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Tadalafil Improves Symptoms, Erectile Function and Quality of Life in Patients with Lower Urinary Tract Symptoms Suggestive of Benign Prostatic Hyperplasia (KYU-PRO Study).
Low Urin Tract Symptoms. 2018 Jan; 10(1):76-83.LU

Abstract

OBJECTIVES

Effect of tadalafil on lower urinary tract symptoms (LUTS), erectile function and quality of life (QoL) were prospectively evaluated in patients with benign prostatic hyperplasia (BPH) at multicenter.

METHODS

Eligible men were ≥40 years who had no treatment with alpha-blocker for BPH, with total International Prostate Symptom Score (IPSS) ≥8, IPSS-QOL ≥2 and prostate volume ≥20 mL. Data were collected on age, body mass index (BMI), and prostate specific antigen (PSA). Patients were asked to complete a self-reported questionnaire regarding the IPSS, Overactive Bladder Symptom Score (OABSS), International Index of Erectile Function 5 (IIEF5), and Medical Outcome Study 8-Item Short-Form Health Survey (SF-8). These measures were assessed at baseline, 4-, 8-, 12-week of tadalafil treatment. In addition, uroflowmetry was also performed at baseline, and 12-week end point visit.

RESULTS

Thirty five patients with mean age 67.3 years, mean BMI 23.6 kg/m2 , mean prostate volume 36 mL, and mean PSA 3.4 ng/mL were enrolled. Treatment with tadalafil significantly improved IPSS total score, IPSS voiding subscore, IPSS storage subscore, OABSS and IPSS-QoL score after 4 weeks and these improvements were maintained for 12-week treatment period. IIEF5 score and general health in SF-8 are significantly improved with the treatment of tadalafil. However, maximum flow rate and postvoiding residual volume were not significantly changed. There were not any serious adverse events.

CONCLUSIONS

These results indicate that tadalafil 5 mg once daily would be effective and well tolerated treatment in Japanese men with BPH-LUTS.

Authors+Show Affiliations

Department of Urology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.Department of Urology, Graduate School of Medicine, University of the Ryukyus, Okinawa, Japan.Department of Urology, University of Occupational and Environmental Health, Kitakyushu, Japan.Department of Urology, Oita University Faculty of Medicine, Oita, Japan.Department of Urology, Takayama Hospital, Fukuoka, Japan.Department of Urology, Kano Hospital, Fukuoka, Japan.Department of Urology, Graduate School of Medicine, University of the Ryukyus, Okinawa, Japan.Department of Urology, Graduate School of Medicine, University of the Ryukyus, Okinawa, Japan.Department of Urology, University of Occupational and Environmental Health, Kitakyushu, Japan.Department of Urology, Oita University Faculty of Medicine, Oita, Japan.Department of Urology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.

Pub Type(s)

Journal Article
Multicenter Study

Language

eng

PubMed ID

29341501

Citation

Takahashi, Ryosuke, et al. "Tadalafil Improves Symptoms, Erectile Function and Quality of Life in Patients With Lower Urinary Tract Symptoms Suggestive of Benign Prostatic Hyperplasia (KYU-PRO Study)." Lower Urinary Tract Symptoms, vol. 10, no. 1, 2018, pp. 76-83.
Takahashi R, Miyazato M, Nishii H, et al. Tadalafil Improves Symptoms, Erectile Function and Quality of Life in Patients with Lower Urinary Tract Symptoms Suggestive of Benign Prostatic Hyperplasia (KYU-PRO Study). Low Urin Tract Symptoms. 2018;10(1):76-83.
Takahashi, R., Miyazato, M., Nishii, H., Sumino, Y., Takayama, K., Onzuka, M., Oshiro, T., Saito, S., Fujimoto, N., Mimata, H., & Eto, M. (2018). Tadalafil Improves Symptoms, Erectile Function and Quality of Life in Patients with Lower Urinary Tract Symptoms Suggestive of Benign Prostatic Hyperplasia (KYU-PRO Study). Lower Urinary Tract Symptoms, 10(1), 76-83. https://doi.org/10.1111/luts.12143
Takahashi R, et al. Tadalafil Improves Symptoms, Erectile Function and Quality of Life in Patients With Lower Urinary Tract Symptoms Suggestive of Benign Prostatic Hyperplasia (KYU-PRO Study). Low Urin Tract Symptoms. 2018;10(1):76-83. PubMed PMID: 29341501.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Tadalafil Improves Symptoms, Erectile Function and Quality of Life in Patients with Lower Urinary Tract Symptoms Suggestive of Benign Prostatic Hyperplasia (KYU-PRO Study). AU - Takahashi,Ryosuke, AU - Miyazato,Minoru, AU - Nishii,Hisae, AU - Sumino,Yasuhiro, AU - Takayama,Kazuo, AU - Onzuka,Masako, AU - Oshiro,Takuma, AU - Saito,Seiichi, AU - Fujimoto,Naohiro, AU - Mimata,Hiromitsu, AU - Eto,Masatoshi, Y1 - 2016/11/05/ PY - 2016/02/02/received PY - 2016/04/28/revised PY - 2016/05/09/accepted PY - 2018/1/18/entrez PY - 2018/1/18/pubmed PY - 2018/8/22/medline KW - benign prostatic hyperplasia KW - erectile function KW - lower urinary tract symptoms KW - phosphodiesterase 5 inhibitor KW - quality of life SP - 76 EP - 83 JF - Lower urinary tract symptoms JO - Low Urin Tract Symptoms VL - 10 IS - 1 N2 - OBJECTIVES: Effect of tadalafil on lower urinary tract symptoms (LUTS), erectile function and quality of life (QoL) were prospectively evaluated in patients with benign prostatic hyperplasia (BPH) at multicenter. METHODS: Eligible men were ≥40 years who had no treatment with alpha-blocker for BPH, with total International Prostate Symptom Score (IPSS) ≥8, IPSS-QOL ≥2 and prostate volume ≥20 mL. Data were collected on age, body mass index (BMI), and prostate specific antigen (PSA). Patients were asked to complete a self-reported questionnaire regarding the IPSS, Overactive Bladder Symptom Score (OABSS), International Index of Erectile Function 5 (IIEF5), and Medical Outcome Study 8-Item Short-Form Health Survey (SF-8). These measures were assessed at baseline, 4-, 8-, 12-week of tadalafil treatment. In addition, uroflowmetry was also performed at baseline, and 12-week end point visit. RESULTS: Thirty five patients with mean age 67.3 years, mean BMI 23.6 kg/m2 , mean prostate volume 36 mL, and mean PSA 3.4 ng/mL were enrolled. Treatment with tadalafil significantly improved IPSS total score, IPSS voiding subscore, IPSS storage subscore, OABSS and IPSS-QoL score after 4 weeks and these improvements were maintained for 12-week treatment period. IIEF5 score and general health in SF-8 are significantly improved with the treatment of tadalafil. However, maximum flow rate and postvoiding residual volume were not significantly changed. There were not any serious adverse events. CONCLUSIONS: These results indicate that tadalafil 5 mg once daily would be effective and well tolerated treatment in Japanese men with BPH-LUTS. SN - 1757-5672 UR - https://www.unboundmedicine.com/medline/citation/29341501/Tadalafil_Improves_Symptoms_Erectile_Function_and_Quality_of_Life_in_Patients_with_Lower_Urinary_Tract_Symptoms_Suggestive_of_Benign_Prostatic_Hyperplasia__KYU_PRO_Study__ L2 - https://doi.org/10.1111/luts.12143 DB - PRIME DP - Unbound Medicine ER -