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Effect of resveratrol on blood pressure: A systematic review and meta-analysis of randomized, controlled, clinical trials.
Crit Rev Food Sci Nutr. 2019; 59(10):1605-1618.CR

Abstract

Introduction: Results of previous clinical trials evaluating the effect of resveratrol supplementation on blood pressure (BP) are controversial.

Purpose:

We aimed to assess the impact of resveratrol on BP through systematic review of literature and meta-analysis of available randomized, controlled clinical trials (RCTs).

Methods:

Literature search included SCOPUS, PubMed-Medline, ISI Web of Science and Google Scholar databases up to 17th October 2017 to identify RCTs investigating the impact of resveratrol on BP. Two review authors independently extracted data on study characteristics, methods and outcomes. Overall, the impact of resveratrol on BP was reported in 17 trials.

Results:

Administration of resveratrol did not significantly affect neither systolic BP [weighted mean difference (WMD): -2.5 95% CI:(-5.5, 0.6) mmHg; p=0.116; I2=62.1%], nor diastolic BP [WMD: -0.5 95% CI:(-2.2, 1.3) mmHg; p=0.613; I2=50.8], nor mean BP [MAP; WMD: -1.3 95% CI:(-2.8, 0.1) mmHg; p=0.070; I2=39.5%] nor pulse pressure [PP; WMD: -0.9 95% CI:(-3.1, 1.4) mmHg; p=0.449; I2=19.2%]. However, significant WMDs were detected in subsets of studies categorized according to high resveratrol daily dosage (≥300 mg/day) and presence of diabetes. Meta-regression analysis revealed a positive association between systolic BP-lowering resveratrol activity (slope: 1.99; 95% CI: 0.05, 3.93; two-tailed p= 0.04) and Body Mass Index (BMI) at baseline, while no association was detected neither between baseline BMI and MAP-lowering resveratrol activity (slope: 1.35; 95% CI: -0.22, 2.91; two-tailed p= 0.09) nor between baseline BMI and PP-lowering resveratrol activity (slope: 1.03; 95% CI: -1.33, 3.39; two-tailed p= 0.39). Resveratrol was fairly well-tolerated and no serious adverse events occurred among most of the eligible trials.

Conclusion:

The favourable effect of resveratrol emerging from the current meta-analysis suggests the possible use of this nutraceutical as active compound in order to promote cardiovascular health, mostly when used in high daily dose (≥300 mg/day) and in diabetic patients.

Authors+Show Affiliations

a Medical and Surgical Sciences Dept. , University of Bologna , Italy.b Division of Cardiology, Department of Clinical and Molecular Medicine , Faculty of Medicine and Psychology, University of Rome Sapienza, Sant'Andrea Hospital, Rome, and IRCCS Neuromed , Pozzilli (IS), Italy.b Division of Cardiology, Department of Clinical and Molecular Medicine , Faculty of Medicine and Psychology, University of Rome Sapienza, Sant'Andrea Hospital, Rome, and IRCCS Neuromed , Pozzilli (IS), Italy.c Labomar R&D , Istrana , Italy.a Medical and Surgical Sciences Dept. , University of Bologna , Italy.a Medical and Surgical Sciences Dept. , University of Bologna , Italy.

Pub Type(s)

