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Portulaca oleracea L. Extract Enhances Glucose Uptake by Stimulating GLUT4 Translocation to the Plasma Membrane in 3T3-L1 Adipocytes.
J Med Food. 2018 May; 21(5):462-468.JM

Abstract

This study investigated the effects of Portulaca oleracea L. extract on glucose uptake in 3T3-L1 adipocytes. P. oleracea extract (POE) markedly enhanced glucose uptake, which was caused by increased GLUT4 expression at the plasma membrane (PM) in 3T3-L1 adipocytes. This increase in PM-GLUT4 expression was associated with insulin receptor substrate-1 (IRS-1) phosphorylation, phosphatidylinositol 3-kinase (PI3K) activation, and Akt phosphorylation, and finally, enhanced intracellular glucose uptake. POE was not associated with protein kinase C (PKC)λ/ζ phosphorylation in the insulin signaling pathway, but did promote 5'-AMP-activated kinase (AMPK) phosphorylation. Increased glucose uptake through POE was inhibited through treating with the PI3K inhibitor or AMPK inhibitor in 3T3-L1 adipocytes. This result suggested that POE may enhance glucose uptake by stimulating GLUT4 translocation to the PM through activating the PI3K and AMPK pathway in 3T3-L1 adipocytes.

Authors+Show Affiliations

Department of Food Science and Nutrition, Pusan National University , Busan, Korea.Department of Food Science and Nutrition, Pusan National University , Busan, Korea.Department of Food Science and Nutrition, Pusan National University , Busan, Korea.Department of Food Science and Nutrition, Pusan National University , Busan, Korea.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

29341802

Citation

Park, Jae Eun, et al. "Portulaca Oleracea L. Extract Enhances Glucose Uptake By Stimulating GLUT4 Translocation to the Plasma Membrane in 3T3-L1 Adipocytes." Journal of Medicinal Food, vol. 21, no. 5, 2018, pp. 462-468.
Park JE, Lee JS, Lee HA, et al. Portulaca oleracea L. Extract Enhances Glucose Uptake by Stimulating GLUT4 Translocation to the Plasma Membrane in 3T3-L1 Adipocytes. J Med Food. 2018;21(5):462-468.
Park, J. E., Lee, J. S., Lee, H. A., & Han, J. S. (2018). Portulaca oleracea L. Extract Enhances Glucose Uptake by Stimulating GLUT4 Translocation to the Plasma Membrane in 3T3-L1 Adipocytes. Journal of Medicinal Food, 21(5), 462-468. https://doi.org/10.1089/jmf.2017.4098
Park JE, et al. Portulaca Oleracea L. Extract Enhances Glucose Uptake By Stimulating GLUT4 Translocation to the Plasma Membrane in 3T3-L1 Adipocytes. J Med Food. 2018;21(5):462-468. PubMed PMID: 29341802.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Portulaca oleracea L. Extract Enhances Glucose Uptake by Stimulating GLUT4 Translocation to the Plasma Membrane in 3T3-L1 Adipocytes. AU - Park,Jae Eun, AU - Lee,Ji Soo, AU - Lee,Hyun Ah, AU - Han,Ji Sook, Y1 - 2018/01/17/ PY - 2018/1/18/pubmed PY - 2018/10/30/medline PY - 2018/1/18/entrez KW - 3T3-L1 adipocytes KW - GLUT4 translocation KW - Portulaca oleracea KW - glucose uptake SP - 462 EP - 468 JF - Journal of medicinal food JO - J Med Food VL - 21 IS - 5 N2 - This study investigated the effects of Portulaca oleracea L. extract on glucose uptake in 3T3-L1 adipocytes. P. oleracea extract (POE) markedly enhanced glucose uptake, which was caused by increased GLUT4 expression at the plasma membrane (PM) in 3T3-L1 adipocytes. This increase in PM-GLUT4 expression was associated with insulin receptor substrate-1 (IRS-1) phosphorylation, phosphatidylinositol 3-kinase (PI3K) activation, and Akt phosphorylation, and finally, enhanced intracellular glucose uptake. POE was not associated with protein kinase C (PKC)λ/ζ phosphorylation in the insulin signaling pathway, but did promote 5'-AMP-activated kinase (AMPK) phosphorylation. Increased glucose uptake through POE was inhibited through treating with the PI3K inhibitor or AMPK inhibitor in 3T3-L1 adipocytes. This result suggested that POE may enhance glucose uptake by stimulating GLUT4 translocation to the PM through activating the PI3K and AMPK pathway in 3T3-L1 adipocytes. SN - 1557-7600 UR - https://www.unboundmedicine.com/medline/citation/29341802/Portulaca_oleracea_L__Extract_Enhances_Glucose_Uptake_by_Stimulating_GLUT4_Translocation_to_the_Plasma_Membrane_in_3T3_L1_Adipocytes_ L2 - https://www.liebertpub.com/doi/full/10.1089/jmf.2017.4098?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -