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Clinical features of demyelinating optic neuritis with seropositive myelin oligodendrocyte glycoprotein antibody in Chinese patients.
Br J Ophthalmol. 2018 10; 102(10):1372-1377.BJ

Abstract

BACKGROUND/AIMS

To investigate the clinical features of Chinese patients with seropositive myelin oligodendrocyte glycoprotein antibody (MOG-Ab) optic neuritis (ON) and patients with seropositive aquaporin-4 antibody (AQP4-Ab) ON.

METHODS

In this retrospective observational study, sera from patients with demyelinating ON were tested for MOG-Ab and AQP4-Ab with a cell-based assay. Clinical characteristics were compared between MOG-Ab-related ON (MOG-ON) and AQP4-Ab-related ON (AQP4-ON), including visual performances, serum autoantibodies and features on MRI.

RESULTS

A total of 109 affected eyes from 65 patients with demyelinating ON (20 MOG-ON and 45 AQP4-ON) were included. The onset age of MOG-ON was younger than AQP4-ON (MOG-ON: 20.2±17.4 years old, AQP4-ON: 35.6±15.7 years old, P=0.001). Onset severity was not different between these two groups (P=0.112), but patients with MOG-ON showed better visual outcomes (P=0.004). Half of the MOG-ON had a relapsing disease course. Nineteen per cent of patients with AQP4-ON presented coexisting autoimmune disorders, but there were no coexisting autoimmune disorders among patients with MOG-ON. Optic nerve head swelling was more prevalent in patients with MOG-ON (P<0.01). Retrobulbar segment involvement of the optic nerve were more common in patients with MOG-ON according to our MRI findings (P<0.01). Patients with MOG-ON showed longitudinally extensive lesion in 30% and chiasm and optic tract involvement in 5%.

CONCLUSIONS

MOG-ON is not rare in Chinese demyelinating patients. It underwent a severe vision loss at onset but had relatively better visual recovery than patients with AQP4-ON. MOG-ON might have an unique pathogenesis different from AQP4-ON.

Authors+Show Affiliations

Department of Ophthalmology, Chinese PLA General Hospital, Beijing, China. Department of Ophthalmology, Qingdao Municipal Hospital, Qingdao, China.Department of Ophthalmology, Chinese PLA General Hospital, Beijing, China. Joint Shantou International Eye Center, Shantou University and Chinese University of Hong Kong, Shantou, China.Department of Ophthalmology and Visual sciences, The Chinese University of Hong Kong, Kowloon, Hong Kong.Department of Ophthalmology, Chinese PLA General Hospital, Beijing, China.Department of Ophthalmology, Chinese PLA General Hospital, Beijing, China.Department of Ophthalmology, Chinese PLA General Hospital, Beijing, China.Department of Ophthalmology, Chinese PLA General Hospital, Beijing, China.Department of Ophthalmology, Chinese PLA General Hospital, Beijing, China.

Pub Type(s)

Comparative Study
Journal Article
Observational Study
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

29363529

Citation

Zhao, Ying, et al. "Clinical Features of Demyelinating Optic Neuritis With Seropositive Myelin Oligodendrocyte Glycoprotein Antibody in Chinese Patients." The British Journal of Ophthalmology, vol. 102, no. 10, 2018, pp. 1372-1377.
Zhao Y, Tan S, Chan TCY, et al. Clinical features of demyelinating optic neuritis with seropositive myelin oligodendrocyte glycoprotein antibody in Chinese patients. Br J Ophthalmol. 2018;102(10):1372-1377.
Zhao, Y., Tan, S., Chan, T. C. Y., Xu, Q., Zhao, J., Teng, D., Fu, H., & Wei, S. (2018). Clinical features of demyelinating optic neuritis with seropositive myelin oligodendrocyte glycoprotein antibody in Chinese patients. The British Journal of Ophthalmology, 102(10), 1372-1377. https://doi.org/10.1136/bjophthalmol-2017-311177
Zhao Y, et al. Clinical Features of Demyelinating Optic Neuritis With Seropositive Myelin Oligodendrocyte Glycoprotein Antibody in Chinese Patients. Br J Ophthalmol. 2018;102(10):1372-1377. PubMed PMID: 29363529.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Clinical features of demyelinating optic neuritis with seropositive myelin oligodendrocyte glycoprotein antibody in Chinese patients. AU - Zhao,Ying, AU - Tan,Shaoying, AU - Chan,Tommy Chung Yan, AU - Xu,Quangang, AU - Zhao,Jie, AU - Teng,Da, AU - Fu,Heyun, AU - Wei,Shihui, Y1 - 2018/01/23/ PY - 2017/08/08/received PY - 2017/12/06/revised PY - 2017/12/14/accepted PY - 2018/1/25/pubmed PY - 2019/3/29/medline PY - 2018/1/25/entrez KW - aquaporin-4 antibody KW - clinical features KW - magnetic resonance imaging KW - myelin oligodendrocyte glycoprotein antibody KW - optic neuritis KW - visual performances SP - 1372 EP - 1377 JF - The British journal of ophthalmology JO - Br J Ophthalmol VL - 102 IS - 10 N2 - BACKGROUND/AIMS: To investigate the clinical features of Chinese patients with seropositive myelin oligodendrocyte glycoprotein antibody (MOG-Ab) optic neuritis (ON) and patients with seropositive aquaporin-4 antibody (AQP4-Ab) ON. METHODS: In this retrospective observational study, sera from patients with demyelinating ON were tested for MOG-Ab and AQP4-Ab with a cell-based assay. Clinical characteristics were compared between MOG-Ab-related ON (MOG-ON) and AQP4-Ab-related ON (AQP4-ON), including visual performances, serum autoantibodies and features on MRI. RESULTS: A total of 109 affected eyes from 65 patients with demyelinating ON (20 MOG-ON and 45 AQP4-ON) were included. The onset age of MOG-ON was younger than AQP4-ON (MOG-ON: 20.2±17.4 years old, AQP4-ON: 35.6±15.7 years old, P=0.001). Onset severity was not different between these two groups (P=0.112), but patients with MOG-ON showed better visual outcomes (P=0.004). Half of the MOG-ON had a relapsing disease course. Nineteen per cent of patients with AQP4-ON presented coexisting autoimmune disorders, but there were no coexisting autoimmune disorders among patients with MOG-ON. Optic nerve head swelling was more prevalent in patients with MOG-ON (P<0.01). Retrobulbar segment involvement of the optic nerve were more common in patients with MOG-ON according to our MRI findings (P<0.01). Patients with MOG-ON showed longitudinally extensive lesion in 30% and chiasm and optic tract involvement in 5%. CONCLUSIONS: MOG-ON is not rare in Chinese demyelinating patients. It underwent a severe vision loss at onset but had relatively better visual recovery than patients with AQP4-ON. MOG-ON might have an unique pathogenesis different from AQP4-ON. SN - 1468-2079 UR - https://www.unboundmedicine.com/medline/citation/29363529/Clinical_features_of_demyelinating_optic_neuritis_with_seropositive_myelin_oligodendrocyte_glycoprotein_antibody_in_Chinese_patients_ L2 - http://bjo.bmj.com/cgi/pmidlookup?view=long&amp;pmid=29363529 DB - PRIME DP - Unbound Medicine ER -