Journal Article
Meta-Analysis
Systematic Review

Language

eng

PubMed ID

29359958

Citation

Fogacci, Federica, et al. "Effect of Resveratrol On Blood Pressure: a Systematic Review and Meta-analysis of Randomized, Controlled, Clinical Trials." Critical Reviews in Food Science and Nutrition, vol. 59, no. 10, 2019, pp. 1605-1618.
Fogacci F, Tocci G, Presta V, et al. Effect of resveratrol on blood pressure: A systematic review and meta-analysis of randomized, controlled, clinical trials. Crit Rev Food Sci Nutr. 2019;59(10):1605-1618.
Fogacci, F., Tocci, G., Presta, V., Fratter, A., Borghi, C., & Cicero, A. F. G. (2019). Effect of resveratrol on blood pressure: A systematic review and meta-analysis of randomized, controlled, clinical trials. Critical Reviews in Food Science and Nutrition, 59(10), 1605-1618. https://doi.org/10.1080/10408398.2017.1422480
Fogacci F, et al. Effect of Resveratrol On Blood Pressure: a Systematic Review and Meta-analysis of Randomized, Controlled, Clinical Trials. Crit Rev Food Sci Nutr. 2019;59(10):1605-1618. PubMed PMID: 29359958.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of resveratrol on blood pressure: A systematic review and meta-analysis of randomized, controlled, clinical trials. AU - Fogacci,Federica, AU - Tocci,Giuliano, AU - Presta,Vivianne, AU - Fratter,Andrea, AU - Borghi,Claudio, AU - Cicero,Arrigo F G, Y1 - 2018/01/23/ PY - 2018/1/24/pubmed PY - 2018/1/24/medline PY - 2018/1/24/entrez KW - Resveratrol KW - blood pressure KW - meta-analysis KW - metaregression KW - type 2 diabetes SP - 1605 EP - 1618 JF - Critical reviews in food science and nutrition JO - Crit Rev Food Sci Nutr VL - 59 IS - 10 N2 - Introduction: Results of previous clinical trials evaluating the effect of resveratrol supplementation on blood pressure (BP) are controversial. Purpose: We aimed to assess the impact of resveratrol on BP through systematic review of literature and meta-analysis of available randomized, controlled clinical trials (RCTs). Methods: Literature search included SCOPUS, PubMed-Medline, ISI Web of Science and Google Scholar databases up to 17th October 2017 to identify RCTs investigating the impact of resveratrol on BP. Two review authors independently extracted data on study characteristics, methods and outcomes. Overall, the impact of resveratrol on BP was reported in 17 trials. Results: Administration of resveratrol did not significantly affect neither systolic BP [weighted mean difference (WMD): -2.5 95% CI:(-5.5, 0.6) mmHg; p=0.116; I2=62.1%], nor diastolic BP [WMD: -0.5 95% CI:(-2.2, 1.3) mmHg; p=0.613; I2=50.8], nor mean BP [MAP; WMD: -1.3 95% CI:(-2.8, 0.1) mmHg; p=0.070; I2=39.5%] nor pulse pressure [PP; WMD: -0.9 95% CI:(-3.1, 1.4) mmHg; p=0.449; I2=19.2%]. However, significant WMDs were detected in subsets of studies categorized according to high resveratrol daily dosage (≥300 mg/day) and presence of diabetes. Meta-regression analysis revealed a positive association between systolic BP-lowering resveratrol activity (slope: 1.99; 95% CI: 0.05, 3.93; two-tailed p= 0.04) and Body Mass Index (BMI) at baseline, while no association was detected neither between baseline BMI and MAP-lowering resveratrol activity (slope: 1.35; 95% CI: -0.22, 2.91; two-tailed p= 0.09) nor between baseline BMI and PP-lowering resveratrol activity (slope: 1.03; 95% CI: -1.33, 3.39; two-tailed p= 0.39). Resveratrol was fairly well-tolerated and no serious adverse events occurred among most of the eligible trials. Conclusion: The favourable effect of resveratrol emerging from the current meta-analysis suggests the possible use of this nutraceutical as active compound in order to promote cardiovascular health, mostly when used in high daily dose (≥300 mg/day) and in diabetic patients. SN - 1549-7852 UR - https://www.unboundmedicine.com/medline/citation/29359958/Effect_of_resveratrol_on_blood_pressure:_A_systematic_review_and_meta_analysis_of_randomized_controlled_clinical_trials_ L2 - http://www.tandfonline.com/doi/full/10.1080/10408398.2017.1422480 DB - PRIME DP - Unbound Medicine ER -