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Inflammatory potential of diet and risk of pancreatic cancer in the Prostate, Lung, Colorectal and Ovarian (PLCO) Cancer Screening Trial.
Int J Cancer 2018; 142(12):2461-2470IJ

Abstract

Inflammation plays a central role in pancreatic cancer etiology and can be modulated by diet. We aimed to examine the association between the inflammatory potential of diet, assessed with the Dietary Inflammatory Index (DII®), and pancreatic cancer risk in the Prostate, Lung, Colorectal and Ovarian Cancer Screening Trial prospective cohort. Our study included 101,449 participants aged 52-78 years at baseline who completed both baseline questionnaire and a diet history questionnaire. Energy-adjusted DII (E-DII) scores were computed based on food and supplement intake. Cox proportional hazards models and time dependent Cox models were used to estimate hazard ratios (HRs) and 95% confidence intervals (CIs) with participants in the lowest E-DII quintile (most anti-inflammatory scores) as referent. After a median 8.5 years of follow-up, 328 pancreatic cancer cases were identified. E-DII scores were not associated with pancreatic cancer risk in the multivariable model (HRQ5vsQ1 = 0.94; 95% CI = 0.66-1.35; p-trend = 0.43). Time significantly modified the association (p-interaction = 0.01). During follow up <4 years, there was suggestive evidence of an inverse association between E-DII and pancreatic cancer (HRQ5vsQ1 = 0.60; 95% CI = 0.35-1.02; p-trend = 0.20) while there was a significant positive trend in the follow up ≥4 years (HRQ5vsQ1 = 1.31; 95% CI = 0.83-2.08; p-trend = 0.03). Similar results were observed for E-DII from food only. Our study does not support an association between inflammatory potential of diet and pancreatic cancer risk; however, heterogeneous results were obtained with different follow-up times. These divergent associations may result from the influences of undetected disease in the short-term.

Authors+Show Affiliations

Department of Epidemiology and Biostatistics, Arnold School of Public Health, University of South Carolina, Columbia, SC. Cancer Prevention and Control Program, University of South Carolina, Columbia, SC. Department of Epidemiology, Division of Cancer Prevention and Population Sciences, The University of Texas MD Anderson Cancer Center, Houston, TX.Department of Epidemiology and Biostatistics, Arnold School of Public Health, University of South Carolina, Columbia, SC.Department of Epidemiology and Biostatistics, Arnold School of Public Health, University of South Carolina, Columbia, SC. Cancer Prevention and Control Program, University of South Carolina, Columbia, SC. Connecting Health Innovations, LLC, Columbia, SC.Department of Epidemiology and Biostatistics, Arnold School of Public Health, University of South Carolina, Columbia, SC.Department of Health Sciences Research, Division of Epidemiology, Mayo Clinic, Jacksonville, FL.Biomedical Informatics Center, Medical University of South Carolina, Charleston, SC.Department of Epidemiology and Biostatistics, Arnold School of Public Health, University of South Carolina, Columbia, SC. Cancer Prevention and Control Program, University of South Carolina, Columbia, SC. Connecting Health Innovations, LLC, Columbia, SC.Division of Cancer Epidemiology and Genetics, Metabolic Epidemiology Branch, National Cancer Institute (NCI/DCEG), Rockville, MD.Department of Epidemiology and Biostatistics, Arnold School of Public Health, University of South Carolina, Columbia, SC. Cancer Prevention and Control Program, University of South Carolina, Columbia, SC. Connecting Health Innovations, LLC, Columbia, SC.Department of Epidemiology and Biostatistics, Arnold School of Public Health, University of South Carolina, Columbia, SC. Cancer Prevention and Control Program, University of South Carolina, Columbia, SC.

