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Alginate-based cancer-associated, stimuli-driven and turn-on theranostic prodrug nanogel for cancer detection and treatment.
Carbohydr Polym. 2018 Mar 01; 183:131-139.CP

Abstract

Alginate-based cancer-associated, stimuli-driven and turn-on theranostic prodrug nanogels were designed for the tumor diagnosis and chemotherapy, by crosslinking the folate-terminated poly(ethylene glycol) (FA-PEG-NH2) and rhodamine B (RhB)-terminated poly(ethylene glycol) (RhB-PEG-NH2) modified oxidized alginate (OAL-g-PEG-FA/RhB) with cystamine (Cys), followed covalent conjugation of doxorubicin (DOX) via acid-labile Schiff base bond. Owing to the surface folic acid (FA) groups, disulfide crosslinking structure and Schiff base conjugation for DOX, the folate receptor (FR)-mediated targeting and pH/reduction dual responsive intracellular triggered release of DOX was achieved. The cytotoxicity and cellular uptake results clearly illustrated that most DOX was released and accumulated in the cell nuclei and killed the cancer cells efficaciously, due to the desirable targeting intracellular triggered release. Furthermore, the theranostic nanogels could be used for the real-time and noninvasive location tracking to cancer cells, owing to the pH-modulated fluorescence property of the pendant RhB groups.

Authors+Show Affiliations

State Key Laboratory of Applied Organic Chemistry and Key Laboratory of Nonferrous Metal Chemistry and Resources Utilization of Gansu Province, College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou 730000, China.State Key Laboratory of Applied Organic Chemistry and Key Laboratory of Nonferrous Metal Chemistry and Resources Utilization of Gansu Province, College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou 730000, China.State Key Laboratory of Applied Organic Chemistry and Key Laboratory of Nonferrous Metal Chemistry and Resources Utilization of Gansu Province, College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou 730000, China.State Key Laboratory of Applied Organic Chemistry and Key Laboratory of Nonferrous Metal Chemistry and Resources Utilization of Gansu Province, College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou 730000, China.State Key Laboratory of Applied Organic Chemistry and Key Laboratory of Nonferrous Metal Chemistry and Resources Utilization of Gansu Province, College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou 730000, China. Electronic address: pliu@lzu.edu.cn.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

29352868

Citation

Pei, Mingliang, et al. "Alginate-based Cancer-associated, Stimuli-driven and Turn-on Theranostic Prodrug Nanogel for Cancer Detection and Treatment." Carbohydrate Polymers, vol. 183, 2018, pp. 131-139.
Pei M, Jia X, Zhao X, et al. Alginate-based cancer-associated, stimuli-driven and turn-on theranostic prodrug nanogel for cancer detection and treatment. Carbohydr Polym. 2018;183:131-139.
Pei, M., Jia, X., Zhao, X., Li, J., & Liu, P. (2018). Alginate-based cancer-associated, stimuli-driven and turn-on theranostic prodrug nanogel for cancer detection and treatment. Carbohydrate Polymers, 183, 131-139. https://doi.org/10.1016/j.carbpol.2017.12.013
Pei M, et al. Alginate-based Cancer-associated, Stimuli-driven and Turn-on Theranostic Prodrug Nanogel for Cancer Detection and Treatment. Carbohydr Polym. 2018 Mar 1;183:131-139. PubMed PMID: 29352868.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Alginate-based cancer-associated, stimuli-driven and turn-on theranostic prodrug nanogel for cancer detection and treatment. AU - Pei,Mingliang, AU - Jia,Xu, AU - Zhao,Xubo, AU - Li,Jiagen, AU - Liu,Peng, Y1 - 2017/12/09/ PY - 2017/08/09/received PY - 2017/12/05/revised PY - 2017/12/05/accepted PY - 2018/1/22/entrez PY - 2018/1/22/pubmed PY - 2018/9/6/medline KW - Alginate KW - FR-mediated targeting KW - Fluorescent imaging KW - Intracellular triggered release KW - Theranostic prodrug nanogels SP - 131 EP - 139 JF - Carbohydrate polymers JO - Carbohydr Polym VL - 183 N2 - Alginate-based cancer-associated, stimuli-driven and turn-on theranostic prodrug nanogels were designed for the tumor diagnosis and chemotherapy, by crosslinking the folate-terminated poly(ethylene glycol) (FA-PEG-NH2) and rhodamine B (RhB)-terminated poly(ethylene glycol) (RhB-PEG-NH2) modified oxidized alginate (OAL-g-PEG-FA/RhB) with cystamine (Cys), followed covalent conjugation of doxorubicin (DOX) via acid-labile Schiff base bond. Owing to the surface folic acid (FA) groups, disulfide crosslinking structure and Schiff base conjugation for DOX, the folate receptor (FR)-mediated targeting and pH/reduction dual responsive intracellular triggered release of DOX was achieved. The cytotoxicity and cellular uptake results clearly illustrated that most DOX was released and accumulated in the cell nuclei and killed the cancer cells efficaciously, due to the desirable targeting intracellular triggered release. Furthermore, the theranostic nanogels could be used for the real-time and noninvasive location tracking to cancer cells, owing to the pH-modulated fluorescence property of the pendant RhB groups. SN - 1879-1344 UR - https://www.unboundmedicine.com/medline/citation/29352868/Alginate_based_cancer_associated_stimuli_driven_and_turn_on_theranostic_prodrug_nanogel_for_cancer_detection_and_treatment_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0144-8617(17)31410-8 DB - PRIME DP - Unbound Medicine ER -