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Pseudoexfoliation syndrome without glaucoma: White matter abnormalities detected by conventional MRI and diffusion tensor imaging.
Eur J Radiol. 2018 Feb; 99:82-87.EJ

Abstract

PURPOSE

To assess macro- and microstructural brain changes in patients with pseudoexfoliation syndrome (PXS).

MATERIALS AND METHODS

Comprehensive ophthalmic examination and brain MRI were conducted on 20 patients with PXS without glaucoma (aged 62.75 ± 0.4 years) and 20 controls (aged 62 ± 0.6 years). White matter (WM) integrity was evaluated on FLAIR and single-shot multisection SE-EPI diffusion tensor imaging (DTI) sequences. The presence and the number of white matter hyperintensities (WMHIs) on FLAIR images was compared between all patients and control subjects. Microstructural WM changes on DTI was evaluated using Tract-based spatial statistics (TBSS). DTI metrics of the optic tracts were assessed by the region-of-interest (ROI) method.

RESULTS

A significantly higher number of WMHIs was found in the patients with PXS than in the control subjects (P ≤ 0.002). On DTI the patients showed bilateral increase in the mean diffusivity (MD), axial diffusivity (AD) and radial diffusivity (RD) values in the anterior thalamic radiation, the inferior fronto-occipital fasciculus, the superior longitudinal fasciculus, the inferior longitudinal fasciculus and the forceps minor. TBSS revealed no significant difference in fractional anisotropy (FA) values, but ROIs analysis of the optic tracts revealed decreased FA values in the patients.

CONCLUSION

MRI in patients with PXS detects abnormalities in the brain and the optic tracts at a subclinical stage. Early detection of microstructural changes could be useful to guide appropriate treatment to impede the disease process.

Authors+Show Affiliations

Department of Radiology, Medical School, University of Ioannina, Greece.Department of Ophthalmology, Medical School, University of Ioannina, Greece.Department of Medical Physics, Medical School, University of Ioannina, Greece.Department of Radiology, Medical School, University of Ioannina, Greece.Department of Ophthalmology, Medical School, University of Ioannina, Greece.Department of Ophthalmology, Medical School, University of Ioannina, Greece.Department of Radiology, Medical School, University of Ioannina, Greece. Electronic address: margyrop@cc.uoi.gr.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

29362155

Citation

Zikou, Anastasia K., et al. "Pseudoexfoliation Syndrome Without Glaucoma: White Matter Abnormalities Detected By Conventional MRI and Diffusion Tensor Imaging." European Journal of Radiology, vol. 99, 2018, pp. 82-87.
Zikou AK, Kitsos G, Astrakas LG, et al. Pseudoexfoliation syndrome without glaucoma: White matter abnormalities detected by conventional MRI and diffusion tensor imaging. Eur J Radiol. 2018;99:82-87.
Zikou, A. K., Kitsos, G., Astrakas, L. G., Xydis, V. G., Spiliopoulos, K., Bagli, E., & Argyropoulou, M. I. (2018). Pseudoexfoliation syndrome without glaucoma: White matter abnormalities detected by conventional MRI and diffusion tensor imaging. European Journal of Radiology, 99, 82-87. https://doi.org/10.1016/j.ejrad.2017.12.019
Zikou AK, et al. Pseudoexfoliation Syndrome Without Glaucoma: White Matter Abnormalities Detected By Conventional MRI and Diffusion Tensor Imaging. Eur J Radiol. 2018;99:82-87. PubMed PMID: 29362155.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Pseudoexfoliation syndrome without glaucoma: White matter abnormalities detected by conventional MRI and diffusion tensor imaging. AU - Zikou,Anastasia K, AU - Kitsos,George, AU - Astrakas,Loukas G, AU - Xydis,Vasileios G, AU - Spiliopoulos,Konstantinos, AU - Bagli,Eleni, AU - Argyropoulou,Maria I, Y1 - 2017/12/26/ PY - 2017/06/19/received PY - 2017/12/22/revised PY - 2017/12/24/accepted PY - 2018/1/25/entrez PY - 2018/1/25/pubmed PY - 2018/7/10/medline KW - Diffusion tensor imaging KW - Magnetic resonance imaging KW - Pseudoexfoliation syndrome KW - Tract-based spatial statistics KW - White matter hyperintensities SP - 82 EP - 87 JF - European journal of radiology JO - Eur J Radiol VL - 99 N2 - PURPOSE: To assess macro- and microstructural brain changes in patients with pseudoexfoliation syndrome (PXS). MATERIALS AND METHODS: Comprehensive ophthalmic examination and brain MRI were conducted on 20 patients with PXS without glaucoma (aged 62.75 ± 0.4 years) and 20 controls (aged 62 ± 0.6 years). White matter (WM) integrity was evaluated on FLAIR and single-shot multisection SE-EPI diffusion tensor imaging (DTI) sequences. The presence and the number of white matter hyperintensities (WMHIs) on FLAIR images was compared between all patients and control subjects. Microstructural WM changes on DTI was evaluated using Tract-based spatial statistics (TBSS). DTI metrics of the optic tracts were assessed by the region-of-interest (ROI) method. RESULTS: A significantly higher number of WMHIs was found in the patients with PXS than in the control subjects (P ≤ 0.002). On DTI the patients showed bilateral increase in the mean diffusivity (MD), axial diffusivity (AD) and radial diffusivity (RD) values in the anterior thalamic radiation, the inferior fronto-occipital fasciculus, the superior longitudinal fasciculus, the inferior longitudinal fasciculus and the forceps minor. TBSS revealed no significant difference in fractional anisotropy (FA) values, but ROIs analysis of the optic tracts revealed decreased FA values in the patients. CONCLUSION: MRI in patients with PXS detects abnormalities in the brain and the optic tracts at a subclinical stage. Early detection of microstructural changes could be useful to guide appropriate treatment to impede the disease process. SN - 1872-7727 UR - https://www.unboundmedicine.com/medline/citation/29362155/Pseudoexfoliation_syndrome_without_glaucoma:_White_matter_abnormalities_detected_by_conventional_MRI_and_diffusion_tensor_imaging_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0720-048X(17)30541-7 DB - PRIME DP - Unbound Medicine ER -