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

29355939

Citation

Zheng, Jiali, et al. "Inflammatory Potential of Diet and Risk of Pancreatic Cancer in the Prostate, Lung, Colorectal and Ovarian (PLCO) Cancer Screening Trial." International Journal of Cancer, vol. 142, no. 12, 2018, pp. 2461-2470.
Zheng J, Merchant AT, Wirth MD, et al. Inflammatory potential of diet and risk of pancreatic cancer in the Prostate, Lung, Colorectal and Ovarian (PLCO) Cancer Screening Trial. Int J Cancer. 2018;142(12):2461-2470.
Zheng, J., Merchant, A. T., Wirth, M. D., Zhang, J., Antwi, S. O., Shoaibi, A., ... Steck, S. E. (2018). Inflammatory potential of diet and risk of pancreatic cancer in the Prostate, Lung, Colorectal and Ovarian (PLCO) Cancer Screening Trial. International Journal of Cancer, 142(12), pp. 2461-2470. doi:10.1002/ijc.31271.
Zheng J, et al. Inflammatory Potential of Diet and Risk of Pancreatic Cancer in the Prostate, Lung, Colorectal and Ovarian (PLCO) Cancer Screening Trial. Int J Cancer. 2018 06 15;142(12):2461-2470. PubMed PMID: 29355939.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Inflammatory potential of diet and risk of pancreatic cancer in the Prostate, Lung, Colorectal and Ovarian (PLCO) Cancer Screening Trial. AU - Zheng,Jiali, AU - Merchant,Anwar T, AU - Wirth,Michael D, AU - Zhang,Jiajia, AU - Antwi,Samuel O, AU - Shoaibi,Azza, AU - Shivappa,Nitin, AU - Stolzenberg-Solomon,Rachael Z, AU - Hebert,James R, AU - Steck,Susan E, Y1 - 2018/02/02/ PY - 2017/08/21/received PY - 2017/12/30/revised PY - 2018/01/09/accepted PY - 2018/1/23/pubmed PY - 2018/12/12/medline PY - 2018/1/23/entrez KW - cohort study KW - dietary inflammatory index KW - dietary patterns KW - incidence KW - pancreatic cancer SP - 2461 EP - 2470 JF - International journal of cancer JO - Int. J. Cancer VL - 142 IS - 12 N2 - Inflammation plays a central role in pancreatic cancer etiology and can be modulated by diet. We aimed to examine the association between the inflammatory potential of diet, assessed with the Dietary Inflammatory Index (DII®), and pancreatic cancer risk in the Prostate, Lung, Colorectal and Ovarian Cancer Screening Trial prospective cohort. Our study included 101,449 participants aged 52-78 years at baseline who completed both baseline questionnaire and a diet history questionnaire. Energy-adjusted DII (E-DII) scores were computed based on food and supplement intake. Cox proportional hazards models and time dependent Cox models were used to estimate hazard ratios (HRs) and 95% confidence intervals (CIs) with participants in the lowest E-DII quintile (most anti-inflammatory scores) as referent. After a median 8.5 years of follow-up, 328 pancreatic cancer cases were identified. E-DII scores were not associated with pancreatic cancer risk in the multivariable model (HRQ5vsQ1 = 0.94; 95% CI = 0.66-1.35; p-trend = 0.43). Time significantly modified the association (p-interaction = 0.01). During follow up <4 years, there was suggestive evidence of an inverse association between E-DII and pancreatic cancer (HRQ5vsQ1 = 0.60; 95% CI = 0.35-1.02; p-trend = 0.20) while there was a significant positive trend in the follow up ≥4 years (HRQ5vsQ1 = 1.31; 95% CI = 0.83-2.08; p-trend = 0.03). Similar results were observed for E-DII from food only. Our study does not support an association between inflammatory potential of diet and pancreatic cancer risk; however, heterogeneous results were obtained with different follow-up times. These divergent associations may result from the influences of undetected disease in the short-term. SN - 1097-0215 UR - https://www.unboundmedicine.com/medline/citation/29355939/Inflammatory_potential_of_diet_and_risk_of_pancreatic_cancer_in_the_Prostate_Lung_Colorectal_and_Ovarian__PLCO__Cancer_Screening_Trial_ L2 - https://doi.org/10.1002/ijc.31271 DB - PRIME DP - Unbound Medicine ER -