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Moderate-dose simvastatin therapy potentiates the effect of vitamin D on thyroid autoimmunity in levothyroxine-treated women with Hashimoto's thyroiditis and vitamin D insufficiency.
Pharmacol Rep 2018; 70(1):93-97PR

Abstract

BACKGROUND

Vitamin D preparations reduce titers of thyroid antibodies in women with autoimmune thyroiditis. The same effect was induced by high-dose, but not moderate-dose-, statin therapy. No previous study has investigated the impact of concomitant treatment with a statin and vitamin D on thyroid autoimmunity.

METHODS

The study included three matched groups of women with Hashimoto's thyroiditis and low vitamin D status. Groups B (n=19) and C (n=20) were treated with vitamin D (2000 IU daily). Because of coexistent hypercholesterolemia, groups A (n=18) and B received simvastatin (40mg daily). Plasma lipids, serum levels of thyrotropin, free thyroid hormones and 25-hydroxyvitamin D, as well as titers of thyroid peroxidase and thyroglobulin antibodies were measured at the beginning of the study and 6 months later.

RESULTS

At baseline, 25-hydroxyvitamin D levels inversely correlated with titers of thyroid antibodies. In groups A and B, simvastatin reduced plasma levels of total and LDL cholesterol. Simvastatin produced no effect on thyroid antibody titers. Vitamin D decreased titers of thyroid peroxidase antibodies, as well as tended to decrease titers of thyroglobulin antibodies. Simvastatin-vitamin D combination therapy reduced serum titers of thyroid peroxidase and thyroglobulin antibodies and this effect was stronger than the effect of simvastatin and vitamin D administered alone. Treatment-induced changes in thyroid antibody titers correlated with baseline antibody titers, baseline levels of 25-hydroxyvitamin and treatment-induced changes in 25-hydroxyvitamin.

CONCLUSIONS

The obtained results indicate that simvastatin may potentiate the impact of vitamin D on thyroid autoimmunity in vitamin D-deficient women with Hashimoto's thyroiditis.

Authors+Show Affiliations

Department of Internal Medicine and Clinical Pharmacology, Medical University of Silesia, Katowice, Poland. Electronic address: r.krysiak@interia.pl.Department of Internal Medicine and Clinical Pharmacology, Medical University of Silesia, Katowice, Poland.Department of Internal Medicine and Clinical Pharmacology, Medical University of Silesia, Katowice, Poland.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

29331793

Citation

Krysiak, Robert, et al. "Moderate-dose Simvastatin Therapy Potentiates the Effect of Vitamin D On Thyroid Autoimmunity in Levothyroxine-treated Women With Hashimoto's Thyroiditis and Vitamin D Insufficiency." Pharmacological Reports : PR, vol. 70, no. 1, 2018, pp. 93-97.
Krysiak R, Szkróbka W, Okopień B. Moderate-dose simvastatin therapy potentiates the effect of vitamin D on thyroid autoimmunity in levothyroxine-treated women with Hashimoto's thyroiditis and vitamin D insufficiency. Pharmacol Rep. 2018;70(1):93-97.
Krysiak, R., Szkróbka, W., & Okopień, B. (2018). Moderate-dose simvastatin therapy potentiates the effect of vitamin D on thyroid autoimmunity in levothyroxine-treated women with Hashimoto's thyroiditis and vitamin D insufficiency. Pharmacological Reports : PR, 70(1), pp. 93-97. doi:10.1016/j.pharep.2017.07.019.
Krysiak R, Szkróbka W, Okopień B. Moderate-dose Simvastatin Therapy Potentiates the Effect of Vitamin D On Thyroid Autoimmunity in Levothyroxine-treated Women With Hashimoto's Thyroiditis and Vitamin D Insufficiency. Pharmacol Rep. 2018;70(1):93-97. PubMed PMID: 29331793.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Moderate-dose simvastatin therapy potentiates the effect of vitamin D on thyroid autoimmunity in levothyroxine-treated women with Hashimoto's thyroiditis and vitamin D insufficiency. AU - Krysiak,Robert, AU - Szkróbka,Witold, AU - Okopień,Bogusław, Y1 - 2017/07/27/ PY - 2017/06/26/received PY - 2017/07/19/revised PY - 2017/07/25/accepted PY - 2018/1/15/pubmed PY - 2018/9/8/medline PY - 2018/1/15/entrez KW - Hypothalamic-pituitary-thyroid axis KW - Statins KW - Thyroiditis KW - Vitamin D SP - 93 EP - 97 JF - Pharmacological reports : PR JO - Pharmacol Rep VL - 70 IS - 1 N2 - BACKGROUND: Vitamin D preparations reduce titers of thyroid antibodies in women with autoimmune thyroiditis. The same effect was induced by high-dose, but not moderate-dose-, statin therapy. No previous study has investigated the impact of concomitant treatment with a statin and vitamin D on thyroid autoimmunity. METHODS: The study included three matched groups of women with Hashimoto's thyroiditis and low vitamin D status. Groups B (n=19) and C (n=20) were treated with vitamin D (2000 IU daily). Because of coexistent hypercholesterolemia, groups A (n=18) and B received simvastatin (40mg daily). Plasma lipids, serum levels of thyrotropin, free thyroid hormones and 25-hydroxyvitamin D, as well as titers of thyroid peroxidase and thyroglobulin antibodies were measured at the beginning of the study and 6 months later. RESULTS: At baseline, 25-hydroxyvitamin D levels inversely correlated with titers of thyroid antibodies. In groups A and B, simvastatin reduced plasma levels of total and LDL cholesterol. Simvastatin produced no effect on thyroid antibody titers. Vitamin D decreased titers of thyroid peroxidase antibodies, as well as tended to decrease titers of thyroglobulin antibodies. Simvastatin-vitamin D combination therapy reduced serum titers of thyroid peroxidase and thyroglobulin antibodies and this effect was stronger than the effect of simvastatin and vitamin D administered alone. Treatment-induced changes in thyroid antibody titers correlated with baseline antibody titers, baseline levels of 25-hydroxyvitamin and treatment-induced changes in 25-hydroxyvitamin. CONCLUSIONS: The obtained results indicate that simvastatin may potentiate the impact of vitamin D on thyroid autoimmunity in vitamin D-deficient women with Hashimoto's thyroiditis. SN - 1734-1140 UR - https://www.unboundmedicine.com/medline/citation/29331793/Moderate_dose_simvastatin_therapy_potentiates_the_effect_of_vitamin_D_on_thyroid_autoimmunity_in_levothyroxine_treated_women_with_Hashimoto's_thyroiditis_and_vitamin_D_insufficiency_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1734-1140(17)30443-7 DB - PRIME DP - Unbound Medicine ER -