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White matter volume loss in amyotrophic lateral sclerosis: A meta-analysis of voxel-based morphometry studies.

Abstract

Structural neuroimaging studies of white matter (WM) volume in amyotrophic lateral sclerosis (ALS) using voxel-based morphometry (VBM) have yielded inconsistent findings. This study aimed to perform a quantitative voxel-based meta-analysis using effect-size signed differential mapping (ES-SDM) to establish a statistical consensus between published studies for WM volume alterations in ALS. The pooled meta-analysis revealed significant WM volume losses in the bilateral supplementary motor areas (SMAs), bilateral precentral gyri (PGs), left middle cerebellar peduncle and right cerebellum in patients with ALS, involving the corticospinal tract (CST), interhemispheric fibers, subcortical arcuate fibers, projection fibers to the striatum and cortico-ponto-cerebellar tract. The meta-regression showed that the ALS functional rating scale-revised (ALSFRS-R) was positively correlated with decreased WM volume in the bilateral SMAs, whereas illness duration was negatively correlated with WM volume reduction in the right SMA. This study provides a thorough profile of WM volume loss in ALS and robust evidence that ALS is a multisystem neurodegenerative disease that involves a variety of subcortical WM tracts extending beyond motor cortex involvement.

Authors+Show Affiliations

Huaxi MR Research Center (HMRRC), Department of Radiology, West China Hospital, Sichuan University, Chengdu 610041, Sichuan, China; Department of Radiology, The Affiliated Hospital of Southwest Medical University, Luzhou 646000, Sichuan, China.Huaxi MR Research Center (HMRRC), Department of Radiology, West China Hospital, Sichuan University, Chengdu 610041, Sichuan, China.Laboratory of Stem Cell Biology, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu 610041, Sichuan, China. Electronic address: hyzhu_hmrrc@126.com.Department of Psychiatry, State Key Lab of Biotherapy, West China Hospital, Sichuan University, Chengdu 610041, Sichuan, China.Department of Oncology, State Key Lab of Biotherapy, West China Hospital, Sichuan University, Chengdu 610041, Sichuan, China.National Engineering Research Center for Biomaterials, Sichuan University, Chengdu 610064, Sichuan, China.National Engineering Research Center for Biomaterials, Sichuan University, Chengdu 610064, Sichuan, China.Huaxi MR Research Center (HMRRC), Department of Radiology, West China Hospital, Sichuan University, Chengdu 610041, Sichuan, China.Huaxi MR Research Center (HMRRC), Department of Radiology, West China Hospital, Sichuan University, Chengdu 610041, Sichuan, China.Huaxi MR Research Center (HMRRC), Department of Radiology, West China Hospital, Sichuan University, Chengdu 610041, Sichuan, China; Department of Psychology, School of Public Administration, Sichuan University, Chengdu 610041, Sichuan, China; Department of Psychoradiology, Chengdu Mental Health Center, Chengdu, China.

Pub Type(s)

Journal Article
Meta-Analysis
Research Support, Non-U.S. Gov't
Systematic Review

Language

eng

PubMed ID

29330136

Citation

Chen, Guangxiang, et al. "White Matter Volume Loss in Amyotrophic Lateral Sclerosis: a Meta-analysis of Voxel-based Morphometry Studies." Progress in Neuro-psychopharmacology & Biological Psychiatry, vol. 83, 2018, pp. 110-117.
Chen G, Zhou B, Zhu H, et al. White matter volume loss in amyotrophic lateral sclerosis: A meta-analysis of voxel-based morphometry studies. Prog Neuropsychopharmacol Biol Psychiatry. 2018;83:110-117.
Chen, G., Zhou, B., Zhu, H., Kuang, W., Bi, F., Ai, H., Gu, Z., Huang, X., Lui, S., & Gong, Q. (2018). White matter volume loss in amyotrophic lateral sclerosis: A meta-analysis of voxel-based morphometry studies. Progress in Neuro-psychopharmacology & Biological Psychiatry, 83, 110-117. https://doi.org/10.1016/j.pnpbp.2018.01.007
Chen G, et al. White Matter Volume Loss in Amyotrophic Lateral Sclerosis: a Meta-analysis of Voxel-based Morphometry Studies. Prog Neuropsychopharmacol Biol Psychiatry. 2018 04 20;83:110-117. PubMed PMID: 29330136.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - White matter volume loss in amyotrophic lateral sclerosis: A meta-analysis of voxel-based morphometry studies. AU - Chen,Guangxiang, AU - Zhou,Baiwan, AU - Zhu,Hongyan, AU - Kuang,Weihong, AU - Bi,Feng, AU - Ai,Hua, AU - Gu,Zhongwei, AU - Huang,Xiaoqi, AU - Lui,Su, AU - Gong,Qiyong, Y1 - 2018/01/09/ PY - 2017/09/30/received PY - 2017/12/23/revised PY - 2018/01/09/accepted PY - 2018/1/14/pubmed PY - 2019/1/4/medline PY - 2018/1/14/entrez KW - Amyotrophic lateral sclerosis KW - Meta-analysis KW - Psychoradiology KW - Voxel-based morphometry (VBM) KW - White matter (WM) SP - 110 EP - 117 JF - Progress in neuro-psychopharmacology & biological psychiatry JO - Prog. Neuropsychopharmacol. Biol. Psychiatry VL - 83 N2 - Structural neuroimaging studies of white matter (WM) volume in amyotrophic lateral sclerosis (ALS) using voxel-based morphometry (VBM) have yielded inconsistent findings. This study aimed to perform a quantitative voxel-based meta-analysis using effect-size signed differential mapping (ES-SDM) to establish a statistical consensus between published studies for WM volume alterations in ALS. The pooled meta-analysis revealed significant WM volume losses in the bilateral supplementary motor areas (SMAs), bilateral precentral gyri (PGs), left middle cerebellar peduncle and right cerebellum in patients with ALS, involving the corticospinal tract (CST), interhemispheric fibers, subcortical arcuate fibers, projection fibers to the striatum and cortico-ponto-cerebellar tract. The meta-regression showed that the ALS functional rating scale-revised (ALSFRS-R) was positively correlated with decreased WM volume in the bilateral SMAs, whereas illness duration was negatively correlated with WM volume reduction in the right SMA. This study provides a thorough profile of WM volume loss in ALS and robust evidence that ALS is a multisystem neurodegenerative disease that involves a variety of subcortical WM tracts extending beyond motor cortex involvement. SN - 1878-4216 UR - https://www.unboundmedicine.com/medline/citation/29330136/White_matter_volume_loss_in_amyotrophic_lateral_sclerosis:_A_meta_analysis_of_voxel_based_morphometry_studies_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0278-5846(17)30836-9 DB - PRIME DP - Unbound Medicine ER -