bea,A M, AU - Baila-Rueda,L, AU - Laclaustra,M, AU - Peñalvo,J L, AU - Civeira,F, AU - Cenarro,A, Y1 - 2017/11/04/ PY - 2017/05/19/received PY - 2017/10/27/revised PY - 2017/10/30/accepted PY - 2018/1/14/pubmed PY - 2019/3/15/medline PY - 2018/1/14/entrez KW - Adipokines KW - Adipose tissue KW - Obesity KW - Overweight KW - Protein KW - Weight loss SP - 133 EP - 142 JF - Nutrition, metabolism, and cardiovascular diseases : NMCD JO - Nutr Metab Cardiovasc Dis VL - 28 IS - 2 N2 - BACKGROUND AND AIMS: High-protein (HP) diets have shown benefits in cardiometabolic markers such as insulin or triglycerides but the responsible mechanisms are not known. We aimed to assess the effect of three energy-restricted diets with different protein contents (20%, 27%, and 35%; ∼80% coming from animal source) on plasma adipokine concentration and its association with changes in cardiometabolic markers. METHODS: Seventy-six women (BMI 32.8 ± 2.93) were randomized to one of three calorie-reduced diets, with protein, 20%, 27%, or 35%; carbohydrates, 50%, 43%, or 35%; and fat, 30%, for 3 months. Plasma adipokine (leptin, resistin, adiponectin, and retinol-binding protein 4; RBP4) levels were assessed. RESULTS: After 3 months, leptin concentration decreased in all groups without differences among them, while resistin levels remained unchanged. Adiponectin concentration heterogeneously changed in all groups (P for trend = 0.165) and resistin concentration did not significantly change. RPB4 significantly decreased by -17.5% (-31.7, -3.22) in 35%-protein diet (P for trend = 0.024 among diets). Triglycerides improved in women following the 35%-protein diet regardless of weight loss; RBP4 variation significantly influenced triglyceride concentration change by 24.9% and 25.9% when comparing 27%- and 35%- with 20%-protein diet, respectively. CONCLUSIONS: A 35%-protein diet induced a decrease in RBP4 regardless of weight loss, which was directly associated with triglyceride concentration improvement. These findings suggest that HP diets improve the cardiometabolic profile, at least in part, through changes in adipokine secretion. Whether this beneficial effect of HP diet is due to improvements in hepatic or adipose tissue functionality should be elucidated. CLINICAL TRIAL REGISTRATION: The clinical trial has been registered in ClinicalTrials.gov (Identifier: NCT02160496). SN - 1590-3729 UR - https://www.unboundmedicine.com/medline/citation/29329923/Different_protein_composition_of_low_calorie_diet_differently_impacts_adipokine_profile_irrespective_of_weight_loss_in_overweight_and_obese_women_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0939-4753(17)30264-8 DB - PRIME DP - Unbound Medicine ER -