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Associations between maternal phenol and paraben urinary biomarkers and maternal hormones during pregnancy: A repeated measures study.
Environ Int. 2018 04; 113:341-349.EI

Abstract

BACKGROUND

A number of phenols and parabens are added to consumer products for a variety of functions, and have been found at detectable levels in the majority of the U.S.

POPULATION

Among other functions, thyroid hormones are essential in fetal neurodevelopment, and could be impacted by the endocrine disrupting effects of phenols and parabens. The present study investigated the association between ten maternal urinary phenol and paraben biomarkers (bisphenol S, triclosan, triclocarban, benzophenone-3, 2,4-dichlorophenol, 2,5-dichlorophenol, and ethyl, butyl, methyl and propyl paraben) and four plasma thyroid hormones in 439 pregnant women in a case-control sample nested within a cohort study based in Boston, MA.

METHODS

Urine and blood samples were collected from up to four visits during pregnancy (median weeks of gestation at each visit: Visit 1: 9.64, Visit 2: 17.9, Visit 3: 26.0, Visit 4: 35.1). Linear mixed models were constructed to take into account the repeated measures jointly, followed by multivariate linear regression models stratified by gestational age to explore potential windows of susceptibility.

RESULTS

We observed decreased total triiodothyronine (T3) in relation to an IQR increase in benzophenone-3 (percent change [%Δ] = -2.07; 95% confidence interval [CI] = -4.16, 0.01), butyl paraben (%Δ = -2.76; 95% CI = -5.25, -0.26) and triclosan (%Δ = -2.53; 95% CI = -4.75, -0.30), and triclocarban at levels above the LOD (%Δ = -5.71; 95% CI = -10.45, -0.97). A 2.41% increase in T3 was associated with an IQR increase in methyl paraben (95% CI = 0.58, 4.24). We also detected a negative association between free thyroxine (FT4) and propyl paraben (%Δ = -3.14; 95% CI = -6.12, -0.06), and a suggestive positive association between total thyroxine (T4) and methyl paraben (%Δ = 1.19; 95% CI = -0.10, 2.47). Gestational age-specific multivariate regression analyses showed that the magnitude and direction of some of the observed associations were dependent on the timing of exposure.

CONCLUSION

Certain phenols and parabens were associated with altered thyroid hormone levels during pregnancy, and the timing of exposure influenced the association between phenol and paraben, and hormone concentrations. These changes may contribute to downstream maternal and fetal health outcomes. Additional research is required to replicate the associations, and determine the potential biological mechanisms underlying the observed associations.

Authors+Show Affiliations

Department of Environmental Health Sciences, University of Michigan School of Public Health, 1415 Washington Heights, Ann Arbor, MI 48109, USA.Department of Environmental Health Sciences, University of Michigan School of Public Health, 1415 Washington Heights, Ann Arbor, MI 48109, USA.Division of Maternal and Fetal Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.Division of Maternal and Fetal Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.Department of Biostatistics, University of Michigan School of Public Health, 1415 Washington Heights, Ann Arbor, MI 48109, USA.Department of Environmental Health Sciences, University of Michigan School of Public Health, 1415 Washington Heights, Ann Arbor, MI 48109, USA. Electronic address: meekerj@umich.edu.

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.

Language

eng

PubMed ID

29366524

Citation

Aker, Amira M., et al. "Associations Between Maternal Phenol and Paraben Urinary Biomarkers and Maternal Hormones During Pregnancy: a Repeated Measures Study." Environment International, vol. 113, 2018, pp. 341-349.
Aker AM, Johns L, McElrath TF, et al. Associations between maternal phenol and paraben urinary biomarkers and maternal hormones during pregnancy: A repeated measures study. Environ Int. 2018;113:341-349.
Aker, A. M., Johns, L., McElrath, T. F., Cantonwine, D. E., Mukherjee, B., & Meeker, J. D. (2018). Associations between maternal phenol and paraben urinary biomarkers and maternal hormones during pregnancy: A repeated measures study. Environment International, 113, 341-349. https://doi.org/10.1016/j.envint.2018.01.006
Aker AM, et al. Associations Between Maternal Phenol and Paraben Urinary Biomarkers and Maternal Hormones During Pregnancy: a Repeated Measures Study. Environ Int. 2018;113:341-349. PubMed PMID: 29366524.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Associations between maternal phenol and paraben urinary biomarkers and maternal hormones during pregnancy: A repeated measures study. AU - Aker,Amira M, AU - Johns,Lauren, AU - McElrath,Thomas F, AU - Cantonwine,David E, AU - Mukherjee,Bhramar, AU - Meeker,John D, Y1 - 2018/02/01/ PY - 2017/10/02/received PY - 2018/01/10/revised PY - 2018/01/12/accepted PY - 2018/1/26/pubmed PY - 2018/12/15/medline PY - 2018/1/26/entrez KW - In-utero KW - Parabens KW - Phenols KW - Pregnancy KW - Thyroid hormones SP - 341 EP - 349 JF - Environment international JO - Environ Int VL - 113 N2 - BACKGROUND: A number of phenols and parabens are added to consumer products for a variety of functions, and have been found at detectable levels in the majority of the U.S. POPULATION: Among other functions, thyroid hormones are essential in fetal neurodevelopment, and could be impacted by the endocrine disrupting effects of phenols and parabens. The present study investigated the association between ten maternal urinary phenol and paraben biomarkers (bisphenol S, triclosan, triclocarban, benzophenone-3, 2,4-dichlorophenol, 2,5-dichlorophenol, and ethyl, butyl, methyl and propyl paraben) and four plasma thyroid hormones in 439 pregnant women in a case-control sample nested within a cohort study based in Boston, MA. METHODS: Urine and blood samples were collected from up to four visits during pregnancy (median weeks of gestation at each visit: Visit 1: 9.64, Visit 2: 17.9, Visit 3: 26.0, Visit 4: 35.1). Linear mixed models were constructed to take into account the repeated measures jointly, followed by multivariate linear regression models stratified by gestational age to explore potential windows of susceptibility. RESULTS: We observed decreased total triiodothyronine (T3) in relation to an IQR increase in benzophenone-3 (percent change [%Δ] = -2.07; 95% confidence interval [CI] = -4.16, 0.01), butyl paraben (%Δ = -2.76; 95% CI = -5.25, -0.26) and triclosan (%Δ = -2.53; 95% CI = -4.75, -0.30), and triclocarban at levels above the LOD (%Δ = -5.71; 95% CI = -10.45, -0.97). A 2.41% increase in T3 was associated with an IQR increase in methyl paraben (95% CI = 0.58, 4.24). We also detected a negative association between free thyroxine (FT4) and propyl paraben (%Δ = -3.14; 95% CI = -6.12, -0.06), and a suggestive positive association between total thyroxine (T4) and methyl paraben (%Δ = 1.19; 95% CI = -0.10, 2.47). Gestational age-specific multivariate regression analyses showed that the magnitude and direction of some of the observed associations were dependent on the timing of exposure. CONCLUSION: Certain phenols and parabens were associated with altered thyroid hormone levels during pregnancy, and the timing of exposure influenced the association between phenol and paraben, and hormone concentrations. These changes may contribute to downstream maternal and fetal health outcomes. Additional research is required to replicate the associations, and determine the potential biological mechanisms underlying the observed associations. SN - 1873-6750 UR - https://www.unboundmedicine.com/medline/citation/29366524/Associations_between_maternal_phenol_and_paraben_urinary_biomarkers_and_maternal_hormones_during_pregnancy:_A_repeated_measures_study_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0160-4120(17)31748-8 DB - PRIME DP - Unbound Medicine ER -