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Associations between Zinc Deficiency and Metabolic Abnormalities in Patients with Chronic Liver Disease.
Nutrients 2018; 10(1)N

Abstract

Zinc (Zn) is an essential trace element which has favorable antioxidant, anti-inflammatory, and apoptotic effects. The liver mainly plays a crucial role in maintaining systemic Zn homeostasis. Therefore, the occurrence of chronic liver diseases, such as chronic hepatitis, liver cirrhosis, or fatty liver, results in the impairment of Zn metabolism, and subsequently Zn deficiency. Zn deficiency causes plenty of metabolic abnormalities, including insulin resistance, hepatic steatosis and hepatic encephalopathy. Inversely, metabolic abnormalities like hypoalbuminemia in patients with liver cirrhosis often result in Zn deficiency. Recent studies have revealed the putative mechanisms by which Zn deficiency evokes a variety of metabolic abnormalities in chronic liver disease. Zn supplementation has shown beneficial effects on such metabolic abnormalities in experimental models and actual patients with chronic liver disease. This review summarizes the pathogenesis of metabolic abnormalities deriving from Zn deficiency and the favorable effects of Zn administration in patients with chronic liver disease. In addition, we also highlight the interactions between Zn and other trace elements, vitamins, amino acids, or hormones in such patients.

Authors+Show Affiliations

Department of Medical Technology, Kagawa Prefectural University of Health Sciences, 281-1, Hara, Mure-Cho, Takamatsu, Kagawa 761-0123, Japan. himoto@chs.pref.kagawa.jp.Department of Gastroenterology and Neurology, Kagawa University School of Medicine, Kagawa 761-0123, Japan. tmasaki@med.kagawa-u.ac.jp.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

29342898

Citation

Himoto, Takashi, and Tsutomu Masaki. "Associations Between Zinc Deficiency and Metabolic Abnormalities in Patients With Chronic Liver Disease." Nutrients, vol. 10, no. 1, 2018.
Himoto T, Masaki T. Associations between Zinc Deficiency and Metabolic Abnormalities in Patients with Chronic Liver Disease. Nutrients. 2018;10(1).
Himoto, T., & Masaki, T. (2018). Associations between Zinc Deficiency and Metabolic Abnormalities in Patients with Chronic Liver Disease. Nutrients, 10(1), doi:10.3390/nu10010088.
Himoto T, Masaki T. Associations Between Zinc Deficiency and Metabolic Abnormalities in Patients With Chronic Liver Disease. Nutrients. 2018 Jan 14;10(1) PubMed PMID: 29342898.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Associations between Zinc Deficiency and Metabolic Abnormalities in Patients with Chronic Liver Disease. AU - Himoto,Takashi, AU - Masaki,Tsutomu, Y1 - 2018/01/14/ PY - 2017/12/14/received PY - 2018/01/04/revised PY - 2018/01/05/accepted PY - 2018/1/19/entrez PY - 2018/1/19/pubmed PY - 2018/9/18/medline KW - HCV-related chronic liver disease KW - hepatic encephalopathy KW - hepatic steatosis KW - insulin resistance KW - insulin-like growth factor-1 KW - iron overload KW - lipid peroxidation KW - liver cirrhosis KW - nonalcoholic steatohepatitis KW - zinc deficiency JF - Nutrients JO - Nutrients VL - 10 IS - 1 N2 - Zinc (Zn) is an essential trace element which has favorable antioxidant, anti-inflammatory, and apoptotic effects. The liver mainly plays a crucial role in maintaining systemic Zn homeostasis. Therefore, the occurrence of chronic liver diseases, such as chronic hepatitis, liver cirrhosis, or fatty liver, results in the impairment of Zn metabolism, and subsequently Zn deficiency. Zn deficiency causes plenty of metabolic abnormalities, including insulin resistance, hepatic steatosis and hepatic encephalopathy. Inversely, metabolic abnormalities like hypoalbuminemia in patients with liver cirrhosis often result in Zn deficiency. Recent studies have revealed the putative mechanisms by which Zn deficiency evokes a variety of metabolic abnormalities in chronic liver disease. Zn supplementation has shown beneficial effects on such metabolic abnormalities in experimental models and actual patients with chronic liver disease. This review summarizes the pathogenesis of metabolic abnormalities deriving from Zn deficiency and the favorable effects of Zn administration in patients with chronic liver disease. In addition, we also highlight the interactions between Zn and other trace elements, vitamins, amino acids, or hormones in such patients. SN - 2072-6643 UR - https://www.unboundmedicine.com/medline/citation/29342898/Associations_between_Zinc_Deficiency_and_Metabolic_Abnormalities_in_Patients_with_Chronic_Liver_Disease_ L2 - http://www.mdpi.com/resolver?pii=nu10010088 DB - PRIME DP - Unbound Medicine ER -