Tags

Type your tag names separated by a space and hit enter

Supplementation with Curcuma longa Reverses Neurotoxic and Behavioral Damage in Models of Alzheimer's Disease: A Systematic Review.
Curr Neuropharmacol. 2019; 17(5):406-421.CN

Abstract

BACKGROUND

The formation of senile plaques and neurofibrillary tangles of the tau protein are the main pathological mechanism of Alzheimer's disease (AD). Current therapies for AD offer discrete benefits to the clinical symptoms and do not prevent the continuing degeneration of neuronal cells. Therefore, novel therapeutic strategies have long been investigated, where curcumin (Curcuma longa) has shown some properties that can prevent the deleterious processes involved in neurodegenerative diseases.

OBJECTIVE

The aim of the present work is to review studies that addressed the effects of curcumin in experimental models (in vivo and in vitro) for AD.

METHOD

This study is a systematic review conducted between January and June 2017, in which a consultation of scientific articles from indexed periodicals was carried out in Science Direct, United States National Library of Medicine (PubMed), Cochrane Library and Scielo databases, using the following descriptors: "Curcuma longa", "Curcumin" and "Alzheimer's disease".

RESULTS

A total of 32 studies were analyzed, which indicated that curcumin supplementation reverses neurotoxic and behavioral damages in both in vivo and in vitro models of AD.

CONCLUSION

The administration of curcumin in experimental models seems to be a promising approach in AD, even though it is suggested that additional studies must be conducted using distinct doses and through other routes of administration.

Links

PMC Free PDF

Authors+Show Affiliations

da Costa IM
Laboratory of Experimental Neurology, Department of Biomedical Sciences, Faculty of Health Sciences, University of the State of Rio Grande do Norte, Mossoro/RN, Brazil. Post graduate in Prescription of Herbal Medicines, Clinical and Sports Nutritional Supplementation, Estácio de Sá University, São Paulo/SP, Brazil.
Freire MAM
Laboratory of Experimental Neurology, Department of Biomedical Sciences, Faculty of Health Sciences, University of the State of Rio Grande do Norte, Mossoro/RN, Brazil.
de Paiva Cavalcanti JRL
Laboratory of Experimental Neurology, Department of Biomedical Sciences, Faculty of Health Sciences, University of the State of Rio Grande do Norte, Mossoro/RN, Brazil.
de Araújo DP
Laboratory of Experimental Neurology, Department of Biomedical Sciences, Faculty of Health Sciences, University of the State of Rio Grande do Norte, Mossoro/RN, Brazil.
Norrara B
Laboratory of Experimental Neurology, Department of Biomedical Sciences, Faculty of Health Sciences, University of the State of Rio Grande do Norte, Mossoro/RN, Brazil.
Moreira Rosa IMM
Laboratory of Experimental Neurology, Department of Biomedical Sciences, Faculty of Health Sciences, University of the State of Rio Grande do Norte, Mossoro/RN, Brazil.
de Azevedo EP
Post Graduation Program in Biotechnology, Health School, Potiguar University (UnP), Natal/RN, Brazil.
do Rego ACM
Post Graduation Program in Biotechnology, Health School, Potiguar University (UnP), Natal/RN, Brazil.
Filho IA
Post Graduation Program in Biotechnology, Health School, Potiguar University (UnP), Natal/RN, Brazil.
Guzen FP
Laboratory of Experimental Neurology, Department of Biomedical Sciences, Faculty of Health Sciences, University of the State of Rio Grande do Norte, Mossoro/RN, Brazil. Post Graduation Program in Biotechnology, Health School, Potiguar University (UnP), Natal/RN, Brazil.

