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[Acupuncture and Chinese medicine of artificial cycle therapy for insulin resistance of polycystic ovary syndrome with phlegm damp type and its mechanism].
Zhongguo Zhen Jiu. 2017 Nov 12; 37(11):1163-8.ZZ

Abstract

OBJECTIVE

To explore the effect difference between acupuncture combined with Chinese medicine of artificial cycle therapy on the basis of western medication and simple western medication for polycystic ovarian syndrome (PCOS) of phlegm damp type with insulin resistance, and to explore its mechanism.

METHODS

Sixty patients were randomly assigned into an observation group and a control group, 30 cases in each group. Patients of the control group began to take letrozole and metformin orally on the third menstrual day. Patients of the observation group were treated with acupuncture combined with Chinese medicine of artificial cycle therapy on the basis of the treatment of the control group. The main acupoints were Guanyuan (CV 4), Qihai (CV 6) and bilateral Zigong (EX-CA 1), Luanchao (Extra), Fenglong (ST 40), Yinlingquan (SP 9), Zusanli (ST 36), Sanyinjiao (SP 6). Dahe (KI 12) was matched in the follicular phase, and warm acupuncture was applied at Guanyuan (CV 4) and Qihai (CV 6); Zhongji (CV 3) and Xuehai (SP 10) were matched in the ovulatory phase, and electroacupuncture were used at Qihai (CV 6) and Zhongji (CV 3), Xuehai (SP 10) and Yinlingquan (SP 9), 2 Hz and continuous wave; The acupoints in the luteal phase were the above main acupoints, at the same time, moxibustion was used at Guanyuan (CV 4) and Qihai (CV 6), the treatment was given once every other day, 30 min a time. There was no treatment in the menstrual phase. Chinese medicine was applied for tonifying kidney and nourishing blood, strengthening spleen and eliminating phlegm. The patients of the two groups were treated for continuous three menstrual cycles. The indexes before and after treatment were detected, including serum microRNA-29 (miR-29) expression, TCM symptom score, insulin (INS), blood-sugar content and homeostasis model assessment-insulin resistance (HOMA-IR) index, the endocrine hormone values of follicle stimulating hormone (FSH), luteinizing hormone (LH), testosterone (T), LH/FSH ratio, prolactin (PRL). The pregnancy rates of the two groups were compared.

RESULTS

After treatment the expressions of miR-29 and TCM symptom scores of the two groups were lower than those before treatment (P<0.01, P<0.05), with better results in the observation group (P<0.01, P<0.05). The levels of LH LH/FSH and T of the observation group were lower than those before treatment (P<0.01, P<0.05), and the T value in the control group decreased after treatment (P<0.05). The changes of LH and LH/FSH in the observation group were better than those in the control group (both P<0.05). After treatment, The INS, blood-sugar content and HOMA-IR were lower than those before treatment in the two groups (P<0.05, P<0.01), with better results for INS and HOMA-IR improvements in the observation group (both P<0.05). The pregnancy rate in the observation group was 56.7% (17/30), which was significantly higher than 30.0% (9/30) in the control group (P<0.05).

CONCLUSION

Acupuncture combined with Chinese medicine of artificial cycle therapy can improve the endocrine levels and insulin resistance of PCOS with phlegm damp type. At the same time, the pregnancy rate is improved. By the view of molecular biology, there may be a pathway trough changing serum miR-29 expression.

Authors+Show Affiliations

Department of TCM, Fujian Provincial Maternity and Children's Hospital of Fujian Medical University, Fuzhou 350001, China.Department of TCM, Fujian Provincial Maternity and Children's Hospital of Fujian Medical University, Fuzhou 350001, China.Department of TCM, Fujian Provincial Maternity and Children's Hospital of Fujian Medical University, Fuzhou 350001, China.Department of TCM, Fujian Provincial Maternity and Children's Hospital of Fujian Medical University, Fuzhou 350001, China.Department of TCM, Fujian Provincial Maternity and Children's Hospital of Fujian Medical University, Fuzhou 350001, China.Department of TCM, Fujian Provincial Maternity and Children's Hospital of Fujian Medical University, Fuzhou 350001, China.Department of TCM, Fujian Provincial Maternity and Children's Hospital of Fujian Medical University, Fuzhou 350001, China.Department of TCM, Fujian Provincial Maternity and Children's Hospital of Fujian Medical University, Fuzhou 350001, China.Department of TCM, Fujian Provincial Maternity and Children's Hospital of Fujian Medical University, Fuzhou 350001, China.

