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Circulating Hormones and Mammographic Density in Premenopausal Women.
Horm Cancer. 2018 04; 9(2):117-127.HC

Abstract

Prior research suggests that several endogenous hormones in premenopausal women are associated with breast cancer risk; however, few studies have evaluated associations of endogenous hormones with mammographic density (MD) in premenopausal women. We conducted a cross-sectional study of plasma hormone levels in relation to MD among 634 cancer-free premenopausal women in the Nurses' Health Study II. We measured percent MD from screening mammograms using a computer-assisted method. We assayed estradiol, estrone, and estrone sulfate in blood samples timed in early follicular and mid-luteal phases of the menstrual cycle as well as testosterone, androstenedione, progesterone, dehydroepiandrosterone (DHEA), DHEA sulfate, sex hormone-binding globulin (SHBG), and anti-Müllerian hormone in luteal or untimed samples. We used multivariable linear regression to quantify the association of %MD with quartiles of each hormone, adjusting for age, body mass index, and breast cancer risk factors. Women in the highest quartile of follicular estradiol levels had significantly greater %MD compared to those in the lowest quartile [difference, 6.7 percentage points; 95% confidence interval (CI) 2.2, 11.3; p-trend < 0.001]. Similar associations were observed for follicular free estradiol but not luteal-phase estradiol. Also, women in the top (vs. bottom) quartile of free testosterone had significantly lower %MD (difference, - 4.7; 95% CI - 8.7, - 0.8; p-trend = 0.04). Higher SHBG was significantly associated with higher percent MD (difference, 4.8; 95% CI 1.1, 8.6; p-trend = 0.002). Percent MD was not strongly associated with other measured hormones. Results were similar in analyses that excluded women with anovulatory cycles. Our findings suggest that follicular estradiol and SHBG may play an important role in premenopausal percent MD.

Authors+Show Affiliations

Slone Epidemiology Center at Boston University, 72 East Concord Street, L-7, Boston, MA, 02118, USA. kab15@bu.edu.Channing Division of Network Medicine, Harvard Medical School and Brigham and Women's Hospital, Boston, MA, USA. Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA.Channing Division of Network Medicine, Harvard Medical School and Brigham and Women's Hospital, Boston, MA, USA. Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA. Department of Biostatistics and Epidemiology, School of Public Health and Health Sciences, University of Massachusetts Amherst, Amherst, MA, USA.Channing Division of Network Medicine, Harvard Medical School and Brigham and Women's Hospital, Boston, MA, USA. Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, MA, USA.Channing Division of Network Medicine, Harvard Medical School and Brigham and Women's Hospital, Boston, MA, USA. Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA.

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

29330698

Citation

Bertrand, Kimberly A., et al. "Circulating Hormones and Mammographic Density in Premenopausal Women." Hormones & Cancer, vol. 9, no. 2, 2018, pp. 117-127.
Bertrand KA, Eliassen AH, Hankinson SE, et al. Circulating Hormones and Mammographic Density in Premenopausal Women. Horm Cancer. 2018;9(2):117-127.
Bertrand, K. A., Eliassen, A. H., Hankinson, S. E., Rosner, B. A., & Tamimi, R. M. (2018). Circulating Hormones and Mammographic Density in Premenopausal Women. Hormones & Cancer, 9(2), 117-127. https://doi.org/10.1007/s12672-017-0321-6
Bertrand KA, et al. Circulating Hormones and Mammographic Density in Premenopausal Women. Horm Cancer. 2018;9(2):117-127. PubMed PMID: 29330698.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Circulating Hormones and Mammographic Density in Premenopausal Women. AU - Bertrand,Kimberly A, AU - Eliassen,A Heather, AU - Hankinson,Susan E, AU - Rosner,Bernard A, AU - Tamimi,Rulla M, Y1 - 2018/01/12/ PY - 2017/11/27/received PY - 2017/12/26/accepted PY - 2018/1/14/pubmed PY - 2019/4/9/medline PY - 2018/1/14/entrez SP - 117 EP - 127 JF - Hormones & cancer JO - Horm Cancer VL - 9 IS - 2 N2 - Prior research suggests that several endogenous hormones in premenopausal women are associated with breast cancer risk; however, few studies have evaluated associations of endogenous hormones with mammographic density (MD) in premenopausal women. We conducted a cross-sectional study of plasma hormone levels in relation to MD among 634 cancer-free premenopausal women in the Nurses' Health Study II. We measured percent MD from screening mammograms using a computer-assisted method. We assayed estradiol, estrone, and estrone sulfate in blood samples timed in early follicular and mid-luteal phases of the menstrual cycle as well as testosterone, androstenedione, progesterone, dehydroepiandrosterone (DHEA), DHEA sulfate, sex hormone-binding globulin (SHBG), and anti-Müllerian hormone in luteal or untimed samples. We used multivariable linear regression to quantify the association of %MD with quartiles of each hormone, adjusting for age, body mass index, and breast cancer risk factors. Women in the highest quartile of follicular estradiol levels had significantly greater %MD compared to those in the lowest quartile [difference, 6.7 percentage points; 95% confidence interval (CI) 2.2, 11.3; p-trend < 0.001]. Similar associations were observed for follicular free estradiol but not luteal-phase estradiol. Also, women in the top (vs. bottom) quartile of free testosterone had significantly lower %MD (difference, - 4.7; 95% CI - 8.7, - 0.8; p-trend = 0.04). Higher SHBG was significantly associated with higher percent MD (difference, 4.8; 95% CI 1.1, 8.6; p-trend = 0.002). Percent MD was not strongly associated with other measured hormones. Results were similar in analyses that excluded women with anovulatory cycles. Our findings suggest that follicular estradiol and SHBG may play an important role in premenopausal percent MD. SN - 1868-8500 UR - https://www.unboundmedicine.com/medline/citation/29330698/Circulating_Hormones_and_Mammographic_Density_in_Premenopausal_Women_ L2 - https://dx.doi.org/10.1007/s12672-017-0321-6 DB - PRIME DP - Unbound Medicine ER -