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Early Relief of Pruritus in Atopic Dermatitis with Crisaborole Ointment, A Non-steroidal, Phosphodiesterase 4 Inhibitor.
Acta Derm Venereol. 2018 Apr 27; 98(5):484-489.AD

Abstract

Pruritus occurs in all patients with atopic dermatitis and requires quick relief to reduce disease exacerbation and improve quality of life. Crisaborole ointment is a non-steroidal phosphodiesterase 4 inhibitor for the treatment of mild-to-moderate atopic dermatitis. This post hoc analysis explores crisaborole ointment for early relief of pruritus in patients with mild to moderate atopic dermatitis from 2 phase III studies. Patients received crisaborole or vehicle twice daily for 28 days. Pruritus was graded on a 4-point scale of none (0) to severe (3). Early improvement in pruritus required a score of none (0) or mild (1), with a ≥ 1-grade improvement from baseline on day 6. Significantly more patients experienced early improvement in pruritus with crisaborole than with vehicle (56.6% vs 39.5%; p< 0.001), including at earliest assessment (day 2, 34.3% vs 27.3%; p = 0.013). Crisaborole is a topical treatment option that can rapidly relieve atopic dermatitis-associated pruritus.

Authors+Show Affiliations

Department of Dermatology and Cutaneous Surgery, University of Miami Miller School of Medicine, 1600 NW 10th Avenue, RMSB 2023A, 33136 Miami, FL, USA. Yosipog@gmail.com, gyosipovitch@med.miami.edu.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial, Phase III
Journal Article
Multicenter Study
Randomized Controlled Trial

Language

eng

PubMed ID

29363715

Citation

Yosipovitch, Gil, et al. "Early Relief of Pruritus in Atopic Dermatitis With Crisaborole Ointment, a Non-steroidal, Phosphodiesterase 4 Inhibitor." Acta Dermato-venereologica, vol. 98, no. 5, 2018, pp. 484-489.
Yosipovitch G, Gold LF, Lebwohl MG, et al. Early Relief of Pruritus in Atopic Dermatitis with Crisaborole Ointment, A Non-steroidal, Phosphodiesterase 4 Inhibitor. Acta Derm Venereol. 2018;98(5):484-489.
Yosipovitch, G., Gold, L. F., Lebwohl, M. G., Silverberg, J. I., Tallman, A. M., & Zane, L. T. (2018). Early Relief of Pruritus in Atopic Dermatitis with Crisaborole Ointment, A Non-steroidal, Phosphodiesterase 4 Inhibitor. Acta Dermato-venereologica, 98(5), 484-489. https://doi.org/10.2340/00015555-2893
Yosipovitch G, et al. Early Relief of Pruritus in Atopic Dermatitis With Crisaborole Ointment, a Non-steroidal, Phosphodiesterase 4 Inhibitor. Acta Derm Venereol. 2018 Apr 27;98(5):484-489. PubMed PMID: 29363715.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Early Relief of Pruritus in Atopic Dermatitis with Crisaborole Ointment, A Non-steroidal, Phosphodiesterase 4 Inhibitor. AU - Yosipovitch,Gil, AU - Gold,Linda F, AU - Lebwohl,Mark G, AU - Silverberg,Jonathan I, AU - Tallman,Anna M, AU - Zane,Lee T, PY - 2018/1/25/pubmed PY - 2018/9/25/medline PY - 2018/1/25/entrez SP - 484 EP - 489 JF - Acta dermato-venereologica JO - Acta Derm. Venereol. VL - 98 IS - 5 N2 - Pruritus occurs in all patients with atopic dermatitis and requires quick relief to reduce disease exacerbation and improve quality of life. Crisaborole ointment is a non-steroidal phosphodiesterase 4 inhibitor for the treatment of mild-to-moderate atopic dermatitis. This post hoc analysis explores crisaborole ointment for early relief of pruritus in patients with mild to moderate atopic dermatitis from 2 phase III studies. Patients received crisaborole or vehicle twice daily for 28 days. Pruritus was graded on a 4-point scale of none (0) to severe (3). Early improvement in pruritus required a score of none (0) or mild (1), with a ≥ 1-grade improvement from baseline on day 6. Significantly more patients experienced early improvement in pruritus with crisaborole than with vehicle (56.6% vs 39.5%; p< 0.001), including at earliest assessment (day 2, 34.3% vs 27.3%; p = 0.013). Crisaborole is a topical treatment option that can rapidly relieve atopic dermatitis-associated pruritus. SN - 1651-2057 UR - https://www.unboundmedicine.com/medline/citation/29363715/Early_Relief_of_Pruritus_in_Atopic_Dermatitis_with_Crisaborole_Ointment_A_Non_steroidal_Phosphodiesterase_4_Inhibitor_ DB - PRIME DP - Unbound Medicine ER -