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Is the Atopy Patch Test Reliable in the Evaluation of Food Allergy-Related Atopic Dermatitis?
Int Arch Allergy Immunol 2018; 175(1-2):85-90IA

Abstract

BACKGROUND

Aeroallergens and food allergens are found to be relevant in atopic dermatitis. The atopy patch test (APT) can help to detect food allergies in children with atopic dermatitis. This study evaluates if the APT is a valuable tool in the diagnostic workup of children with food allergy-related atopic dermatitis.

METHODS

42 children between 6 months and 12 years of age were selected at the Mofid Children Hospital. Atopic dermatitis was diagnosed, and the severity of the disease was determined. At the test visit, the patients underwent a skin prick test (SPT), APT, and serum IgE level measurement for cow's milk, egg yolk, egg white, wheat, and soy.

RESULTS

We found a sensitivity of 91.7%, a specificity of 72.7%, a positive predictive value (PPV) of 88%, a negative predictive value (NPV) of 80%, and an accuracy of 85.7% for APT performed for cow's milk. APT performed for egg yolk had a sensitivity and a NPV of 100%, while the same parameters obtained with egg white were 84.2 and 75%, respectively. The sensitivity, specificity, and NPV of the APT for wheat were 100, 75, and 100%, respectively. The sensitivity, PPV, and NPV of the APT for soy were 87.5, 70, and 87.5%, respectively.

CONCLUSIONS

Our data demonstrate that the APT is a reliable diagnostic tool to evaluate suspected food allergy-related skin symptoms in childhood and infancy.

Authors+Show Affiliations

Department of Immunology and Allergy, Mofid Children Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

29332097

Citation

Mansouri, Mahboubeh, et al. "Is the Atopy Patch Test Reliable in the Evaluation of Food Allergy-Related Atopic Dermatitis?" International Archives of Allergy and Immunology, vol. 175, no. 1-2, 2018, pp. 85-90.
Mansouri M, Rafiee E, Darougar S, et al. Is the Atopy Patch Test Reliable in the Evaluation of Food Allergy-Related Atopic Dermatitis? Int Arch Allergy Immunol. 2018;175(1-2):85-90.
Mansouri, M., Rafiee, E., Darougar, S., Mesdaghi, M., & Chavoshzadeh, Z. (2018). Is the Atopy Patch Test Reliable in the Evaluation of Food Allergy-Related Atopic Dermatitis? International Archives of Allergy and Immunology, 175(1-2), pp. 85-90. doi:10.1159/000485126.
Mansouri M, et al. Is the Atopy Patch Test Reliable in the Evaluation of Food Allergy-Related Atopic Dermatitis. Int Arch Allergy Immunol. 2018;175(1-2):85-90. PubMed PMID: 29332097.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Is the Atopy Patch Test Reliable in the Evaluation of Food Allergy-Related Atopic Dermatitis? AU - Mansouri,Mahboubeh, AU - Rafiee,Elham, AU - Darougar,Sepideh, AU - Mesdaghi,Mehrnaz, AU - Chavoshzadeh,Zahra, Y1 - 2018/01/13/ PY - 2017/04/13/received PY - 2017/11/08/accepted PY - 2018/1/15/pubmed PY - 2018/4/3/medline PY - 2018/1/15/entrez KW - Atopic dermatitis KW - Food allergy KW - Patch test SP - 85 EP - 90 JF - International archives of allergy and immunology JO - Int. Arch. Allergy Immunol. VL - 175 IS - 1-2 N2 - BACKGROUND: Aeroallergens and food allergens are found to be relevant in atopic dermatitis. The atopy patch test (APT) can help to detect food allergies in children with atopic dermatitis. This study evaluates if the APT is a valuable tool in the diagnostic workup of children with food allergy-related atopic dermatitis. METHODS: 42 children between 6 months and 12 years of age were selected at the Mofid Children Hospital. Atopic dermatitis was diagnosed, and the severity of the disease was determined. At the test visit, the patients underwent a skin prick test (SPT), APT, and serum IgE level measurement for cow's milk, egg yolk, egg white, wheat, and soy. RESULTS: We found a sensitivity of 91.7%, a specificity of 72.7%, a positive predictive value (PPV) of 88%, a negative predictive value (NPV) of 80%, and an accuracy of 85.7% for APT performed for cow's milk. APT performed for egg yolk had a sensitivity and a NPV of 100%, while the same parameters obtained with egg white were 84.2 and 75%, respectively. The sensitivity, specificity, and NPV of the APT for wheat were 100, 75, and 100%, respectively. The sensitivity, PPV, and NPV of the APT for soy were 87.5, 70, and 87.5%, respectively. CONCLUSIONS: Our data demonstrate that the APT is a reliable diagnostic tool to evaluate suspected food allergy-related skin symptoms in childhood and infancy. SN - 1423-0097 UR - https://www.unboundmedicine.com/medline/citation/29332097/Is_the_Atopy_Patch_Test_Reliable_in_the_Evaluation_of_Food_Allergy_Related_Atopic_Dermatitis L2 - https://www.karger.com?DOI=10.1159/000485126 DB - PRIME DP - Unbound Medicine ER -