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Detection of Zika Virus Infection in Myanmar.
Am J Trop Med Hyg. 2018 03; 98(3):868-871.AJ

Abstract

Zika virus (ZIKV), an emerging mosquito-borne flavivirus, causes a dengue-like infection that has recently caught global attention. The infection, which also includes some birth defects, has been documented in the Americas, Pacific Islands, and some parts of Africa and Asia. There are no published reports on local ZIKV transmission in Myanmar. In this study, a total of 462 serum samples from patients and asymptomatic persons were collected in Myanmar from 2004 to 2017. They were analyzed for ZIKV infection by immunoglobulin M capture enzyme-linked immunosorbent assay (ELISA), immunoglobulin G indirect ELISA, neutralization test, real-time polymerase chain reaction (PCR), and conventional PCR. Our study confirmed ZIKV infection in 4.9% of patients with clinical dengue symptoms and in 8.6% of persons who were asymptomatic. This is the first report on ZIKV infection in Myanmar and it suggests the occurrence of ZIKV infection in two geographically distinct sites in this country since at least 2006.

Authors+Show Affiliations

Department of Virology, Institute of Tropical Medicine, Nagasaki University, Nagasaki, Japan.Virology Research Division, Department of Medical Research, Pyin Oo Lwin, Myanmar. Department of Virology, Institute of Tropical Medicine, Nagasaki University, Nagasaki, Japan.Department of Pathology, University of Medicine-1, Yangon, Myanmar.Department of Virology, Institute of Tropical Medicine, Nagasaki University, Nagasaki, Japan.Research and Biotechnology Division, St. Luke's Medical Center, Quezon City, Philippines. Department of Virology, Institute of Tropical Medicine, Nagasaki University, Nagasaki, Japan.Virology Research Division, Department of Medical Research, Pyin Oo Lwin, Myanmar. Department of Virology, Institute of Tropical Medicine, Nagasaki University, Nagasaki, Japan.Department of Virology, Institute of Tropical Medicine, Nagasaki University, Nagasaki, Japan.Department of Virology, Institute of Tropical Medicine, Nagasaki University, Nagasaki, Japan.Virology Research Division, Department of Medical Research, Pyin Oo Lwin, Myanmar.Department of Virology, Institute of Tropical Medicine, Nagasaki University, Nagasaki, Japan.Virology Research Division, Department of Medical Research, Pyin Oo Lwin, Myanmar.Department of Virology, Institute of Tropical Medicine, Nagasaki University, Nagasaki, Japan.

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

29363460

Citation

Ngwe Tun, Mya Myat, et al. "Detection of Zika Virus Infection in Myanmar." The American Journal of Tropical Medicine and Hygiene, vol. 98, no. 3, 2018, pp. 868-871.
Ngwe Tun MM, Kyaw AK, Hmone SW, et al. Detection of Zika Virus Infection in Myanmar. Am J Trop Med Hyg. 2018;98(3):868-871.
Ngwe Tun, M. M., Kyaw, A. K., Hmone, S. W., Inoue, S., Buerano, C. C., Soe, A. M., Moi, M. L., Hayasaka, D., Thu, H. M., Hasebe, F., Thant, K. Z., & Morita, K. (2018). Detection of Zika Virus Infection in Myanmar. The American Journal of Tropical Medicine and Hygiene, 98(3), 868-871. https://doi.org/10.4269/ajtmh.17-0708
Ngwe Tun MM, et al. Detection of Zika Virus Infection in Myanmar. Am J Trop Med Hyg. 2018;98(3):868-871. PubMed PMID: 29363460.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Detection of Zika Virus Infection in Myanmar. AU - Ngwe Tun,Mya Myat, AU - Kyaw,Aung Kyaw, AU - Hmone,Saw Wut, AU - Inoue,Shingo, AU - Buerano,Corazon C, AU - Soe,Aung Min, AU - Moi,Meng Ling, AU - Hayasaka,Daisuke, AU - Thu,Hlaing Myat, AU - Hasebe,Futoshi, AU - Thant,Kyaw Zin, AU - Morita,Kouichi, Y1 - 2018/01/18/ PY - 2018/1/25/pubmed PY - 2018/12/12/medline PY - 2018/1/25/entrez SP - 868 EP - 871 JF - The American journal of tropical medicine and hygiene JO - Am. J. Trop. Med. Hyg. VL - 98 IS - 3 N2 - Zika virus (ZIKV), an emerging mosquito-borne flavivirus, causes a dengue-like infection that has recently caught global attention. The infection, which also includes some birth defects, has been documented in the Americas, Pacific Islands, and some parts of Africa and Asia. There are no published reports on local ZIKV transmission in Myanmar. In this study, a total of 462 serum samples from patients and asymptomatic persons were collected in Myanmar from 2004 to 2017. They were analyzed for ZIKV infection by immunoglobulin M capture enzyme-linked immunosorbent assay (ELISA), immunoglobulin G indirect ELISA, neutralization test, real-time polymerase chain reaction (PCR), and conventional PCR. Our study confirmed ZIKV infection in 4.9% of patients with clinical dengue symptoms and in 8.6% of persons who were asymptomatic. This is the first report on ZIKV infection in Myanmar and it suggests the occurrence of ZIKV infection in two geographically distinct sites in this country since at least 2006. SN - 1476-1645 UR - https://www.unboundmedicine.com/medline/citation/29363460/full_citation L2 - http://www.ajtmh.org/content/journals/10.4269/ajtmh.17-0708?crawler=true&mimetype=application/pdf DB - PRIME DP - Unbound Medicine ER -