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Does spotty calcification attenuate the response of nonculprit plaque to statin therapy?: A serial optical coherence tomography study.
Catheter Cardiovasc Interv. 2018 02 15; 91(S1):582-590.CC

Abstract

OBJECTIVES

The aim of this study was to determine if spotty calcification decreases the response of plaque progression to statin therapy.

BACKGROUND

Previous studies showed that the presence of spotty calcification is a marker of vulnerable plaque. However, the relationship between spotty calcification and plaque progression is not clear.

METHODS

Ninety-six nonculprit lipid-rich plaques in 69 patients who received serial optical coherence tomography (OCT) imaging were included. Plaques were divided into three groups: spotty calcification (n = 38), calcified (n = 12) and noncalcified (n = 46) plaques. Spotty calcification was identified by the presence of a lesion <4 mm in length with an arc of calcification <90°. Changes in plaque characteristics and fibrous cap thickness (FCT) at 6 and 12 months under statin therapy were analyzed by OCT.

RESULTS

The increase of FCT was sustained from baseline to 6 and 12 months in three groups: spotty calcification (62.8 ± 20.9, 126.4 ± 84.9, and 169.2 ± 81.6 μm, respectively; P < .001), calcified (59.8 ± 17.0, 93.4 ± 51.4, and 155.2 ± 61.7 μm, respectively; P < .001) and noncalcified (60.0 ± 17.2, 125.5 ± 62.1, and 161.0 ± 80.5 μm, respectively; P < .001). Intensive statin induced a greater change in FCT at 12 months than moderate statin in the spotty calcification group (P = 0.034). The mean lipid arc decreased significantly at 12 months from baseline in the three groups (P = 0.004, P = 0.023, and P < .001, respectively).

CONCLUSIONS

Statin therapy was effective for plaque stabilization in plaques with and without spotty calcification. Patients with spotty calcification benefitted more from intensive statin than from moderate statin therapy.

Authors+Show Affiliations

Department of Cardiology, The 2nd Affiliated Hospital of Harbin Medical University, The Key Laboratory of Myocardial Ischemia, Chinese Ministry of Education, Harbin, China.Department of Cardiology, The 2nd Affiliated Hospital of Harbin Medical University, The Key Laboratory of Myocardial Ischemia, Chinese Ministry of Education, Harbin, China. Bashkir State Medical University, Ufa, Republic Bashkortostan, Russian Federation.Department of Cardiology, The 2nd Affiliated Hospital of Harbin Medical University, The Key Laboratory of Myocardial Ischemia, Chinese Ministry of Education, Harbin, China.Department of Cardiology, The 2nd Affiliated Hospital of Harbin Medical University, The Key Laboratory of Myocardial Ischemia, Chinese Ministry of Education, Harbin, China.Department of Cardiology, The 2nd Affiliated Hospital of Harbin Medical University, The Key Laboratory of Myocardial Ischemia, Chinese Ministry of Education, Harbin, China.Department of Cardiology, The 2nd Affiliated Hospital of Harbin Medical University, The Key Laboratory of Myocardial Ischemia, Chinese Ministry of Education, Harbin, China.Harbin Medical University, Harbin, China.Department of Cardiology, The 2nd Affiliated Hospital of Harbin Medical University, The Key Laboratory of Myocardial Ischemia, Chinese Ministry of Education, Harbin, China.Interventional Cardiology Unit, Azienda Ospedaliera Papa Giovanni XXIII, Bergamo, Italy.Department of Cardiology, The 2nd Affiliated Hospital of Harbin Medical University, The Key Laboratory of Myocardial Ischemia, Chinese Ministry of Education, Harbin, China.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

29359491

Citation

Afolabi, Abigail, et al. "Does Spotty Calcification Attenuate the Response of Nonculprit Plaque to Statin Therapy?: a Serial Optical Coherence Tomography Study." Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions, vol. 91, no. S1, 2018, pp. 582-590.
Afolabi A, Mustafina I, Zhao L, et al. Does spotty calcification attenuate the response of nonculprit plaque to statin therapy?: A serial optical coherence tomography study. Catheter Cardiovasc Interv. 2018;91(S1):582-590.
Afolabi, A., Mustafina, I., Zhao, L., Li, L., Sun, R., Hu, S., Zhang, S., Jia, H., Guilio, G., & Yu, B. (2018). Does spotty calcification attenuate the response of nonculprit plaque to statin therapy?: A serial optical coherence tomography study. Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions, 91(S1), 582-590. https://doi.org/10.1002/ccd.27496
Afolabi A, et al. Does Spotty Calcification Attenuate the Response of Nonculprit Plaque to Statin Therapy?: a Serial Optical Coherence Tomography Study. Catheter Cardiovasc Interv. 2018 02 15;91(S1):582-590. PubMed PMID: 29359491.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Does spotty calcification attenuate the response of nonculprit plaque to statin therapy?: A serial optical coherence tomography study. AU - Afolabi,Abigail, AU - Mustafina,Irina, AU - Zhao,Linlin, AU - Li,Lulu, AU - Sun,Rong, AU - Hu,Sining, AU - Zhang,Shaosong, AU - Jia,Haibo, AU - Guilio,Guagliumi, AU - Yu,Bo, Y1 - 2018/01/23/ PY - 2017/12/10/received PY - 2017/12/27/accepted PY - 2018/1/24/pubmed PY - 2019/3/15/medline PY - 2018/1/24/entrez KW - lipid-rich plaque KW - optical coherence tomography KW - spotty calcification KW - statin therapy SP - 582 EP - 590 JF - Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions JO - Catheter Cardiovasc Interv VL - 91 IS - S1 N2 - OBJECTIVES: The aim of this study was to determine if spotty calcification decreases the response of plaque progression to statin therapy. BACKGROUND: Previous studies showed that the presence of spotty calcification is a marker of vulnerable plaque. However, the relationship between spotty calcification and plaque progression is not clear. METHODS: Ninety-six nonculprit lipid-rich plaques in 69 patients who received serial optical coherence tomography (OCT) imaging were included. Plaques were divided into three groups: spotty calcification (n = 38), calcified (n = 12) and noncalcified (n = 46) plaques. Spotty calcification was identified by the presence of a lesion <4 mm in length with an arc of calcification <90°. Changes in plaque characteristics and fibrous cap thickness (FCT) at 6 and 12 months under statin therapy were analyzed by OCT. RESULTS: The increase of FCT was sustained from baseline to 6 and 12 months in three groups: spotty calcification (62.8 ± 20.9, 126.4 ± 84.9, and 169.2 ± 81.6 μm, respectively; P < .001), calcified (59.8 ± 17.0, 93.4 ± 51.4, and 155.2 ± 61.7 μm, respectively; P < .001) and noncalcified (60.0 ± 17.2, 125.5 ± 62.1, and 161.0 ± 80.5 μm, respectively; P < .001). Intensive statin induced a greater change in FCT at 12 months than moderate statin in the spotty calcification group (P = 0.034). The mean lipid arc decreased significantly at 12 months from baseline in the three groups (P = 0.004, P = 0.023, and P < .001, respectively). CONCLUSIONS: Statin therapy was effective for plaque stabilization in plaques with and without spotty calcification. Patients with spotty calcification benefitted more from intensive statin than from moderate statin therapy. SN - 1522-726X UR - https://www.unboundmedicine.com/medline/citation/29359491/Does_spotty_calcification_attenuate_the_response_of_nonculprit_plaque_to_statin_therapy:_A_serial_optical_coherence_tomography_study_ DB - PRIME DP - Unbound Medicine ER -