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Third molar agenesis as a potential marker for craniofacial deformities.
Arch Oral Biol. 2018 Apr; 88:19-23.AO

Abstract

The identification of clinical patterns of tooth agenesis in individuals born with craniofacial deformities may be a useful tool for risk determination of these defects. We hypothesize that specific craniofacial deformities are associated with third molar agenesis.

OBJECTIVE

The aim of this study was to identify if third molar agenesis could have a relation with other craniofacial structure alterations, such as cleft lip and palate, skeletal malocclusion, or specific growth patterns in humans.

DESIGN

Data were obtained from 550 individuals ascertained as part of studies aiming to identify genetic contributions to oral clefts. 831 dental records of patients aged over eight years seeking orthodontic treatment were also included. SN-GoGn angle were used to classify the growth pattern (hypo-divergent, normal and hyper-divergent), and the ANB angle was used to verify the skeletal malocclusion pattern (Class I, II and III). Panoramic radiographs were used to determine third molar agenesis.

RESULTS

A high frequency of third molar agenesis among individuals born with cleft lip with or without cleft palate (55%), as well as among their relatives (93.5%) was found. Third molar agenesis was not associated to skeletal malocclusion or growth pattern.

CONCLUSION

It appears that third molar agenesis is associated with the disturbances that lead to cleft lip and palate.

Authors+Show Affiliations

Department of Pediatric Dentistry and Orthodontics, School of Dentistry, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil.Department of Pediatric Dentistry and Orthodontics, School of Dentistry, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil.Institute for Studies in Public Health, IESC, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil.Department of Oral Biology and Center of Craniofacial and Dental Genetics, University of Pittsburgh School of Dental Medicine.ECLAMC at CEMIC, Buenos Aires, Argentina.ECLAMC at CEMIC, Buenos Aires, Argentina.ECLAMC at LEMC (Laboratory of Congenital Malformations Epidemiology), Oswaldo Cruz Institute, FIOCRUZ, Rio de Janeiro, Brazil.ECLAMC at CEMIC, Buenos Aires, Argentina.ECLAMC at CEMIC, Buenos Aires, Argentina.ECLAMC at CEMIC, Buenos Aires, Argentina.ECLAMC at Department of Genetics, Institute of Biology, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil.Department of Pediatric Dentistry and Orthodontics, School of Dentistry, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil.Department of Oral Biology and Center of Craniofacial and Dental Genetics, University of Pittsburgh School of Dental Medicine. Electronic address: alexandre_vieira@pitt.edu.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

29358133

Citation

Fernandez, Clarissa Christina Avelar, et al. "Third Molar Agenesis as a Potential Marker for Craniofacial Deformities." Archives of Oral Biology, vol. 88, 2018, pp. 19-23.
Fernandez CCA, Pereira CVCA, Luiz RR, et al. Third molar agenesis as a potential marker for craniofacial deformities. Arch Oral Biol. 2018;88:19-23.
Fernandez, C. C. A., Pereira, C. V. C. A., Luiz, R. R., Faraco, I. M., Marazita, M. L., Arnaudo, M., de Carvalho, F. M., Poletta, F. E., Mereb, J. C., Castilla, E. E., Orioli, I. M., de Castro Costa, M., & Vieira, A. R. (2018). Third molar agenesis as a potential marker for craniofacial deformities. Archives of Oral Biology, 88, 19-23. https://doi.org/10.1016/j.archoralbio.2018.01.010
Fernandez CCA, et al. Third Molar Agenesis as a Potential Marker for Craniofacial Deformities. Arch Oral Biol. 2018;88:19-23. PubMed PMID: 29358133.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Third molar agenesis as a potential marker for craniofacial deformities. AU - Fernandez,Clarissa Christina Avelar, AU - Pereira,Christiane Vasconcellos Cruz Alves, AU - Luiz,Ronir Raggio, AU - Faraco,Italo M,Jr AU - Marazita,Mary L, AU - Arnaudo,Maria, AU - de Carvalho,Flavia M, AU - Poletta,Fernando E, AU - Mereb,Juan C, AU - Castilla,Eduardo E, AU - Orioli,Iêda M, AU - de Castro Costa,Marcelo, AU - Vieira,Alexandre Rezende, Y1 - 2018/01/19/ PY - 2017/09/19/received PY - 2018/01/05/revised PY - 2018/01/16/accepted PY - 2018/1/24/pubmed PY - 2018/10/6/medline PY - 2018/1/24/entrez KW - Cleft lip and palate KW - Craniofacial deformities KW - Tooth agenesis SP - 19 EP - 23 JF - Archives of oral biology JO - Arch. Oral Biol. VL - 88 N2 - : The identification of clinical patterns of tooth agenesis in individuals born with craniofacial deformities may be a useful tool for risk determination of these defects. We hypothesize that specific craniofacial deformities are associated with third molar agenesis. OBJECTIVE: The aim of this study was to identify if third molar agenesis could have a relation with other craniofacial structure alterations, such as cleft lip and palate, skeletal malocclusion, or specific growth patterns in humans. DESIGN: Data were obtained from 550 individuals ascertained as part of studies aiming to identify genetic contributions to oral clefts. 831 dental records of patients aged over eight years seeking orthodontic treatment were also included. SN-GoGn angle were used to classify the growth pattern (hypo-divergent, normal and hyper-divergent), and the ANB angle was used to verify the skeletal malocclusion pattern (Class I, II and III). Panoramic radiographs were used to determine third molar agenesis. RESULTS: A high frequency of third molar agenesis among individuals born with cleft lip with or without cleft palate (55%), as well as among their relatives (93.5%) was found. Third molar agenesis was not associated to skeletal malocclusion or growth pattern. CONCLUSION: It appears that third molar agenesis is associated with the disturbances that lead to cleft lip and palate. SN - 1879-1506 UR - https://www.unboundmedicine.com/medline/citation/29358133/Third_molar_agenesis_as_a_potential_marker_for_craniofacial_deformities_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0003-9969(18)30010-4 DB - PRIME DP - Unbound Medicine ER -