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Association of chronic kidney disease with mortality risk in patients with lung cancer: a nationwide Taiwan population-based cohort study.
BMJ Open 2018; 8(1):e019661BO

Abstract

OBJECTIVE

Our population-based research aimed to clarify the association between chronic kidney disease (CKD) and mortality risk in patients with lung cancer.

DESIGN

Retrospective cohort study SETTING: National health insurance research database in Taiwan PARTICIPANTS: All (n=1 37 077) Taiwanese residents who were diagnosed with lung cancer between 1997 and 2012 were identified. Eligible patients with baseline CKD (n=2269) were matched with controls (1:4, n=9076) without renal disease according to age, sex and the index day of lung cancer diagnosis.

METHODS

The cumulative incidence of death was calculated by the Kaplan-Meier method, and the risk determinants were explored by the Cox proportional hazards model.

RESULTS

Mortality occurred in 1866 (82.24%) and 7135 (78.61%) patients with and without CKD, respectively (P=0.0001). The cumulative incidences of mortality in patients with and without chronic renal disease were 72.8% vs 61.6% at 1 year, 82.0% vs 76.6% at 2 years and 88.9% vs 87.2% at 5 years, respectively. After adjusting for multiple confounding factors including age and comorbidities, Cox regression analysis revealed that CKD was associated with an increased risk of mortality (adjusted HR 1.38; 95% CI 1.29 to 1.47). Stratified analysis further showed that the association was consistent across patient subgroups.

CONCLUSION

Comorbidity associated with CKD is a risk factor for mortality in patients with lung cancer.

Authors+Show Affiliations

Department of Internal Medicine, E-Da Hospital/I-Shou University, Kaohsiung, Taiwan. Institute of Biotechnology and Chemical Engineering, I-Shou University, Kaohsiung, Taiwan.Department of Internal Medicine, E-Da Hospital/I-Shou University, Kaohsiung, Taiwan.Department of Internal Medicine, E-Da Hospital/I-Shou University, Kaohsiung, Taiwan.Department of Internal Medicine, E-Da Hospital/I-Shou University, Kaohsiung, Taiwan.Department of Internal Medicine, E-Da Hospital/I-Shou University, Kaohsiung, Taiwan.Department of Internal Medicine, E-Da Hospital/I-Shou University, Kaohsiung, Taiwan. School of Medicine and Big Data Research Center, College of Medicine Fu-Jen Catholic University, New Taipei, Taiwan. Department of Medical Research, Fu-Jen Catholic University Hospital, New Taipei, Taiwan. Graduate Institute of Clinical Medicine, China Medical University, Taichung, Taiwan.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

29371286

Citation

Wei, Yu-Feng, et al. "Association of Chronic Kidney Disease With Mortality Risk in Patients With Lung Cancer: a Nationwide Taiwan Population-based Cohort Study." BMJ Open, vol. 8, no. 1, 2018, pp. e019661.
Wei YF, Chen JY, Lee HS, et al. Association of chronic kidney disease with mortality risk in patients with lung cancer: a nationwide Taiwan population-based cohort study. BMJ Open. 2018;8(1):e019661.
Wei, Y. F., Chen, J. Y., Lee, H. S., Wu, J. T., Hsu, C. K., & Hsu, Y. C. (2018). Association of chronic kidney disease with mortality risk in patients with lung cancer: a nationwide Taiwan population-based cohort study. BMJ Open, 8(1), pp. e019661. doi:10.1136/bmjopen-2017-019661.
Wei YF, et al. Association of Chronic Kidney Disease With Mortality Risk in Patients With Lung Cancer: a Nationwide Taiwan Population-based Cohort Study. BMJ Open. 2018 01 24;8(1):e019661. PubMed PMID: 29371286.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Association of chronic kidney disease with mortality risk in patients with lung cancer: a nationwide Taiwan population-based cohort study. AU - Wei,Yu-Feng, AU - Chen,Jung-Yueh, AU - Lee,Ho-Shen, AU - Wu,Jiun-Ting, AU - Hsu,Chi-Kuei, AU - Hsu,Yao-Chun, Y1 - 2018/01/24/ PY - 2018/1/27/entrez PY - 2018/1/27/pubmed PY - 2018/8/18/medline KW - chronic kidney disease KW - lung cancer KW - mortality SP - e019661 EP - e019661 JF - BMJ open JO - BMJ Open VL - 8 IS - 1 N2 - OBJECTIVE: Our population-based research aimed to clarify the association between chronic kidney disease (CKD) and mortality risk in patients with lung cancer. DESIGN: Retrospective cohort study SETTING: National health insurance research database in Taiwan PARTICIPANTS: All (n=1 37 077) Taiwanese residents who were diagnosed with lung cancer between 1997 and 2012 were identified. Eligible patients with baseline CKD (n=2269) were matched with controls (1:4, n=9076) without renal disease according to age, sex and the index day of lung cancer diagnosis. METHODS: The cumulative incidence of death was calculated by the Kaplan-Meier method, and the risk determinants were explored by the Cox proportional hazards model. RESULTS: Mortality occurred in 1866 (82.24%) and 7135 (78.61%) patients with and without CKD, respectively (P=0.0001). The cumulative incidences of mortality in patients with and without chronic renal disease were 72.8% vs 61.6% at 1 year, 82.0% vs 76.6% at 2 years and 88.9% vs 87.2% at 5 years, respectively. After adjusting for multiple confounding factors including age and comorbidities, Cox regression analysis revealed that CKD was associated with an increased risk of mortality (adjusted HR 1.38; 95% CI 1.29 to 1.47). Stratified analysis further showed that the association was consistent across patient subgroups. CONCLUSION: Comorbidity associated with CKD is a risk factor for mortality in patients with lung cancer. SN - 2044-6055 UR - https://www.unboundmedicine.com/medline/citation/29371286/Association_of_chronic_kidney_disease_with_mortality_risk_in_patients_with_lung_cancer:_a_nationwide_Taiwan_population_based_cohort_study_ L2 - http://bmjopen.bmj.com/cgi/pmidlookup?view=long&pmid=29371286 DB - PRIME DP - Unbound Medicine ER -