Pub Type(s)

Journal Article
Randomized Controlled Trial

Language

chi

PubMed ID

29354951

Citation

Yang, Juan, et al. "[Acupuncture and Chinese Medicine of Artificial Cycle Therapy for Insulin Resistance of Polycystic Ovary Syndrome With Phlegm Damp Type and Its Mechanism]." Zhongguo Zhen Jiu = Chinese Acupuncture & Moxibustion, vol. 37, no. 11, 2017, pp. 1163-8.
Yang J, Liu Y, Huang J, et al. [Acupuncture and Chinese medicine of artificial cycle therapy for insulin resistance of polycystic ovary syndrome with phlegm damp type and its mechanism]. Zhongguo Zhen Jiu. 2017;37(11):1163-8.
Yang, J., Liu, Y., Huang, J., Xu, J., You, X., Lin, Q., Zhang, J., Dun, J., & Huang, S. (2017). [Acupuncture and Chinese medicine of artificial cycle therapy for insulin resistance of polycystic ovary syndrome with phlegm damp type and its mechanism]. Zhongguo Zhen Jiu = Chinese Acupuncture & Moxibustion, 37(11), 1163-8. https://doi.org/10.13703/j.0255-2930.2017.11.007
Yang J, et al. [Acupuncture and Chinese Medicine of Artificial Cycle Therapy for Insulin Resistance of Polycystic Ovary Syndrome With Phlegm Damp Type and Its Mechanism]. Zhongguo Zhen Jiu. 2017 Nov 12;37(11):1163-8. PubMed PMID: 29354951.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Acupuncture and Chinese medicine of artificial cycle therapy for insulin resistance of polycystic ovary syndrome with phlegm damp type and its mechanism]. AU - Yang,Juan, AU - Liu,Ying, AU - Huang,Jian, AU - Xu,Jinbang, AU - You,Xiumi, AU - Lin,Qiuping, AU - Zhang,Junxin, AU - Dun,Jingjing, AU - Huang,Shan, PY - 2018/1/23/entrez PY - 2018/1/23/pubmed PY - 2018/7/3/medline KW - Chinese medicine KW - acupuncture KW - insulin resistance KW - polycystic ovary syndrome, phlegm damp type KW - randomized controlled trial (RCT) SP - 1163 EP - 8 JF - Zhongguo zhen jiu = Chinese acupuncture & moxibustion JO - Zhongguo Zhen Jiu VL - 37 IS - 11 N2 - OBJECTIVE: To explore the effect difference between acupuncture combined with Chinese medicine of artificial cycle therapy on the basis of western medication and simple western medication for polycystic ovarian syndrome (PCOS) of phlegm damp type with insulin resistance, and to explore its mechanism. METHODS: Sixty patients were randomly assigned into an observation group and a control group, 30 cases in each group. Patients of the control group began to take letrozole and metformin orally on the third menstrual day. Patients of the observation group were treated with acupuncture combined with Chinese medicine of artificial cycle therapy on the basis of the treatment of the control group. The main acupoints were Guanyuan (CV 4), Qihai (CV 6) and bilateral Zigong (EX-CA 1), Luanchao (Extra), Fenglong (ST 40), Yinlingquan (SP 9), Zusanli (ST 36), Sanyinjiao (SP 6). Dahe (KI 12) was matched in the follicular phase, and warm acupuncture was applied at Guanyuan (CV 4) and Qihai (CV 6); Zhongji (CV 3) and Xuehai (SP 10) were matched in the ovulatory phase, and electroacupuncture were used at Qihai (CV 6) and Zhongji (CV 3), Xuehai (SP 10) and Yinlingquan (SP 9), 2 Hz and continuous wave; The acupoints in the luteal phase were the above main acupoints, at the same time, moxibustion was used at Guanyuan (CV 4) and Qihai (CV 6), the treatment was given once every other day, 30 min a time. There was no treatment in the menstrual phase. Chinese medicine was applied for tonifying kidney and nourishing blood, strengthening spleen and eliminating phlegm. The patients of the two groups were treated for continuous three menstrual cycles. The indexes before and after treatment were detected, including serum microRNA-29 (miR-29) expression, TCM symptom score, insulin (INS), blood-sugar content and homeostasis model assessment-insulin resistance (HOMA-IR) index, the endocrine hormone values of follicle stimulating hormone (FSH), luteinizing hormone (LH), testosterone (T), LH/FSH ratio, prolactin (PRL). The pregnancy rates of the two groups were compared. RESULTS: After treatment the expressions of miR-29 and TCM symptom scores of the two groups were lower than those before treatment (P<0.01, P<0.05), with better results in the observation group (P<0.01, P<0.05). The levels of LH LH/FSH and T of the observation group were lower than those before treatment (P<0.01, P<0.05), and the T value in the control group decreased after treatment (P<0.05). The changes of LH and LH/FSH in the observation group were better than those in the control group (both P<0.05). After treatment, The INS, blood-sugar content and HOMA-IR were lower than those before treatment in the two groups (P<0.05, P<0.01), with better results for INS and HOMA-IR improvements in the observation group (both P<0.05). The pregnancy rate in the observation group was 56.7% (17/30), which was significantly higher than 30.0% (9/30) in the control group (P<0.05). CONCLUSION: Acupuncture combined with Chinese medicine of artificial cycle therapy can improve the endocrine levels and insulin resistance of PCOS with phlegm damp type. At the same time, the pregnancy rate is improved. By the view of molecular biology, there may be a pathway trough changing serum miR-29 expression. SN - 0255-2930 UR - https://www.unboundmedicine.com/medline/citation/29354951/[Acupuncture_and_Chinese_medicine_of_artificial_cycle_therapy_for_insulin_resistance_of_polycystic_ovary_syndrome_with_phlegm_damp_type_and_its_mechanism]_ L2 - https://medlineplus.gov/diabetesmedicines.html DB - PRIME DP - Unbound Medicine ER -