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Moderate-dose simvastatin therapy potentiates the effect of vitamin D on thyroid autoimmunity in levothyroxine-treated women with Hashimoto's thyroiditis and vitamin D insufficiency.

Abstract

BACKGROUND

Vitamin D preparations reduce titers of thyroid antibodies in women with autoimmune thyroiditis. The same effect was induced by high-dose, but not moderate-dose-, statin therapy. No previous study has investigated the impact of concomitant treatment with a statin and vitamin D on thyroid autoimmunity.

METHODS

The study included three matched groups of women with Hashimoto's thyroiditis and low vitamin D status. Groups B (n=19) and C (n=20) were treated with vitamin D (2000 IU daily). Because of coexistent hypercholesterolemia, groups A (n=18) and B received simvastatin (40mg daily). Plasma lipids, serum levels of thyrotropin, free thyroid hormones and 25-hydroxyvitamin D, as well as titers of thyroid peroxidase and thyroglobulin antibodies were measured at the beginning of the study and 6 months later.

RESULTS

At baseline, 25-hydroxyvitamin D levels inversely correlated with titers of thyroid antibodies. In groups A and B, simvastatin reduced plasma levels of total and LDL cholesterol. Simvastatin produced no effect on thyroid antibody titers. Vitamin D decreased titers of thyroid peroxidase antibodies, as well as tended to decrease titers of thyroglobulin antibodies. Simvastatin-vitamin D combination therapy reduced serum titers of thyroid peroxidase and thyroglobulin antibodies and this effect was stronger than the effect of simvastatin and vitamin D administered alone. Treatment-induced changes in thyroid antibody titers correlated with baseline antibody titers, baseline levels of 25-hydroxyvitamin and treatment-induced changes in 25-hydroxyvitamin.

CONCLUSIONS

The obtained results indicate that simvastatin may potentiate the impact of vitamin D on thyroid autoimmunity in vitamin D-deficient women with Hashimoto's thyroiditis.

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  • Authors+Show Affiliations

    ,

    Department of Internal Medicine and Clinical Pharmacology, Medical University of Silesia, Katowice, Poland. Electronic address: r.krysiak@interia.pl.

    ,

    Department of Internal Medicine and Clinical Pharmacology, Medical University of Silesia, Katowice, Poland.

    Department of Internal Medicine and Clinical Pharmacology, Medical University of Silesia, Katowice, Poland.

    Source

    Pharmacological reports : PR 70:1 2018 Feb pg 93-97

    MeSH

    Adult
    Autoantibodies
    Autoimmunity
    Biomarkers
    Cholesterol
    Dietary Supplements
    Drug Synergism
    Female
    Hashimoto Disease
    Humans
    Hydroxymethylglutaryl-CoA Reductase Inhibitors
    Hypercholesterolemia
    Middle Aged
    Simvastatin
    Thyroid Hormones
    Thyrotropin
    Treatment Outcome
    Vitamin D
    Vitamin D Deficiency

    Pub Type(s)

    Journal Article

    Language

    eng

    PubMed ID

    29331793

    Citation

    Krysiak, Robert, et al. "Moderate-dose Simvastatin Therapy Potentiates the Effect of Vitamin D On Thyroid Autoimmunity in Levothyroxine-treated Women With Hashimoto's Thyroiditis and Vitamin D Insufficiency." Pharmacological Reports : PR, vol. 70, no. 1, 2018, pp. 93-97.
    Krysiak R, Szkróbka W, Okopień B. Moderate-dose simvastatin therapy potentiates the effect of vitamin D on thyroid autoimmunity in levothyroxine-treated women with Hashimoto's thyroiditis and vitamin D insufficiency. Pharmacol Rep. 2018;70(1):93-97.
    Krysiak, R., Szkróbka, W., & Okopień, B. (2018). Moderate-dose simvastatin therapy potentiates the effect of vitamin D on thyroid autoimmunity in levothyroxine-treated women with Hashimoto's thyroiditis and vitamin D insufficiency. Pharmacological Reports : PR, 70(1), pp. 93-97. doi:10.1016/j.pharep.2017.07.019.
    Krysiak R, Szkróbka W, Okopień B. Moderate-dose Simvastatin Therapy Potentiates the Effect of Vitamin D On Thyroid Autoimmunity in Levothyroxine-treated Women With Hashimoto's Thyroiditis and Vitamin D Insufficiency. Pharmacol Rep. 2018;70(1):93-97. PubMed PMID: 29331793.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Moderate-dose simvastatin therapy potentiates the effect of vitamin D on thyroid autoimmunity in levothyroxine-treated women with Hashimoto's thyroiditis and vitamin D insufficiency. AU - Krysiak,Robert, AU - Szkróbka,Witold, AU - Okopień,Bogusław, Y1 - 2017/07/27/ PY - 2017/06/26/received PY - 2017/07/19/revised PY - 2017/07/25/accepted PY - 2018/1/15/pubmed PY - 2018/9/8/medline PY - 2018/1/15/entrez KW - Hypothalamic-pituitary-thyroid axis KW - Statins KW - Thyroiditis KW - Vitamin D SP - 93 EP - 97 JF - Pharmacological reports : PR JO - Pharmacol Rep VL - 70 IS - 1 N2 - BACKGROUND: Vitamin D preparations reduce titers of thyroid antibodies in women with autoimmune thyroiditis. The same effect was induced by high-dose, but not moderate-dose-, statin therapy. No previous study has investigated the impact of concomitant treatment with a statin and vitamin D on thyroid autoimmunity. METHODS: The study included three matched groups of women with Hashimoto's thyroiditis and low vitamin D status. Groups B (n=19) and C (n=20) were treated with vitamin D (2000 IU daily). Because of coexistent hypercholesterolemia, groups A (n=18) and B received simvastatin (40mg daily). Plasma lipids, serum levels of thyrotropin, free thyroid hormones and 25-hydroxyvitamin D, as well as titers of thyroid peroxidase and thyroglobulin antibodies were measured at the beginning of the study and 6 months later. RESULTS: At baseline, 25-hydroxyvitamin D levels inversely correlated with titers of thyroid antibodies. In groups A and B, simvastatin reduced plasma levels of total and LDL cholesterol. Simvastatin produced no effect on thyroid antibody titers. Vitamin D decreased titers of thyroid peroxidase antibodies, as well as tended to decrease titers of thyroglobulin antibodies. Simvastatin-vitamin D combination therapy reduced serum titers of thyroid peroxidase and thyroglobulin antibodies and this effect was stronger than the effect of simvastatin and vitamin D administered alone. Treatment-induced changes in thyroid antibody titers correlated with baseline antibody titers, baseline levels of 25-hydroxyvitamin and treatment-induced changes in 25-hydroxyvitamin. CONCLUSIONS: The obtained results indicate that simvastatin may potentiate the impact of vitamin D on thyroid autoimmunity in vitamin D-deficient women with Hashimoto's thyroiditis. SN - 1734-1140 UR - https://www.unboundmedicine.com/medline/citation/29331793/Moderate_dose_simvastatin_therapy_potentiates_the_effect_of_vitamin_D_on_thyroid_autoimmunity_in_levothyroxine_treated_women_with_Hashimoto's_thyroiditis_and_vitamin_D_insufficiency_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1734-1140(17)30443-7 DB - PRIME DP - Unbound Medicine ER -