TY - JOUR T1 - Correlations among multifocal electroretinography and optical coherence tomography findings in patients with Parkinson's disease. AU - Unlu,Metin, AU - Gulmez Sevim,Duygu, AU - Gultekin,Murat, AU - Karaca,Cagatay, Y1 - 2018/01/18/ PY - 2017/10/24/received PY - 2018/01/02/accepted PY - 2018/1/20/pubmed PY - 2018/8/31/medline PY - 2018/1/20/entrez KW - Multifocal electroretinography KW - Optical coherence tomography KW - Parkinson’s disease KW - Retinal nerve fiber layer KW - Retinal single layers SP - 533 EP - 541 JF - Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology JO - Neurol Sci VL - 39 IS - 3 N2 - To assess the correlation between functional and anatomical evaluations with multifocal electroretinography (mfERG) and spectral-domain optical coherence tomography (SD-OCT) in patients with Parkinson's disease (PD). This cross-sectional study involved 116 eyes of 58 patients with PD and 30 age- and sex-matched control subjects. All study participants underwent a comprehensive neuro-ophthalmic examination, retinal single-layer thicknesses and volumes, and peripapillary retinal nerve fiber layer (pRNFL) measurements with SD-OCT, and the patients' mfERG recordings were evaluated. The macular retinal nerve fiber layer (mRNFL), ganglion cell layer (GCL), inner plexiform layer (IPL), outer nuclear layer (ONL), retinal pigment epithelium (RPE), and photoreceptor layer (PR) thicknesses, and mRNFL, RPE, and PR volumes were found lower in PD compared to those of controls, while outer plexiform layer (OPL) volumes were increased (p < 0.05). We found delayed implicit times and decreased amplitudes in the mfERG of PD patients versus those in control subjects (p < 0.05). We found significant correlations between outer macular volumes, PR thicknesses, and N1 amplitudes of rings 2 and 3and P1 amplitudes of rings 3, 4, and 5. Our study revealed thinning of both inner and outer retinal single layers, increased OPL volume, and delayed implicit times and decreased amplitudes in the mfERG of PD patients versus control subjects and correlation between structural and functional parameters. Our findings point out that SD-OCT and mfERG could both serve as non-invasive tools for evaluating ophthalmic manifestations of Parkinson's disease. SN - 1590-3478 UR - https://www.unboundmedicine.com/medline/citation/29349656/Correlations_among_multifocal_electroretinography_and_optical_coherence_tomography_findings_in_patients_with_Parkinson's_disease_ DB - PRIME DP - Unbound Medicine ER -