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Corneal Collagen Crosslinking Combined with Phototherapeutic Keratectomy and Photorefractive Keratectomy for Corneal Ectasia after Laser in situ Keratomileusis.
Ophthalmic Res. 2018; 59(3):135-141.OR

Abstract

PURPOSE

The aim of this study was to analyze the effects of corneal crosslinking (CXL) combined with phototherapeutic keratectomy (PTK) and photorefractive keratectomy (PRK) in halting the progression and improving the visual function of corneal ectasia after laser in situ keratomileusis (LASIK).

METHODS

PTK-PRK-CXL was performed on 14 eyes of 14 patients who developed corneal ectasia after LASIK. The visual acuity, spherical refraction and cylinder, corneal topography indices, thinnest corneal thickness (TCT), and endothelial cell count were evaluated at baseline and at 1, 3, 6, and 12 months postoperatively.

RESULTS

The mean uncorrected visual acuity improved significantly from 0.64 ± 0.36 logMAR preoperatively to 0.19 ± 0.12 logMAR at 12 months of follow-up (p < 0.001), while the mean best corrected visual acuity improved from 0.21 ± 0.14 logMAR at baseline to 0.04 ± 0.10 logMAR at 12 months postoperatively (p < 0.001). A significant decrease was observed in Kmax and Kmean values from 52.51 ± 6.74 and 43.55 ± 3.37 D at baseline to 45.72 ± 5.18 (p < 0.001) and 40.60 ± 3.05 D (p < 0.001) at the 1-year follow-up. The mean TCT decreased significantly from 419.07 ± 36.56 µm before treatment to 320.93 ± 39.78 µm at 12 months of follow-up (p < 0.001), and there was no significant endothelial cell loss (p > 0.05) beyond 6 months after treatment.

CONCLUSION

PTK-PRK-CXL is a promising procedure to halt the progression of post-LASIK keratectasia with significant visual quality improvement.

Authors+Show Affiliations

Department of Ophthalmology, Shandong Provincial Hospital Affiliated to Shandong University, Jinan, China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

29339637

Citation

Zhu, Wei, et al. "Corneal Collagen Crosslinking Combined With Phototherapeutic Keratectomy and Photorefractive Keratectomy for Corneal Ectasia After Laser in Situ Keratomileusis." Ophthalmic Research, vol. 59, no. 3, 2018, pp. 135-141.
Zhu W, Han Y, Cui C, et al. Corneal Collagen Crosslinking Combined with Phototherapeutic Keratectomy and Photorefractive Keratectomy for Corneal Ectasia after Laser in situ Keratomileusis. Ophthalmic Res. 2018;59(3):135-141.
Zhu, W., Han, Y., Cui, C., Xu, W., Wang, X., Dou, X., Xu, L., Xu, Y., & Mu, G. (2018). Corneal Collagen Crosslinking Combined with Phototherapeutic Keratectomy and Photorefractive Keratectomy for Corneal Ectasia after Laser in situ Keratomileusis. Ophthalmic Research, 59(3), 135-141. https://doi.org/10.1159/000480242
Zhu W, et al. Corneal Collagen Crosslinking Combined With Phototherapeutic Keratectomy and Photorefractive Keratectomy for Corneal Ectasia After Laser in Situ Keratomileusis. Ophthalmic Res. 2018;59(3):135-141. PubMed PMID: 29339637.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Corneal Collagen Crosslinking Combined with Phototherapeutic Keratectomy and Photorefractive Keratectomy for Corneal Ectasia after Laser in situ Keratomileusis. AU - Zhu,Wei, AU - Han,Yunfei, AU - Cui,Changxia, AU - Xu,Wenwen, AU - Wang,Xuan, AU - Dou,Xiaoxiao, AU - Xu,Linlin, AU - Xu,Yanyun, AU - Mu,Guoying, Y1 - 2018/01/17/ PY - 2017/01/18/received PY - 2017/08/10/accepted PY - 2018/1/18/pubmed PY - 2018/6/12/medline PY - 2018/1/18/entrez KW - Crosslinking KW - Ectasia KW - Laser in situ keratomileusis KW - Photorefractive keratectomy KW - Phototherapeutic keratectomy SP - 135 EP - 141 JF - Ophthalmic research JO - Ophthalmic Res VL - 59 IS - 3 N2 - PURPOSE: The aim of this study was to analyze the effects of corneal crosslinking (CXL) combined with phototherapeutic keratectomy (PTK) and photorefractive keratectomy (PRK) in halting the progression and improving the visual function of corneal ectasia after laser in situ keratomileusis (LASIK). METHODS: PTK-PRK-CXL was performed on 14 eyes of 14 patients who developed corneal ectasia after LASIK. The visual acuity, spherical refraction and cylinder, corneal topography indices, thinnest corneal thickness (TCT), and endothelial cell count were evaluated at baseline and at 1, 3, 6, and 12 months postoperatively. RESULTS: The mean uncorrected visual acuity improved significantly from 0.64 ± 0.36 logMAR preoperatively to 0.19 ± 0.12 logMAR at 12 months of follow-up (p < 0.001), while the mean best corrected visual acuity improved from 0.21 ± 0.14 logMAR at baseline to 0.04 ± 0.10 logMAR at 12 months postoperatively (p < 0.001). A significant decrease was observed in Kmax and Kmean values from 52.51 ± 6.74 and 43.55 ± 3.37 D at baseline to 45.72 ± 5.18 (p < 0.001) and 40.60 ± 3.05 D (p < 0.001) at the 1-year follow-up. The mean TCT decreased significantly from 419.07 ± 36.56 µm before treatment to 320.93 ± 39.78 µm at 12 months of follow-up (p < 0.001), and there was no significant endothelial cell loss (p > 0.05) beyond 6 months after treatment. CONCLUSION: PTK-PRK-CXL is a promising procedure to halt the progression of post-LASIK keratectasia with significant visual quality improvement. SN - 1423-0259 UR - https://www.unboundmedicine.com/medline/citation/29339637/Corneal_Collagen_Crosslinking_Combined_with_Phototherapeutic_Keratectomy_and_Photorefractive_Keratectomy_for_Corneal_Ectasia_after_Laser_in_situ_Keratomileusis_ L2 - https://www.karger.com?DOI=10.1159/000480242 DB - PRIME DP - Unbound Medicine ER -