MeSH

Alzheimer DiseaseAmyloid beta-PeptidesAnimalsCurcumaCurcuminDietary SupplementsHumansNeurofibrillary TanglesNeuroprotective AgentsPlant ExtractsRandomized Controlled Trials as Topic

Pub Type(s)

Journal Article
Systematic Review

Language

eng

PubMed ID

29338678

Citation

da Costa, Ianara Mendonça, et al. "Supplementation With Curcuma Longa Reverses Neurotoxic and Behavioral Damage in Models of Alzheimer's Disease: a Systematic Review." Current Neuropharmacology, vol. 17, no. 5, 2019, pp. 406-421.
da Costa IM, Freire MAM, de Paiva Cavalcanti JRL, et al. Supplementation with Curcuma longa Reverses Neurotoxic and Behavioral Damage in Models of Alzheimer's Disease: A Systematic Review. Curr Neuropharmacol. 2019;17(5):406-421.
da Costa, I. M., Freire, M. A. M., de Paiva Cavalcanti, J. R. L., de Araújo, D. P., Norrara, B., Moreira Rosa, I. M. M., de Azevedo, E. P., do Rego, A. C. M., Filho, I. A., & Guzen, F. P. (2019). Supplementation with Curcuma longa Reverses Neurotoxic and Behavioral Damage in Models of Alzheimer's Disease: A Systematic Review. Current Neuropharmacology, 17(5), 406-421. https://doi.org/10.2174/0929867325666180117112610
da Costa IM, et al. Supplementation With Curcuma Longa Reverses Neurotoxic and Behavioral Damage in Models of Alzheimer's Disease: a Systematic Review. Curr Neuropharmacol. 2019;17(5):406-421. PubMed PMID: 29338678.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Supplementation with Curcuma longa Reverses Neurotoxic and Behavioral Damage in Models of Alzheimer's Disease: A Systematic Review. AU - da Costa,Ianara Mendonça, AU - Freire,Marco Aurelio de Moura, AU - de Paiva Cavalcanti,José Rodolfo Lopes, AU - de Araújo,Dayane Pessoa, AU - Norrara,Bianca, AU - Moreira Rosa,Isleânia Maria Marques, AU - de Azevedo,Eduardo Pereira, AU - do Rego,Amália Cinthia Meneses, AU - Filho,Irami Araújo, AU - Guzen,Fausto Pierdoná, PY - 2017/11/06/received PY - 2018/01/03/revised PY - 2018/01/11/accepted PY - 2018/1/18/pubmed PY - 2019/8/15/medline PY - 2018/1/18/entrez KW - Alzheimer's disease KW - Aβ aggregation KW - brain KW - curcumin KW - oxidative stress KW - therapeutics. SP - 406 EP - 421 JF - Current neuropharmacology JO - Curr Neuropharmacol VL - 17 IS - 5 N2 - BACKGROUND: The formation of senile plaques and neurofibrillary tangles of the tau protein are the main pathological mechanism of Alzheimer's disease (AD). Current therapies for AD offer discrete benefits to the clinical symptoms and do not prevent the continuing degeneration of neuronal cells. Therefore, novel therapeutic strategies have long been investigated, where curcumin (Curcuma longa) has shown some properties that can prevent the deleterious processes involved in neurodegenerative diseases. OBJECTIVE: The aim of the present work is to review studies that addressed the effects of curcumin in experimental models (in vivo and in vitro) for AD. METHOD: This study is a systematic review conducted between January and June 2017, in which a consultation of scientific articles from indexed periodicals was carried out in Science Direct, United States National Library of Medicine (PubMed), Cochrane Library and Scielo databases, using the following descriptors: "Curcuma longa", "Curcumin" and "Alzheimer's disease". RESULTS: A total of 32 studies were analyzed, which indicated that curcumin supplementation reverses neurotoxic and behavioral damages in both in vivo and in vitro models of AD. CONCLUSION: The administration of curcumin in experimental models seems to be a promising approach in AD, even though it is suggested that additional studies must be conducted using distinct doses and through other routes of administration. SN - 1875-6190 UR - https://www.unboundmedicine.com/medline/citation/29338678/Supplementation_with_Curcuma_longa_Reverses_Neurotoxic_and_Behavioral_Damage_in_Models_of_Alzheimer's_Disease:_A_Systematic_Review_ DB - PRIME DP - Unbound Medicine ER -