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Antifungal activity of phenolic monoterpenes and structure-related compounds against plant pathogenic fungi.
Nat Prod Res. 2019 May; 33(10):1423-1430.NP

Abstract

The aim of this work is to explore the possibility of using the phenolic monoterpenes (PMs) as leading compounds with antifungal activity against plant disease. The in vitro antifungal activities of carvacrol and thymol against seven kinds of plant pathogenic fungi were evaluated on mycelium growth rate method, and the results showed that carvacrol and thymol exhibited broad spectrum antifungal activity. Structure requirement for the antifungal activity of PMs was also investigated. The preliminary conclusion was that phenolic hydroxyl and monoterpene were basic structures for the antifungal activity of PMs, and the position of phenolic hydroxyl showed less effect. Ester derivatives of carvacrol and thymol were more effective than carvacrol and thymol against plant pathogenic fungi. We suggested that carvacrol, thymol and their ester derivatives could potentially be used as new fungicide leading compounds.

Authors+Show Affiliations

a State Key Laboratory for Conservation and Utilization of Bio-Resources in Yunnan , Yunnan Agricultural University , Kunming , China.a State Key Laboratory for Conservation and Utilization of Bio-Resources in Yunnan , Yunnan Agricultural University , Kunming , China.a State Key Laboratory for Conservation and Utilization of Bio-Resources in Yunnan , Yunnan Agricultural University , Kunming , China.a State Key Laboratory for Conservation and Utilization of Bio-Resources in Yunnan , Yunnan Agricultural University , Kunming , China.a State Key Laboratory for Conservation and Utilization of Bio-Resources in Yunnan , Yunnan Agricultural University , Kunming , China.a State Key Laboratory for Conservation and Utilization of Bio-Resources in Yunnan , Yunnan Agricultural University , Kunming , China.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

29334264

Citation

Wang, Kaibo, et al. "Antifungal Activity of Phenolic Monoterpenes and Structure-related Compounds Against Plant Pathogenic Fungi." Natural Product Research, vol. 33, no. 10, 2019, pp. 1423-1430.
Wang K, Jiang S, Pu T, et al. Antifungal activity of phenolic monoterpenes and structure-related compounds against plant pathogenic fungi. Nat Prod Res. 2019;33(10):1423-1430.
Wang, K., Jiang, S., Pu, T., Fan, L., Su, F., & Ye, M. (2019). Antifungal activity of phenolic monoterpenes and structure-related compounds against plant pathogenic fungi. Natural Product Research, 33(10), 1423-1430. https://doi.org/10.1080/14786419.2017.1419232
Wang K, et al. Antifungal Activity of Phenolic Monoterpenes and Structure-related Compounds Against Plant Pathogenic Fungi. Nat Prod Res. 2019;33(10):1423-1430. PubMed PMID: 29334264.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Antifungal activity of phenolic monoterpenes and structure-related compounds against plant pathogenic fungi. AU - Wang,Kaibo, AU - Jiang,Shanshan, AU - Pu,Te, AU - Fan,Liming, AU - Su,Fawu, AU - Ye,Min, Y1 - 2018/01/15/ PY - 2018/1/16/pubmed PY - 2019/8/20/medline PY - 2018/1/16/entrez KW - Antifungal activity KW - Carvacrol KW - Phenolic monoterpenes KW - Structure requirement KW - Thymol SP - 1423 EP - 1430 JF - Natural product research JO - Nat. Prod. Res. VL - 33 IS - 10 N2 - The aim of this work is to explore the possibility of using the phenolic monoterpenes (PMs) as leading compounds with antifungal activity against plant disease. The in vitro antifungal activities of carvacrol and thymol against seven kinds of plant pathogenic fungi were evaluated on mycelium growth rate method, and the results showed that carvacrol and thymol exhibited broad spectrum antifungal activity. Structure requirement for the antifungal activity of PMs was also investigated. The preliminary conclusion was that phenolic hydroxyl and monoterpene were basic structures for the antifungal activity of PMs, and the position of phenolic hydroxyl showed less effect. Ester derivatives of carvacrol and thymol were more effective than carvacrol and thymol against plant pathogenic fungi. We suggested that carvacrol, thymol and their ester derivatives could potentially be used as new fungicide leading compounds. SN - 1478-6427 UR - https://www.unboundmedicine.com/medline/citation/29334264/Antifungal_activity_of_phenolic_monoterpenes_and_structure_related_compounds_against_plant_pathogenic_fungi_ L2 - http://www.tandfonline.com/doi/full/10.1080/14786419.2017.1419232 DB - PRIME DP - Unbound Medicine ER -